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Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.
Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M. Johnson SC, et al. Front Genet. 2015 Jul 22;6:247. doi: 10.3389/fgene.2015.00247. eCollection 2015. Front Genet. 2015. PMID: 26257774 Free PMC article.
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.
Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M. Johnson SC, et al. Science. 2013 Dec 20;342(6165):1524-8. doi: 10.1126/science.1244360. Epub 2013 Nov 14. Science. 2013. PMID: 24231806 Free PMC article.
Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.
Bielas J, Herbst A, Widjaja K, Hui J, Aiken JM, McKenzie D, Miller RA, Brooks SV, Wanagat J. Bielas J, et al. Exp Gerontol. 2018 Jun;106:125-131. doi: 10.1016/j.exger.2018.02.021. Epub 2018 Feb 24. Exp Gerontol. 2018. PMID: 29486228 Free PMC article.
Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae.
Delaney JR, Murakami C, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Wende HV, Wang AM, Wasko BM, Olsen B, Kaeberlein M. Delaney JR, et al. Exp Gerontol. 2013 Oct;48(10):1006-13. doi: 10.1016/j.exger.2012.12.001. Epub 2012 Dec 9. Exp Gerontol. 2013. PMID: 23235143 Free PMC article.
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, Olsen B, Beyer RP, Bammler TK, Prunkard D, Johnson SC, Pennypacker JK, An E, Anies A, Castanza AS, Choi E, Dang N, Enerio S, Fletcher M, Fox L, Goswami S, Higgins SA, Holmberg MA, Hu D, Hui J, Jelic M, Jeong KS, Johnston E, Kerr EO, Kim J, Kim D, Kirkland K, Klum S, Kotireddy S, Liao E, Lim M, Lin MS, Lo WC, Lockshon D, Miller HA, Moller RM, Muller B, Oakes J, Pak DN, Peng ZJ, Pham KM, Pollard TG, Pradeep P, Pruett D, Rai D, Robison B, Rodriguez AA, Ros B, Sage M, Singh MK, Smith ED, Snead K, Solanky A, Spector BL, Steffen KK, Tchao BN, Ting MK, Vander Wende H, Wang D, Welton KL, Westman EA, Brem RB, Liu XG, Suh Y, Zhou Z, Kaeberlein M, Kennedy BK. McCormick MA, et al. Cell Metab. 2015 Nov 3;22(5):895-906. doi: 10.1016/j.cmet.2015.09.008. Epub 2015 Oct 8. Cell Metab. 2015. PMID: 26456335 Free PMC article.
pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast.
Murakami C, Delaney JR, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Vander Wende H, Wang AM, Wasko BM, Olsen B, Kaeberlein M. Murakami C, et al. Cell Cycle. 2012 Aug 15;11(16):3087-96. doi: 10.4161/cc.21465. Epub 2012 Aug 8. Cell Cycle. 2012. PMID: 22871733 Free PMC article.
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