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DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T. Fuks F, et al. Nat Genet. 2000 Jan;24(1):88-91. doi: 10.1038/71750. Nat Genet. 2000. PMID: 10615135
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.
Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T. Hughes-Davies L, et al. Cell. 2003 Nov 26;115(5):523-35. doi: 10.1016/s0092-8674(03)00930-9. Cell. 2003. PMID: 14651845
The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase.
Milner J, Fuks F, Hughes-Davies L, Kouzarides T. Milner J, et al. Oncogene. 2000 Sep 7;19(38):4441-5. doi: 10.1038/sj.onc.1203793. Oncogene. 2000. PMID: 10980621
Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.
Ekblad CM, Chavali GB, Basu BP, Freund SM, Veprintsev D, Hughes-Davies L, Kouzarides T, Doherty AJ, Itzhaki LS. Ekblad CM, et al. EMBO Rep. 2005 Jul;6(7):675-80. doi: 10.1038/sj.embor.7400415. EMBO Rep. 2005. PMID: 15947784 Free PMC article.
Crystal structure of the ENT domain of human EMSY.
Chavali GB, Ekblad CM, Basu BP, Brissett NC, Veprintsev D, Hughes-Davies L, Kouzarides T, Itzhaki LS, Doherty AJ. Chavali GB, et al. J Mol Biol. 2005 Jul 29;350(5):964-73. doi: 10.1016/j.jmb.2005.05.047. J Mol Biol. 2005. PMID: 15978617
Transcriptional activation functions in BRCA2.
Milner J, Ponder B, Hughes-Davies L, Seltmann M, Kouzarides T. Milner J, et al. Nature. 1997 Apr 24;386(6627):772-3. doi: 10.1038/386772a0. Nature. 1997. PMID: 9126734 No abstract available.
Amplification of the BRCA2 pathway gene EMSY in sporadic breast cancer is related to negative outcome.
Rodriguez C, Hughes-Davies L, Vallès H, Orsetti B, Cuny M, Ursule L, Kouzarides T, Theillet C. Rodriguez C, et al. Clin Cancer Res. 2004 Sep 1;10(17):5785-91. doi: 10.1158/1078-0432.CCR-03-0410. Clin Cancer Res. 2004. PMID: 15355907
Comparing Breast Cancer Multiparameter Tests in the OPTIMA Prelim Trial: No Test Is More Equal Than the Others.
Bartlett JM, Bayani J, Marshall A, Dunn JA, Campbell A, Cunningham C, Sobol MS, Hall PS, Poole CJ, Cameron DA, Earl HM, Rea DW, Macpherson IR, Canney P, Francis A, McCabe C, Pinder SE, Hughes-Davies L, Makris A, Stein RC; OPTIMA TMG. Bartlett JM, et al. J Natl Cancer Inst. 2016 Apr 29;108(9):djw050. doi: 10.1093/jnci/djw050. Print 2016 Sep. J Natl Cancer Inst. 2016. PMID: 27130929 Free PMC article. Clinical Trial.
Discrepancies in central review re-testing of patients with ER-positive and HER2-negative breast cancer in the OPTIMA prelim randomised clinical trial.
Pinder SE, Campbell AF, Bartlett JM, Marshall A, Allen D, Falzon M, Dunn JA, Makris A, Hughes-Davies L, Stein RC. Pinder SE, et al. Br J Cancer. 2017 Mar 28;116(7):859-863. doi: 10.1038/bjc.2017.28. Epub 2017 Feb 21. Br J Cancer. 2017. PMID: 28222072 Free PMC article. Clinical Trial.
Inhibiting mutations in the transforming growth factor beta type 2 receptor in recurrent human breast cancer.
Lücke CD, Philpott A, Metcalfe JC, Thompson AM, Hughes-Davies L, Kemp PR, Hesketh R. Lücke CD, et al. Cancer Res. 2001 Jan 15;61(2):482-5. Cancer Res. 2001. PMID: 11212236
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