Hughes SH - Search Results

1

Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs.

Smith SJ, Zhao XZ, Passos DO, Lyumkis D, Burke TR Jr, Hughes SH. Smith SJ, et al. Among authors: hughes sh. Viruses. 2021 Jan 29;13(2):205. doi: 10.3390/v13020205. Viruses. 2021. PMID: 33572956 Free PMC article. Review.

2

Nontemplated base addition by HIV-1 RT can induce nonspecific strand transfer in vitro.

Golinelli MP, Hughes SH. Golinelli MP, et al. Among authors: hughes sh. Virology. 2002 Mar 1;294(1):122-34. doi: 10.1006/viro.2001.1322. Virology. 2002. PMID: 11886271 Free article.

3

2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors.

Zhao XZ, Semenova EA, Vu BC, Maddali K, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: hughes sh. J Med Chem. 2008 Jan 24;51(2):251-9. doi: 10.1021/jm070715d. Epub 2007 Dec 21. J Med Chem. 2008. PMID: 18095643

4

Mutations in the human immunodeficiency virus type 1 polypurine tract (PPT) reduce the rate of PPT cleavage and plus-strand DNA synthesis.

McWilliams MJ, Julias JG, Hughes SH. McWilliams MJ, et al. Among authors: hughes sh. J Virol. 2008 May;82(10):5104-8. doi: 10.1128/JVI.01897-07. Epub 2008 Mar 5. J Virol. 2008. PMID: 18321979 Free PMC article.

5

Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.

Zhao XZ, Maddali K, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: hughes sh. Bioorg Med Chem Lett. 2009 May 15;19(10):2714-7. doi: 10.1016/j.bmcl.2009.03.122. Epub 2009 Mar 28. Bioorg Med Chem Lett. 2009. PMID: 19364649 Free PMC article.

6

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.

Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A, Hughes SH. Ferris AL, et al. Among authors: hughes cm, hughes sh. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3135-40. doi: 10.1073/pnas.0914142107. Epub 2010 Feb 1. Proc Natl Acad Sci U S A. 2010. PMID: 20133638 Free PMC article.

7

Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: hughes sh. Bioorg Med Chem Lett. 2011 May 15;21(10):2986-90. doi: 10.1016/j.bmcl.2011.03.047. Epub 2011 Mar 21. Bioorg Med Chem Lett. 2011. PMID: 21493066 Free PMC article.

8

Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572).

Hare S, Smith SJ, Métifiot M, Jaxa-Chamiec A, Pommier Y, Hughes SH, Cherepanov P. Hare S, et al. Among authors: hughes sh. Mol Pharmacol. 2011 Oct;80(4):565-72. doi: 10.1124/mol.111.073189. Epub 2011 Jun 30. Mol Pharmacol. 2011. PMID: 21719464 Free PMC article.

9

MK-0536 inhibits HIV-1 integrases resistant to raltegravir.

Métifiot M, Johnson B, Smith S, Zhao XZ, Marchand C, Burke T, Hughes S, Pommier Y. Métifiot M, et al. Antimicrob Agents Chemother. 2011 Nov;55(11):5127-33. doi: 10.1128/AAC.05288-11. Epub 2011 Aug 29. Antimicrob Agents Chemother. 2011. PMID: 21876054 Free PMC article.

10

Molecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity.

Johnson BC, Métifiot M, Pommier Y, Hughes SH. Johnson BC, et al. Among authors: hughes sh. Antimicrob Agents Chemother. 2012 Jan;56(1):411-9. doi: 10.1128/AAC.05292-11. Epub 2011 Oct 28. Antimicrob Agents Chemother. 2012. PMID: 22037850 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

385 results

Search Page