Hubbard SR - Search Results

1

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.

Hubbard SR. Hubbard SR. EMBO J. 1997 Sep 15;16(18):5572-81. doi: 10.1093/emboj/16.18.5572. EMBO J. 1997. PMID: 9312016 Free PMC article.

2

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.

Cabail MZ, Li S, Lemmon E, Bowen ME, Hubbard SR, Miller WT. Cabail MZ, et al. Among authors: hubbard sr. Nat Commun. 2015 Mar 11;6:6406. doi: 10.1038/ncomms7406. Nat Commun. 2015. PMID: 25758790 Free PMC article.

3

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.

Hammarén HM, Ungureanu D, Grisouard J, Skoda RC, Hubbard SR, Silvennoinen O. Hammarén HM, et al. Among authors: hubbard sr. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4642-7. doi: 10.1073/pnas.1423201112. Epub 2015 Mar 30. Proc Natl Acad Sci U S A. 2015. PMID: 25825724 Free PMC article.

4

Structural basis for the interaction of the adaptor protein grb14 with activated ras.

Qamra R, Hubbard SR. Qamra R, et al. Among authors: hubbard sr. PLoS One. 2013 Aug 13;8(8):e72473. doi: 10.1371/journal.pone.0072473. eCollection 2013. PLoS One. 2013. PMID: 23967305 Free PMC article.

5

Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation.

Hubbard SR, Gnanasambandan K. Hubbard SR, et al. Biochim Biophys Acta. 2013 Oct;1834(10):2166-9. doi: 10.1016/j.bbapap.2013.02.034. Epub 2013 Mar 5. Biochim Biophys Acta. 2013. PMID: 23467009 Free PMC article. Review.

6

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.

Bandaranayake RM, Ungureanu D, Shan Y, Shaw DE, Silvennoinen O, Hubbard SR. Bandaranayake RM, et al. Among authors: hubbard sr. Nat Struct Mol Biol. 2012 Aug;19(8):754-9. doi: 10.1038/nsmb.2348. Epub 2012 Jul 22. Nat Struct Mol Biol. 2012. PMID: 22820988 Free PMC article.

7

Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1.

Ji T, Corbalán-García S, Hubbard SR. Ji T, et al. Among authors: hubbard sr. PLoS One. 2018 Jun 28;13(6):e0199942. doi: 10.1371/journal.pone.0199942. eCollection 2018. PLoS One. 2018. PMID: 29953543 Free PMC article.

8

Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase.

Hubbard SR. Hubbard SR. Front Endocrinol (Lausanne). 2018 Jan 5;8:361. doi: 10.3389/fendo.2017.00361. eCollection 2017. Front Endocrinol (Lausanne). 2018. PMID: 29379470 Free PMC article. Review.

9

The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.

Hubbard SR. Hubbard SR. Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a008946. doi: 10.1101/cshperspect.a008946. Cold Spring Harb Perspect Biol. 2013. PMID: 23457259 Free PMC article. Review.

10

Closing in on a mechanism for activation.

Hubbard SR, Miller WT. Hubbard SR, et al. Elife. 2014 Oct 28;3:e04909. doi: 10.7554/eLife.04909. Elife. 2014. PMID: 25350976 Free PMC article.

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