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Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease.
Chen J, Farraj RA, Limonta D, Tabatabaei Dakhili SA, Kerek EM, Bhattacharya A, Reformat FM, Mabrouk OM, Brigant B, Pfeifer TA, McDermott MT, Ussher JR, Hobman TC, Glover JNM, Hubbard BP. Chen J, et al. Among authors: hubbard bp. J Biol Chem. 2023 Nov;299(11):105341. doi: 10.1016/j.jbc.2023.105341. Epub 2023 Oct 11. J Biol Chem. 2023. PMID: 37832873 Free PMC article.
Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition.
Beauchamp E, Gamma JM, Cromwell CR, Moussa EW, Pain R, Kostiuk MA, Acevedo-Morantes C, Iyer A, Yap M, Vincent KM, Postovit LM, Julien O, Hubbard BP, Mackey JR, Berthiaume LG. Beauchamp E, et al. Among authors: hubbard bp. J Transl Med. 2024 May 7;22(1):431. doi: 10.1186/s12967-024-05150-6. J Transl Med. 2024. PMID: 38715059 Free PMC article.
Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket.
Schmidt EN, Lamprinaki D, McCord KA, Joe M, Sojitra M, Waldow A, Nguyen J, Monyror J, Kitova EN, Mozaneh F, Guo XY, Jung J, Enterina JR, Daskhan GC, Han L, Krysler AR, Cromwell CR, Hubbard BP, West LJ, Kulka M, Sipione S, Klassen JS, Derda R, Lowary TL, Mahal LK, Riddell MR, Macauley MS. Schmidt EN, et al. Among authors: hubbard bp. Nat Commun. 2023 Apr 22;14(1):2327. doi: 10.1038/s41467-023-38030-6. Nat Commun. 2023. PMID: 37087495 Free PMC article.
CRISPR-Click Enables Dual-Gene Editing with Modular Synthetic sgRNAs.
Park H, Osman EA, Cromwell CR, St Laurent CD, Liu Y, Kitova EN, Klassen JS, Hubbard BP, Macauley MS, Gibbs JM. Park H, et al. Among authors: hubbard bp. Bioconjug Chem. 2022 May 18;33(5):858-868. doi: 10.1021/acs.bioconjchem.2c00106. Epub 2022 Apr 18. Bioconjug Chem. 2022. PMID: 35436106
A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer.
Boukouris AE, Zhang Y, Saleme B, Kinnaird A, Zhao YY, Liu Y, Zervopoulos SD, Das SK, Mittal RD, Haromy A, Lorenzana-Carrillo MA, Krysler AR, Cromwell CR, Hubbard BP, Sutendra G, Michelakis ED. Boukouris AE, et al. Among authors: hubbard bp. Cell Rep. 2022 Mar 15;38(11):110511. doi: 10.1016/j.celrep.2022.110511. Cell Rep. 2022. PMID: 35294884 Free article.
40 results