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Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Marco-Contelles J, León R, de los Ríos C, Samadi A, Bartolini M, Andrisano V, Huertas O, Barril X, Luque FJ, Rodríguez-Franco MI, López B, López MG, García AG, Carreiras Mdo C, Villarroya M. Marco-Contelles J, et al. Among authors: huertas o. J Med Chem. 2009 May 14;52(9):2724-32. doi: 10.1021/jm801292b. J Med Chem. 2009. PMID: 19374444
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Camps P, Formosa X, Galdeano C, Muñoz-Torrero D, Ramírez L, Gómez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodríguez-Franco MI, Huertas O, Dafni T, Luque FJ. Camps P, et al. Among authors: huertas o. J Med Chem. 2009 Sep 10;52(17):5365-79. doi: 10.1021/jm900859q. J Med Chem. 2009. PMID: 19663388
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.
Camps P, Formosa X, Galdeano C, Gómez T, Muñoz-Torrero D, Ramírez L, Viayna E, Gómez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Bidon-Chanal A, Huertas O, Dafni T, Luque FJ. Camps P, et al. Among authors: huertas o. Chem Biol Interact. 2010 Sep 6;187(1-3):411-5. doi: 10.1016/j.cbi.2010.02.013. Epub 2010 Feb 16. Chem Biol Interact. 2010. PMID: 20167211
Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors.
Castaño T, Wang H, Campillo NE, Ballester S, González-García C, Hernández J, Pérez C, Cuenca J, Pérez-Castillo A, Martínez A, Huertas O, Gelpí JL, Luque FJ, Ke H, Gil C. Castaño T, et al. Among authors: huertas o. ChemMedChem. 2009 May;4(5):866-76. doi: 10.1002/cmdc.200900043. ChemMedChem. 2009. PMID: 19350606 Free PMC article.
Ab initio study of naphtho-homologated DNA bases.
Vazquez-Mayagoita A, Huertas O, Fuentes-Cabrera M, Sumpter BG, Orozco M, Luque FJ. Vazquez-Mayagoita A, et al. Among authors: huertas o. J Phys Chem B. 2008 Feb 21;112(7):2179-86. doi: 10.1021/jp7095746. Epub 2008 Jan 29. J Phys Chem B. 2008. PMID: 18225888
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