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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 5
1947 10
1948 5
1949 3
1950 3
1951 2
1952 4
1953 2
1954 4
1955 4
1956 6
1957 5
1958 2
1959 5
1960 7
1961 2
1962 5
1963 5
1964 4
1965 10
1966 12
1967 3
1968 7
1969 11
1970 12
1971 7
1972 11
1973 12
1974 7
1975 11
1976 14
1977 7
1978 5
1979 9
1980 10
1981 12
1982 7
1983 15
1984 26
1985 29
1986 22
1987 27
1988 23
1989 27
1990 33
1991 35
1992 40
1993 34
1994 39
1995 37
1996 33
1997 24
1998 21
1999 22
2000 26
2001 19
2002 13
2003 19
2004 24
2005 19
2006 16
2007 22
2008 22
2009 32
2010 24
2011 21
2012 18
2013 19
2014 15
2015 20
2016 28
2017 33
2018 22
2019 24
2020 21
Text availability
Article attribute
Article type
Publication date

Search Results

1,143 results
Results by year
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Page 1
A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition.
Traxler EA, Yao Y, Wang YD, Woodard KJ, Kurita R, Nakamura Y, Hughes JR, Hardison RC, Blobel GA, Li C, Weiss MJ. Traxler EA, et al. Among authors: Hughes JR. Nat Med. 2016 Sep;22(9):987-90. doi: 10.1038/nm.4170. Epub 2016 Aug 15. Nat Med. 2016. PMID: 27525524 Free PMC article.
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR. Mettananda S, et al. Among authors: Hughes JR. Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7. Nat Commun. 2017. PMID: 28871148 Free PMC article.
Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.
Hanssen LLP, Kassouf MT, Oudelaar AM, Biggs D, Preece C, Downes DJ, Gosden M, Sharpe JA, Sloane-Stanley JA, Hughes JR, Davies B, Higgs DR. Hanssen LLP, et al. Among authors: Hughes JR. Nat Cell Biol. 2017 Aug;19(8):952-961. doi: 10.1038/ncb3573. Epub 2017 Jul 24. Nat Cell Biol. 2017. PMID: 28737770 Free PMC article.
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
Yao X, Tan J, Lim KJ, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu JZ, Tay ST, Wijaya G, Lam YN, Hong JH, Lee-Lim AP, Guan P, Ng MSW, He CZ, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davies JOJ, Goh JY, Loh G, Tan BC, Rozen SG, Yu Q, Tan IBH, Cheng CWS, Li S, Chang KTE, Tan PH, Silver DL, Lezhava A, Steger G, Hughes JR, Teh BT, Tan P. Yao X, et al. Among authors: Hughes JR. Cancer Discov. 2017 Nov;7(11):1284-1305. doi: 10.1158/2159-8290.CD-17-0375. Epub 2017 Sep 11. Cancer Discov. 2017. PMID: 28893800 Free article.
Corrigendum.
Fagerström K, Hughes JR. Fagerström K, et al. Among authors: Hughes JR. Addiction. 2016 Jul;111(7):1311. doi: 10.1111/add.13434. Addiction. 2016. PMID: 27273388 No abstract available.
Multiplexed analysis of chromosome conformation at vastly improved sensitivity.
Davies JO, Telenius JM, McGowan SJ, Roberts NA, Taylor S, Higgs DR, Hughes JR. Davies JO, et al. Among authors: Hughes JR. Nat Methods. 2016 Jan;13(1):74-80. doi: 10.1038/nmeth.3664. Epub 2015 Nov 23. Nat Methods. 2016. PMID: 26595209 Free PMC article.
Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity.
Ooi WF, Xing M, Xu C, Yao X, Ramlee MK, Lim MC, Cao F, Lim K, Babu D, Poon LF, Lin Suling J, Qamra A, Irwanto A, Qu Zhengzhong J, Nandi T, Lee-Lim AP, Chan YS, Tay ST, Lee MH, Davies JO, Wong WK, Soo KC, Chan WH, Ong HS, Chow P, Wong CY, Rha SY, Liu J, Hillmer AM, Hughes JR, Rozen S, Teh BT, Fullwood MJ, Li S, Tan P. Ooi WF, et al. Among authors: Hughes JR. Nat Commun. 2016 Sep 28;7:12983. doi: 10.1038/ncomms12983. Nat Commun. 2016. PMID: 27677335 Free PMC article.
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.
Oudelaar AM, Davies JOJ, Hanssen LLP, Telenius JM, Schwessinger R, Liu Y, Brown JM, Downes DJ, Chiariello AM, Bianco S, Nicodemi M, Buckle VJ, Dekker J, Higgs DR, Hughes JR. Oudelaar AM, et al. Among authors: Hughes JR. Nat Genet. 2018 Dec;50(12):1744-1751. doi: 10.1038/s41588-018-0253-2. Epub 2018 Oct 29. Nat Genet. 2018. PMID: 30374068 Free PMC article.
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H. Pasricha SR, et al. Among authors: Hughes JR. Nat Commun. 2017 Sep 1;8(1):403. doi: 10.1038/s41467-017-00500-z. Nat Commun. 2017. PMID: 28864822 Free PMC article.
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