Hubbard BP - Search Results

1

Lifespan and healthspan extension by resveratrol.

Bhullar KS, Hubbard BP. Bhullar KS, et al. Among authors: hubbard bp. Biochim Biophys Acta. 2015 Jun;1852(6):1209-18. doi: 10.1016/j.bbadis.2015.01.012. Epub 2015 Jan 29. Biochim Biophys Acta. 2015. PMID: 25640851 Review.

2

Synthesis and Assay of SIRT1-Activating Compounds.

Dai H, Ellis JL, Sinclair DA, Hubbard BP. Dai H, et al. Among authors: hubbard bp. Methods Enzymol. 2016;574:213-244. doi: 10.1016/bs.mie.2016.01.012. Epub 2016 Feb 9. Methods Enzymol. 2016. PMID: 27423864 Free PMC article.

3

Small molecule SIRT1 activators for the treatment of aging and age-related diseases.

Hubbard BP, Sinclair DA. Hubbard BP, et al. Trends Pharmacol Sci. 2014 Mar;35(3):146-54. doi: 10.1016/j.tips.2013.12.004. Epub 2014 Jan 16. Trends Pharmacol Sci. 2014. PMID: 24439680 Free PMC article. Review.

4

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction.

Rascón B, Hubbard BP, Sinclair DA, Amdam GV. Rascón B, et al. Among authors: hubbard bp. Aging (Albany NY). 2012 Jul;4(7):499-508. doi: 10.18632/aging.100474. Aging (Albany NY). 2012. PMID: 22868943 Free PMC article.

5

SRT1720 improves survival and healthspan of obese mice.

Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. Minor RK, et al. Among authors: hubbard bp. Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Sci Rep. 2011. PMID: 22355589 Free PMC article.

6

Kinase-targeted cancer therapies: progress, challenges and future directions.

Bhullar KS, Lagarón NO, McGowan EM, Parmar I, Jha A, Hubbard BP, Rupasinghe HPV. Bhullar KS, et al. Among authors: hubbard bp. Mol Cancer. 2018 Feb 19;17(1):48. doi: 10.1186/s12943-018-0804-2. Mol Cancer. 2018. PMID: 29455673 Free PMC article. Review.

7

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.

Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP. Gomes AP, et al. Among authors: hubbard bp. Biochim Biophys Acta. 2012 Feb;1822(2):185-95. doi: 10.1016/j.bbadis.2011.10.008. Epub 2011 Oct 17. Biochim Biophys Acta. 2012. PMID: 22027215 Free PMC article.

8

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL. Dai H, et al. Among authors: hubbard bp. J Biol Chem. 2010 Oct 22;285(43):32695-703. doi: 10.1074/jbc.M110.133892. Epub 2010 Aug 11. J Biol Chem. 2010. PMID: 20702418 Free PMC article.

9

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism.

Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA. Hubbard BP, et al. Cell Cycle. 2013 Jul 15;12(14):2233-40. doi: 10.4161/cc.25268. Cell Cycle. 2013. PMID: 23892437 Free PMC article.

10

Evidence for a common mechanism of SIRT1 regulation by allosteric activators.

Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Hubbard BP, et al. Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097. Science. 2013. PMID: 23471411 Free PMC article.

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