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2021 3
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Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy.
Deng Y, Qiao L, Du M, Qu C, Wan L, Li J, Huang L. Deng Y, et al. Genes Dis. 2021 Feb 27;9(1):62-79. doi: 10.1016/j.gendis.2021.02.009. eCollection 2022 Jan. Genes Dis. 2021. PMID: 35005108 Free PMC article. Review.
Multiple genetic factors, lipid metabolism, oxidative stress and aging, play a role in the etiology of AMD. Dysregulation in genetic to AMD is established to 46%-71% of disease contribution, with CFH and ARMS2/HTRA1 to be the two most notable risk loci among the 103 identi …
Multiple genetic factors, lipid metabolism, oxidative stress and aging, play a role in the etiology of AMD. Dysregulation in genetic …
Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction.
Yu H, Liao K, Hu Y, Lv D, Luo M, Liu Q, Huang L, Luo S. Yu H, et al. Aging Dis. 2022 Dec 1;13(6):1901-1918. doi: 10.14336/AD.2022.0316. eCollection 2022 Dec 1. Aging Dis. 2022. PMID: 36465181 Free PMC article.
A decline in endothelial function, up-regulation of p53, p21 and p16 expression, and activation of the cGAS-STING pathway were observed in aging mice. Inhibition of cGAS was found to improve endothelial function and reverse the increased expression of aging markers. …
A decline in endothelial function, up-regulation of p53, p21 and p16 expression, and activation of the cGAS-STING pathway were observed in …
Aquaporin-4 and Cognitive Disorders.
Wang Y, Huang C, Guo Q, Chu H. Wang Y, et al. Aging Dis. 2022 Feb 1;13(1):61-72. doi: 10.14336/AD.2021.0731. eCollection 2022 Feb. Aging Dis. 2022. PMID: 35111362 Free PMC article. Review.
DNA Methylation Modulates Aging Process in Adipocytes.
Xie H, Liu X, Zhou Q, Huang T, Zhang L, Gao J, Wang Y, Liu Y, Yan T, Zhang S, Wang CY. Xie H, et al. Aging Dis. 2022 Apr 1;13(2):433-446. doi: 10.14336/AD.2021.0904. eCollection 2022 Apr. Aging Dis. 2022. PMID: 35371604 Free PMC article. Review.
The well-established association between DNA methylation (DNAm) and aging has been observed in the past few decades. Indeed, age-related alteration in DNAm is highly tissue-specific. ...Elucidation of the effect of DNAm on adipose aging would have great potential to …
The well-established association between DNA methylation (DNAm) and aging has been observed in the past few decades. Indeed, age-rela …
Role of Calcium Homeostasis in Alzheimer's Disease.
Ge M, Zhang J, Chen S, Huang Y, Chen W, He L, Zhang Y. Ge M, et al. Neuropsychiatr Dis Treat. 2022 Mar 3;18:487-498. doi: 10.2147/NDT.S350939. eCollection 2022. Neuropsychiatr Dis Treat. 2022. PMID: 35264851 Free PMC article. Review.
Alzheimer's disease (AD) is a neurodegenerative disease associated with senile plaques (SP) and neurofibrillary tangles (NFTs) in the brain. With aging of the population, AD has become the most common form of dementia. However, the mechanisms leading to AD are still under …
Alzheimer's disease (AD) is a neurodegenerative disease associated with senile plaques (SP) and neurofibrillary tangles (NFTs) in the brain. …
Neuronal Intranuclear Inclusion Disease with NOTCH2NLC GGC Repeat Expansion: A Systematic Review and Challenges of Phenotypic Characterization.
Zeng T, Chen Y, Huang H, Li S, Huang J, Xie H, Lin S, Chen S, Chen G, Yang D. Zeng T, et al. Aging Dis. 2024 Feb 16;16(1):578-97. doi: 10.14336/AD.2024.0131-1. Online ahead of print. Aging Dis. 2024. PMID: 38377026 Free PMC article.
A literature search was conducted in PubMed, Embase, and the Cochrane Library from September 1, 2019, to December 31, 2022, encompassing reported NIID cases confirmed by pathogenic NOTCH2NLC mutations. Linear regressions and trend analyses were performed. ...
A literature search was conducted in PubMed, Embase, and the Cochrane Library from September 1, 2019, to December 31, 2022, encompass …
China Initiative for Multi-Domain Intervention (CHINA-IN-MUDI) to Prevent Cognitive Decline: Study Design and Progress.
Li SY, Xie XY, Liu D, Cheng GR, Hu FF, Zeng DY, Chen XC, Jia LF, Wang YJ, Bu XL, Qiu C, Gao F, Gu JG, Liu MF, Li Y, Zhou YL, Chang HJ, Ou YM, Xu L, Wu ZX, Zhang JJ, Wang JY, Huang LY, Cui YY, Zhou J, Liu XC, Liu J, Nie QQ, Song D, Cai C, Han GB, Yang X, Tan W, Yu JT, Zeng Y. Li SY, et al. J Prev Alzheimers Dis. 2024;11(3):589-600. doi: 10.14283/jpad.2024.63. J Prev Alzheimers Dis. 2024. PMID: 38706275 Clinical Trial.
Participants aged 60-80 years were recruited from a nationally representative study, i.e. China Healthy Aging and Dementia Study cohort. An external harmonization process was carried out to preserve the original FINGER design. ...To enhance adherence and facilitate impleme …
Participants aged 60-80 years were recruited from a nationally representative study, i.e. China Healthy Aging and Dementia Study coho …
42 results