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Genome-scale reconstruction of the Streptococcus pyogenes M49 metabolic network reveals growth requirements and indicates potential drug targets.
Levering J, Fiedler T, Sieg A, van Grinsven KW, Hering S, Veith N, Olivier BG, Klett L, Hugenholtz J, Teusink B, Kreikemeyer B, Kummer U. Levering J, et al. Among authors: hugenholtz j. J Biotechnol. 2016 Aug 20;232:25-37. doi: 10.1016/j.jbiotec.2016.01.035. Epub 2016 Mar 10. J Biotechnol. 2016. PMID: 26970054
Using a genome-scale metabolic model of Enterococcus faecalis V583 to assess amino acid uptake and its impact on central metabolism.
Veith N, Solheim M, van Grinsven KW, Olivier BG, Levering J, Grosseholz R, Hugenholtz J, Holo H, Nes I, Teusink B, Kummer U. Veith N, et al. Among authors: hugenholtz j. Appl Environ Microbiol. 2015 Mar;81(5):1622-33. doi: 10.1128/AEM.03279-14. Epub 2014 Dec 19. Appl Environ Microbiol. 2015. PMID: 25527553 Free PMC article.
Characterization of three lactic acid bacteria and their isogenic ldh deletion mutants shows optimization for YATP (cell mass produced per mole of ATP) at their physiological pHs.
Fiedler T, Bekker M, Jonsson M, Mehmeti I, Pritzschke A, Siemens N, Nes I, Hugenholtz J, Kreikemeyer B. Fiedler T, et al. Among authors: hugenholtz j. Appl Environ Microbiol. 2011 Jan;77(2):612-7. doi: 10.1128/AEM.01838-10. Epub 2010 Nov 19. Appl Environ Microbiol. 2011. PMID: 21097579 Free PMC article.
Understanding the physiology of Lactobacillus plantarum at zero growth.
Goffin P, van de Bunt B, Giovane M, Leveau JH, Höppener-Ogawa S, Teusink B, Hugenholtz J. Goffin P, et al. Among authors: hugenholtz j. Mol Syst Biol. 2010 Sep 21;6:413. doi: 10.1038/msb.2010.67. Mol Syst Biol. 2010. PMID: 20865006 Free PMC article.
107 results