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A single-nucleotide polymorphism in CYP2B6 leads to >3-fold increases in efavirenz concentrations in plasma and hair among HIV-infected women.
Gandhi M, Greenblatt RM, Bacchetti P, Jin C, Huang Y, Anastos K, Cohen M, Dehovitz JA, Sharp GB, Gange SJ, Liu C, Hanson SC, Aouizerat B; Women's Interagency HIV Study. Gandhi M, et al. Among authors: huang y. J Infect Dis. 2012 Nov;206(9):1453-61. doi: 10.1093/infdis/jis508. Epub 2012 Aug 20. J Infect Dis. 2012. PMID: 22927450 Free PMC article.
Protease inhibitor levels in hair strongly predict virologic response to treatment.
Gandhi M, Ameli N, Bacchetti P, Gange SJ, Anastos K, Levine A, Hyman CL, Cohen M, Young M, Huang Y, Greenblatt RM; Women's Interagency HIV Study (WIHS). Gandhi M, et al. Among authors: huang y. AIDS. 2009 Feb 20;23(4):471-8. doi: 10.1097/QAD.0b013e328325a4a9. AIDS. 2009. PMID: 19165084 Free PMC article.
Strong relationship between oral dose and tenofovir hair levels in a randomized trial: hair as a potential adherence measure for pre-exposure prophylaxis (PrEP).
Liu AY, Yang Q, Huang Y, Bacchetti P, Anderson PL, Jin C, Goggin K, Stojanovski K, Grant R, Buchbinder SP, Greenblatt RM, Gandhi M. Liu AY, et al. Among authors: huang y. PLoS One. 2014 Jan 8;9(1):e83736. doi: 10.1371/journal.pone.0083736. eCollection 2014. PLoS One. 2014. PMID: 24421901 Free PMC article. Clinical Trial.
Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV-Infected Women.
Tamraz B, Huang Y, French AL, Kassaye S, Anastos K, Nowicki MJ, Gange S, Gustafson DR, Bacchetti P, Greenblatt RM, Hysi PG, Aouizerat BE; Women's Interagency HIV Study. Tamraz B, et al. Among authors: huang y. Clin Pharmacol Ther. 2020 Feb;107(2):315-318. doi: 10.1002/cpt.1605. Epub 2019 Sep 28. Clin Pharmacol Ther. 2020. PMID: 31562781 Free PMC article.
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