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TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells.
Chen YW, Lee MS, Lucht A, Chou FP, Huang W, Havighurst TC, Kim K, Wang JK, Antalis TM, Johnson MD, Lin CY. Chen YW, et al. Among authors: huang w. Am J Pathol. 2010 Jun;176(6):2986-96. doi: 10.2353/ajpath.2010.090665. Epub 2010 Apr 9. Am J Pathol. 2010. PMID: 20382709 Free PMC article.
PTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer.
Conley-LaComb MK, Huang W, Wang S, Shi D, Jung YS, Najy A, Fridman R, Bonfil RD, Cher ML, Chen YQ, Kim HC. Conley-LaComb MK, et al. Among authors: huang w. Am J Pathol. 2012 Mar;180(3):1017-1027. doi: 10.1016/j.ajpath.2011.11.021. Epub 2011 Dec 28. Am J Pathol. 2012. PMID: 22209699 Free PMC article.
Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy.
Gee JR, Saltzstein DR, Messing E, Kim K, Kolesar J, Huang W, Havighurst TC, Harris L, Wollmer BW, Jarrard D, House M, Parnes H, Bailey HH. Gee JR, et al. Among authors: huang w. Eur J Cancer Prev. 2016 Jul;25(4):312-20. doi: 10.1097/CEJ.0000000000000189. Eur J Cancer Prev. 2016. PMID: 26313229 Clinical Trial.
A phase II randomized placebo-controlled trial of pomegranate fruit extract in men with localized prostate cancer undergoing active surveillance.
Jarrard D, Filon M, Huang W, Havighurst T, DeShong K, Kim K, Konety BR, Saltzstein D, Mukhtar H, Wollmer B, Suen C, House MG, Parnes HL, Bailey HH. Jarrard D, et al. Among authors: huang w. Prostate. 2021 Jan;81(1):41-49. doi: 10.1002/pros.24076. Epub 2020 Oct 23. Prostate. 2021. PMID: 33095939 Clinical Trial.
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