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An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee.
Huggins JP, Smart TS, Langman S, Taylor L, Young T. Huggins JP, et al. Pain. 2012 Sep;153(9):1837-1846. doi: 10.1016/j.pain.2012.04.020. Epub 2012 Jun 21. Pain. 2012. PMID: 22727500 Clinical Trial.
Pharmacologic modulation of hand pain in osteoarthritis: a double-blind placebo-controlled functional magnetic resonance imaging study using naproxen.
Sanders D, Krause K, O'Muircheartaigh J, Thacker MA, Huggins JP, Vennart W, Massat NJ, Choy E, Williams SC, Howard MA. Sanders D, et al. Among authors: huggins jp. Arthritis Rheumatol. 2015 Mar;67(3):741-51. doi: 10.1002/art.38987. Arthritis Rheumatol. 2015. PMID: 25533872 Free PMC article. Clinical Trial.
Effects of gabapentin on experimental somatic pain and temporal summation.
Arendt-Nielsen L, Frøkjaer JB, Staahl C, Graven-Nielsen T, Huggins JP, Smart TS, Drewes AM. Arendt-Nielsen L, et al. Among authors: huggins jp. Reg Anesth Pain Med. 2007 Sep-Oct;32(5):382-8. doi: 10.1016/j.rapm.2007.05.002. Reg Anesth Pain Med. 2007. PMID: 17961835 Clinical Trial.
Alterations in resting-state regional cerebral blood flow demonstrate ongoing pain in osteoarthritis: An arterial spin-labeled magnetic resonance imaging study.
Howard MA, Sanders D, Krause K, O'Muircheartaigh J, Fotopoulou A, Zelaya F, Thacker M, Massat N, Huggins JP, Vennart W, Choy E, Daniels M, Williams SC. Howard MA, et al. Among authors: huggins jp. Arthritis Rheum. 2012 Dec;64(12):3936-46. doi: 10.1002/art.37685. Arthritis Rheum. 2012. PMID: 22933378 Free article.
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