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Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope.
West BR, Moyer CL, King LB, Fusco ML, Milligan JC, Hui S, Saphire EO. West BR, et al. Among authors: Hui S. mBio. 2018 Sep 11;9(5):e01674-18. doi: 10.1128/mBio.01674-18. mBio. 2018. PMID: 30206174 Free PMC article.
The structures delineate the key protein and glycan contacts for binding that are conserved across the ebolaviruses, explain the antibody's unique broad specificity and neutralization activity, and reveal the likely mechanism behind a known escape mutation in the fusion loop region of GP2. ...The fold of Bundibugyo virus glycoprotein, not previously visualized, is similar to the fold of Ebola virus GP, and ADI-15878 binds to each virus's GP with a similar strategy and angle of attack. ...
The structures delineate the key protein and glycan contacts for binding that are conserved across the ebolaviruses, explain the antibody' …
Structural basis of broad ebolavirus neutralization by a human survivor antibody.
West BR, Wec AZ, Moyer CL, Fusco ML, Ilinykh PA, Huang K, Wirchnianski AS, James RM, Herbert AS, Hui S, Goodwin E, Howell KA, Kailasan S, Aman MJ, Walker LM, Dye JM, Bukreyev A, Chandran K, Saphire EO. West BR, et al. Among authors: Hui S. Nat Struct Mol Biol. 2019 Mar;26(3):204-212. doi: 10.1038/s41594-019-0191-4. Epub 2019 Mar 4. Nat Struct Mol Biol. 2019. PMID: 30833785 Free PMC article.
Both endosomal proteolysis of EBOV GP and binding of mAb FVM09 displace this loop, thereby increasing exposure of ADI-15946's conserved epitope and enhancing neutralization. ...
Both endosomal proteolysis of EBOV GP and binding of mAb FVM09 displace this loop, thereby increasing exposure of ADI-15946's conserv …
Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE Jr. Gilchuk P, et al. Among authors: Hui S. Immunity. 2020 Feb 18;52(2):388-403.e12. doi: 10.1016/j.immuni.2020.01.001. Epub 2020 Feb 4. Immunity. 2020. PMID: 32023489
Metabolomics reveals the "Invisible" detoxification mechanisms of Amaranthus hypochondriacus at three ages upon exposure to different levels of cadmium.
Mengdi X, Haibo D, Jiaxin L, Zhe X, Yi C, Xuan L, Haiyan M, Hui S, Tianqi A, Yunzhen L, Wenqing C. Mengdi X, et al. Among authors: Hui S. Ecotoxicol Environ Saf. 2020 Mar 23;195:110520. doi: 10.1016/j.ecoenv.2020.110520. Online ahead of print. Ecotoxicol Environ Saf. 2020. PMID: 32213366
Corrigendum to "Identification of lead-produced lipid hydroperoxides in human HepG2 cells and protection using rosmarinic and ascorbic acids with a reference to their regulatory roles on Nrf2-Keap1 antioxidant pathway" [Chem. Biol. Interact. 314 (2019) 108847].
Li Y, Darwish WS, Chen Z, Tan H, Wu Y, Suzuki H, Chiba H, Hui SP. Li Y, et al. Among authors: Hui SP. Chem Biol Interact. 2020 Mar 20:109043. doi: 10.1016/j.cbi.2020.109043. Online ahead of print. Chem Biol Interact. 2020. PMID: 32200976 No abstract available.
Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation.
Kujawski M, Sherman M, Hui S, Zuro D, Lee WH, Yazaki P, Sherman A, Szpikowska B, Chea J, Lasiewski D, Poku K, Li H, Colcher D, Wong J, Shively JE. Kujawski M, et al. Among authors: Hui S. Oncoimmunology. 2020 Feb 14;9(1):1724052. doi: 10.1080/2162402X.2020.1724052. eCollection 2020. Oncoimmunology. 2020. PMID: 32117587 Free PMC article.
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