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Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.
Parsons AB, Lopez A, Givoni IE, Williams DE, Gray CA, Porter J, Chua G, Sopko R, Brost RL, Ho CH, Wang J, Ketela T, Brenner C, Brill JA, Fernandez GE, Lorenz TC, Payne GS, Ishihara S, Ohya Y, Andrews B, Hughes TR, Frey BJ, Graham TR, Andersen RJ, Boone C. Parsons AB, et al. Among authors: hughes tr. Cell. 2006 Aug 11;126(3):611-25. doi: 10.1016/j.cell.2006.06.040. Cell. 2006. PMID: 16901791 Free article.
Mapping pathways and phenotypes by systematic gene overexpression.
Sopko R, Huang D, Preston N, Chua G, Papp B, Kafadar K, Snyder M, Oliver SG, Cyert M, Hughes TR, Boone C, Andrews B. Sopko R, et al. Among authors: hughes tr. Mol Cell. 2006 Feb 3;21(3):319-30. doi: 10.1016/j.molcel.2005.12.011. Mol Cell. 2006. PMID: 16455487 Free article.
Exploration of essential gene functions via titratable promoter alleles.
Mnaimneh S, Davierwala AP, Haynes J, Moffat J, Peng WT, Zhang W, Yang X, Pootoolal J, Chua G, Lopez A, Trochesset M, Morse D, Krogan NJ, Hiley SL, Li Z, Morris Q, Grigull J, Mitsakakis N, Roberts CJ, Greenblatt JF, Boone C, Kaiser CA, Andrews BJ, Hughes TR. Mnaimneh S, et al. Among authors: hughes tr. Cell. 2004 Jul 9;118(1):31-44. doi: 10.1016/j.cell.2004.06.013. Cell. 2004. PMID: 15242642 Free article.
The synthetic genetic interaction spectrum of essential genes.
Davierwala AP, Haynes J, Li Z, Brost RL, Robinson MD, Yu L, Mnaimneh S, Ding H, Zhu H, Chen Y, Cheng X, Brown GW, Boone C, Andrews BJ, Hughes TR. Davierwala AP, et al. Among authors: hughes tr. Nat Genet. 2005 Oct;37(10):1147-52. doi: 10.1038/ng1640. Epub 2005 Sep 11. Nat Genet. 2005. PMID: 16155567 Free article.
Identifying transcription factor functions and targets by phenotypic activation.
Chua G, Morris QD, Sopko R, Robinson MD, Ryan O, Chan ET, Frey BJ, Andrews BJ, Boone C, Hughes TR. Chua G, et al. Among authors: hughes tr. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12045-50. doi: 10.1073/pnas.0605140103. Epub 2006 Jul 31. Proc Natl Acad Sci U S A. 2006. PMID: 16880382 Free PMC article.
274 results