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Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.
Huang JK, Fancy SP, Zhao C, Rowitch DH, Ffrench-Constant C, Franklin RJ. Huang JK, et al. Neurotherapeutics. 2011 Oct;8(4):650-8. doi: 10.1007/s13311-011-0065-x. Neurotherapeutics. 2011. PMID: 21904791 Free PMC article. Review.
Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.
de la Fuente AG, Errea O, van Wijngaarden P, Gonzalez GA, Kerninon C, Jarjour AA, Lewis HJ, Jones CA, Nait-Oumesmar B, Zhao C, Huang JK, ffrench-Constant C, Franklin RJ. de la Fuente AG, et al. J Cell Biol. 2015 Dec 7;211(5):975-85. doi: 10.1083/jcb.201505119. J Cell Biol. 2015. PMID: 26644513 Free PMC article.
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
Moyon S, Dubessy AL, Aigrot MS, Trotter M, Huang JK, Dauphinot L, Potier MC, Kerninon C, Melik Parsadaniantz S, Franklin RJ, Lubetzki C. Moyon S, et al. J Neurosci. 2015 Jan 7;35(1):4-20. doi: 10.1523/JNEUROSCI.0849-14.2015. J Neurosci. 2015. PMID: 25568099 Free PMC article.
Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination.
Syed YA, Baer A, Hofer MP, González GA, Rundle J, Myrta S, Huang JK, Zhao C, Rossner MJ, Trotter MW, Lubec G, Franklin RJ, Kotter MR. Syed YA, et al. EMBO Mol Med. 2013 Dec;5(12):1918-34. doi: 10.1002/emmm.201303123. Epub 2013 Oct 21. EMBO Mol Med. 2013. PMID: 24293318 Free PMC article.
Retinoid X receptor gamma signaling accelerates CNS remyelination.
Huang JK, Jarjour AA, Nait Oumesmar B, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Baron-Van Evercooren A, Chambon P, Ffrench-Constant C, Franklin RJM. Huang JK, et al. Nat Neurosci. 2011 Jan;14(1):45-53. doi: 10.1038/nn.2702. Epub 2010 Dec 5. Nat Neurosci. 2011. PMID: 21131950 Free PMC article.
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