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Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.
Favelyukis S, Till JH, Hubbard SR, Miller WT. Favelyukis S, et al. Among authors: hubbard sr. Nat Struct Biol. 2001 Dec;8(12):1058-63. doi: 10.1038/nsb721. Nat Struct Biol. 2001. PMID: 11694888
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.
Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O. Ungureanu D, et al. Among authors: hubbard sr. Nat Struct Mol Biol. 2011 Aug 14;18(9):971-6. doi: 10.1038/nsmb.2099. Nat Struct Mol Biol. 2011. PMID: 21841788 Free PMC article.
The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.
Cabail MZ, Li S, Lemmon E, Bowen ME, Hubbard SR, Miller WT. Cabail MZ, et al. Among authors: hubbard sr. Nat Commun. 2015 Mar 11;6:6406. doi: 10.1038/ncomms7406. Nat Commun. 2015. PMID: 25758790 Free PMC article.
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Bandaranayake RM, Ungureanu D, Shan Y, Shaw DE, Silvennoinen O, Hubbard SR. Bandaranayake RM, et al. Among authors: hubbard sr. Nat Struct Mol Biol. 2012 Aug;19(8):754-9. doi: 10.1038/nsmb.2348. Epub 2012 Jul 22. Nat Struct Mol Biol. 2012. PMID: 22820988 Free PMC article.
Structural biology: Insulin meets its receptor.
Hubbard SR. Hubbard SR. Nature. 2013 Jan 10;493(7431):171-2. doi: 10.1038/493171a. Nature. 2013. PMID: 23302856 No abstract available.
The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.
Hubbard SR. Hubbard SR. Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a008946. doi: 10.1101/cshperspect.a008946. Cold Spring Harb Perspect Biol. 2013. PMID: 23457259 Free PMC article. Review.
Closing in on a mechanism for activation.
Hubbard SR, Miller WT. Hubbard SR, et al. Elife. 2014 Oct 28;3:e04909. doi: 10.7554/eLife.04909. Elife. 2014. PMID: 25350976 Free PMC article.
Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design.
Hines AC, Parang K, Kohanski RA, Hubbard SR, Cole PA. Hines AC, et al. Among authors: hubbard sr. Bioorg Chem. 2005 Aug;33(4):285-97. doi: 10.1016/j.bioorg.2005.02.002. Epub 2005 Apr 19. Bioorg Chem. 2005. PMID: 16023488
Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase.
Li S, Depetris RS, Barford D, Chernoff J, Hubbard SR. Li S, et al. Among authors: hubbard sr. Structure. 2005 Nov;13(11):1643-51. doi: 10.1016/j.str.2005.07.019. Structure. 2005. PMID: 16271887
Crystal structure of the human laminin receptor precursor.
Jamieson KV, Wu J, Hubbard SR, Meruelo D. Jamieson KV, et al. Among authors: hubbard sr. J Biol Chem. 2008 Feb 8;283(6):3002-5. doi: 10.1074/jbc.C700206200. Epub 2007 Dec 6. J Biol Chem. 2008. PMID: 18063583
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