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Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis.
Liang J, Huang Y, Mai Z, Zhan Q, Lin H, Xie Y, Wang H, Liu Y, Luo C. Liang J, et al. Drug Des Devel Ther. 2021 Apr 30;15:1779-1795. doi: 10.2147/DDDT.S304911. eCollection 2021. Drug Des Devel Ther. 2021. PMID: 33958856 Free PMC article.
BACKGROUND: This study used network pharmacology, molecular docking and experimental validation to assess the effects of Huanglian Jiedu Decoction (HLJDD) on atherosclerosis (AS). METHODS: The components and targets of HLJDD were analyzed using the Traditiona …
BACKGROUND: This study used network pharmacology, molecular docking and experimental validation to assess the effects of Huanglian …
Neuraminidase 1 and its Inhibitors from Chinese Herbal Medicines: An Emerging Role for Cardiovascular Diseases.
Zhang JY, Chen QQ, Li J, Zhang L, Qi LW. Zhang JY, et al. Am J Chin Med. 2021;49(4):843-862. doi: 10.1142/S0192415X21500403. Epub 2021 Apr 6. Am J Chin Med. 2021. PMID: 33827385 Review.
Recent studies have revealed the involvement of Neu1 in several diseases, including cardiovascular diseases, diabetes, cancers, and neurological disorders. ...Many Chinese herbs and Chinese herb preparations, such as Lonicerae Japonicae Flos, Scutellariae Radix, Yupingfeng …
Recent studies have revealed the involvement of Neu1 in several diseases, including cardiovascular diseases, diabetes, cancers, and n …
Study on the Mechanism of Huanglian Jiedu Decoction in Treating Dyslipidemia Based on Network Pharmacology.
Gong Z, Li R, Chen S, Wu H, Cai Y, Li J, Zhao X, Chu Q, Luo C, Qing L, Li N, Wu W. Gong Z, et al. J Healthc Eng. 2022 Aug 24;2022:2457706. doi: 10.1155/2022/2457706. eCollection 2022. J Healthc Eng. 2022. PMID: 36061816 Free PMC article.
OBJECTIVE: This study aimed to determine the active ingredients of Huanglian Jiedu decoction (HLJDD) and the targets for treating dyslipidemia through network pharmacology to facilitate further application of HJJDD in the treatment of dyslipidemia. ...
OBJECTIVE: This study aimed to determine the active ingredients of Huanglian Jiedu decoction (HLJDD) and the targets fo …
Effect of huanglian jiedu decoction on thoracic aorta gene expression in spontaneous hypertensive rats.
Yue GH, Zhuo SY, Xia M, Zhang Z, Gao YW, Luo Y. Yue GH, et al. Evid Based Complement Alternat Med. 2014;2014:565784. doi: 10.1155/2014/565784. Epub 2014 Mar 13. Evid Based Complement Alternat Med. 2014. PMID: 24744811 Free PMC article.
Objective. Hypertension is one of the most common cardiovascular disorders with high mortality. Here we explored the antihypertension effects of Huanglian Jiedu Decoction (HJD) on thoracic aorta gene expression in spontaneous hypertensive rats. ...GC d …
Objective. Hypertension is one of the most common cardiovascular disorders with high mortality. Here we explored the antihypertension …
The effective components of Huanglian Jiedu Decoction against sepsis evaluated by a lipid A-based affinity biosensor.
Chen GR, Zhang G, Li MY, Jing J, Wang J, Zhang X, Mackie B, Dou DQ. Chen GR, et al. J Ethnopharmacol. 2016 Jun 20;186:369-376. doi: 10.1016/j.jep.2016.03.064. Epub 2016 Apr 1. J Ethnopharmacol. 2016. PMID: 27045865
ETHNOPHARMACOLOGICAL RELEVANCE: Huanglian Jiedu Decoction (HJD), the classical recipe for relieving fever and toxicity, has been used for treating sepsis in China for sixteen years. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Huanglian Jiedu Decoction (HJD), the classical recipe for relieving fever and toxicity, …
[Common anti-inflammatory effects of heat-clearing and toxin-removing Chinese medicines on diverse cardiovascular diseases].
Wang D, Yu X, Huang K, Tang JY, Wei XQ, Pu HY, Guo SZ. Wang D, et al. Zhongguo Zhong Yao Za Zhi. 2022 Oct;47(20):5418-5423. doi: 10.19540/j.cnki.cjcmm.20220601.701. Zhongguo Zhong Yao Za Zhi. 2022. PMID: 36471955 Chinese.
There is also new understanding of the pathogenesis and treatment of cardiovascular diseases in TCM. The heat-toxicity theory in cardiovascular diseases and the therapeutic principle of clearing heat and removing toxin have attracted attention. The clinical and phar …
There is also new understanding of the pathogenesis and treatment of cardiovascular diseases in TCM. The heat-toxicity theory in c …
[Explore new clinical application of Huanglian and corresponding compound prescriptions from their traditional use].
Feng YB, Luo WQ, Zhu SQ. Feng YB, et al. Zhongguo Zhong Yao Za Zhi. 2008 May;33(10):1221-5. Zhongguo Zhong Yao Za Zhi. 2008. PMID: 18720877 Chinese.
Huanglian is a commonly used Chinese medicinal herb in the ancient and the present. It has a history of 2000 years in clinical application, having the efficacy of "Clear away heat and remove dampness, purge the sthenic fire and eliminate toxic materials", therefore can be …
Huanglian is a commonly used Chinese medicinal herb in the ancient and the present. It has a history of 2000 years in clinical applic …
Effects of traditional Chinese formulations on rat carotid artery injured by balloon endothelial denudation.
Chung HJ, Kim DW, Maruyama I, Tani T. Chung HJ, et al. Am J Chin Med. 2003;31(2):201-12. doi: 10.1142/S0192415X03000941. Am J Chin Med. 2003. PMID: 12856859
We examined the inhibitory effects of traditional Chinese formulations (TCFs: Kampo formulation in Japanese) on intimal thickening of the carotid artery injured by balloon endothelial denudation in rats. Among the eight TCFs examined oren-gedoku-to (huanglian-jiedu- …
We examined the inhibitory effects of traditional Chinese formulations (TCFs: Kampo formulation in Japanese) on intimal thickening of the ca …
[Protective effects of Huanglian Jiedu decoction on vascular endothelial function in type 2 diabetic rats].
Xiao YL, Lu FE, Xu LJ, Leng SH, Wang KF. Xiao YL, et al. Zhongguo Zhong Yao Za Zhi. 2005 Nov;30(22):1767-70. Zhongguo Zhong Yao Za Zhi. 2005. PMID: 16468376 Chinese.
OBJECTIVE: To investigate the effects of Huanglian Jiedu (HLJD) decoction on vascular endothelial function in type 2 diabetic rats and explore the prophylactic and therapeutic significance and pharmacological mechanism of HLJD decoction in type 2 diabe …
OBJECTIVE: To investigate the effects of Huanglian Jiedu (HLJD) decoction on vascular endothelial function in type 2 di …
[Effect of effective components of huanglian jiedu decoction on hypoxia, reoxygenation injury and the expression of VCAM in cultured rat cerebral microvascular endothelial cells].
Yuan ZZ, Zhu LQ, Pang H, Shan ZS, Wang SR, Gao YH, Niu FL. Yuan ZZ, et al. Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(23):2813-7. Zhongguo Zhong Yao Za Zhi. 2008. PMID: 19260319 Chinese.
CONCLUSION: The results suggest that geniposide, baicalin and berberine, which are effective compositions of huanglian jiedu decoting, can protect hypoxia-reoxygenation injuried rat cerebral microvascular endothelial cells. ...
CONCLUSION: The results suggest that geniposide, baicalin and berberine, which are effective compositions of huanglian jiedu d …
12 results