Huang XP - Search Results

1

Automated design of ligands to polypharmacological profiles.

Besnard J, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang XP, Norval S, Sassano MF, Shin AI, Webster LA, Simeons FR, Stojanovski L, Prat A, Seidah NG, Constam DB, Bickerton GR, Read KD, Wetsel WC, Gilbert IH, Roth BL, Hopkins AL. Besnard J, et al. Among authors: huang xp. Nature. 2012 Dec 13;492(7428):215-20. doi: 10.1038/nature11691. Nature. 2012. PMID: 23235874 Free PMC article.

2

Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.

Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A. Tang H, et al. Among authors: huang xp. J Chem Inf Model. 2009 Feb;49(2):461-76. doi: 10.1021/ci800366f. J Chem Inf Model. 2009. PMID: 19182860

3

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo.

Abbas AI, Hedlund PB, Huang XP, Tran TB, Meltzer HY, Roth BL. Abbas AI, et al. Among authors: huang xp. Psychopharmacology (Berl). 2009 Jul;205(1):119-28. doi: 10.1007/s00213-009-1521-8. Epub 2009 Apr 1. Psychopharmacology (Berl). 2009. PMID: 19337725 Free PMC article.

4

Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.

Huang XP, Setola V, Yadav PN, Allen JA, Rogan SC, Hanson BJ, Revankar C, Robers M, Doucette C, Roth BL. Huang XP, et al. Mol Pharmacol. 2009 Oct;76(4):710-22. doi: 10.1124/mol.109.058057. Epub 2009 Jul 1. Mol Pharmacol. 2009. PMID: 19570945 Free PMC article.

5

N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.

Kwon YJ, Saubern S, Macdonald JM, Huang XP, Setola V, Roth BL. Kwon YJ, et al. Among authors: huang xp. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5488-90. doi: 10.1016/j.bmcl.2010.07.074. Epub 2010 Jul 21. Bioorg Med Chem Lett. 2010. PMID: 20692833

6

Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.

Hajjo R, Grulke CM, Golbraikh A, Setola V, Huang XP, Roth BL, Tropsha A. Hajjo R, et al. Among authors: huang xp. J Med Chem. 2010 Nov 11;53(21):7573-86. doi: 10.1021/jm100600y. J Med Chem. 2010. PMID: 20958049 Free PMC article.

7

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

Huang XP, Mangano T, Hufeisen S, Setola V, Roth BL. Huang XP, et al. Assay Drug Dev Technol. 2010 Dec;8(6):727-42. doi: 10.1089/adt.2010.0331. Assay Drug Dev Technol. 2010. PMID: 21158687 Free PMC article.

8

Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.

Allen JA, Yost JM, Setola V, Chen X, Sassano MF, Chen M, Peterson S, Yadav PN, Huang XP, Feng B, Jensen NH, Che X, Bai X, Frye SV, Wetsel WC, Caron MG, Javitch JA, Roth BL, Jin J. Allen JA, et al. Among authors: huang xp. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93. doi: 10.1073/pnas.1104807108. Epub 2011 Oct 24. Proc Natl Acad Sci U S A. 2011. PMID: 22025698 Free PMC article.

9

Structure of the human κ-opioid receptor in complex with JDTic.

Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC. Wu H, et al. Among authors: huang xp. Nature. 2012 Mar 21;485(7398):327-32. doi: 10.1038/nature10939. Nature. 2012. PMID: 22437504 Free PMC article.

10

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.

Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC. Thompson AA, et al. Among authors: huang xp. Nature. 2012 May 16;485(7398):395-9. doi: 10.1038/nature11085. Nature. 2012. PMID: 22596163 Free PMC article.

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