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Engineering disulfide-linked single-chain Fv dimers [(sFv')2] with improved solution and targeting properties: anti-digoxin 26-10 (sFv')2 and anti-c-erbB-2 741F8 (sFv')2 made by protein folding and bonded through C-terminal cysteinyl peptides.
McCartney JE, Tai MS, Hudziak RM, Adams GP, Weiner LM, Jin D, Stafford WF 3rd, Liu S, Bookman MA, Laminet AA, et al. McCartney JE, et al. Among authors: hudziak rm. Protein Eng. 1995 Mar;8(3):301-14. doi: 10.1093/protein/8.3.301. Protein Eng. 1995. PMID: 7479692
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