Huang Z - Search Results

1

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.

Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. Suh JM, et al. Among authors: huang z. Nature. 2014 Sep 18;513(7518):436-9. doi: 10.1038/nature13540. Epub 2014 Jul 16. Nature. 2014. PMID: 25043058 Free PMC article.

2

Cracking the molecular origin of intrinsic tyrosine kinase activity through analysis of pathogenic gain-of-function mutations.

Chen H, Huang Z, Dutta K, Blais S, Neubert TA, Li X, Cowburn D, Traaseth NJ, Mohammadi M. Chen H, et al. Among authors: huang z. Cell Rep. 2013 Jul 25;4(2):376-84. doi: 10.1016/j.celrep.2013.06.025. Epub 2013 Jul 18. Cell Rep. 2013. PMID: 23871672 Free PMC article.

3

Structural mimicry of a-loop tyrosine phosphorylation by a pathogenic FGF receptor 3 mutation.

Huang Z, Chen H, Blais S, Neubert TA, Li X, Mohammadi M. Huang Z, et al. Structure. 2013 Oct 8;21(10):1889-96. doi: 10.1016/j.str.2013.07.017. Epub 2013 Aug 22. Structure. 2013. PMID: 23972473 Free PMC article.

4

DFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors.

Huang Z, Tan L, Wang H, Liu Y, Blais S, Deng J, Neubert TA, Gray NS, Li X, Mohammadi M. Huang Z, et al. ACS Chem Biol. 2015 Jan 16;10(1):299-309. doi: 10.1021/cb500674s. Epub 2014 Oct 27. ACS Chem Biol. 2015. PMID: 25317566 Free PMC article.

5

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.

Tan L, Wang J, Tanizaki J, Huang Z, Aref AR, Rusan M, Zhu SJ, Zhang Y, Ercan D, Liao RG, Capelletti M, Zhou W, Hur W, Kim N, Sim T, Gaudet S, Barbie DA, Yeh JR, Yun CH, Hammerman PS, Mohammadi M, Jänne PA, Gray NS. Tan L, et al. Among authors: huang z. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77. doi: 10.1073/pnas.1403438111. Epub 2014 Oct 27. Proc Natl Acad Sci U S A. 2014. PMID: 25349422 Free PMC article.

6

Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.

Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. Suh JM, et al. Among authors: huang z. Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14304. Epub 2015 Mar 4. Nature. 2015. PMID: 25739500 No abstract available.

7

Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ.

Huang Z, Marsiglia WM, Basu Roy U, Rahimi N, Ilghari D, Wang H, Chen H, Gai W, Blais S, Neubert TA, Mansukhani A, Traaseth NJ, Li X, Mohammadi M. Huang Z, et al. Mol Cell. 2016 Jan 7;61(1):98-110. doi: 10.1016/j.molcel.2015.11.010. Epub 2015 Dec 10. Mol Cell. 2016. PMID: 26687682 Free PMC article.

8

Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.

Chen H, Marsiglia WM, Cho MK, Huang Z, Deng J, Blais SP, Gai W, Bhattacharya S, Neubert TA, Traaseth NJ, Mohammadi M. Chen H, et al. Among authors: huang z. Elife. 2017 Feb 6;6:e21137. doi: 10.7554/eLife.21137. Elife. 2017. PMID: 28166054 Free PMC article.

9

Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism.

Liang G, Song L, Chen Z, Qian Y, Xie J, Zhao L, Lin Q, Zhu G, Tan Y, Li X, Mohammadi M, Huang Z. Liang G, et al. Among authors: huang z. Kidney Int. 2018 Jan;93(1):95-109. doi: 10.1016/j.kint.2017.05.013. Epub 2017 Jul 24. Kidney Int. 2018. PMID: 28750927 Free PMC article.

10

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability.

Huang Z, Tan Y, Gu J, Liu Y, Song L, Niu J, Zhao L, Srinivasan L, Lin Q, Deng J, Li Y, Conklin DJ, Neubert TA, Cai L, Li X, Mohammadi M. Huang Z, et al. Cell Rep. 2017 Aug 15;20(7):1717-1728. doi: 10.1016/j.celrep.2017.06.063. Cell Rep. 2017. PMID: 28813681 Free PMC article.

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