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HPV E6, E6AP and cervical cancer.
Beaudenon S, Huibregtse JM. Beaudenon S, et al. Among authors: huibregtse jm. BMC Biochem. 2008 Oct 21;9 Suppl 1(Suppl 1):S4. doi: 10.1186/1471-2091-9-S1-S4. BMC Biochem. 2008. PMID: 19007434 Free PMC article. Review.
Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6.
Matsumoto Y, Nakagawa S, Yano T, Takizawa S, Nagasaka K, Nakagawa K, Minaguchi T, Wada O, Ooishi H, Matsumoto K, Yasugi T, Kanda T, Huibregtse JM, Taketani Y. Matsumoto Y, et al. Among authors: huibregtse jm. J Med Virol. 2006 Apr;78(4):501-7. doi: 10.1002/jmv.20568. J Med Virol. 2006. PMID: 16482544
The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase.
Kelley ML, Keiger KE, Lee CJ, Huibregtse JM. Kelley ML, et al. Among authors: huibregtse jm. J Virol. 2005 Mar;79(6):3737-47. doi: 10.1128/JVI.79.6.3737-3747.2005. J Virol. 2005. PMID: 15731267 Free PMC article.
Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.
Gao Q, Kumar A, Singh L, Huibregtse JM, Beaudenon S, Srinivasan S, Wazer DE, Band H, Band V. Gao Q, et al. Among authors: huibregtse jm. Cancer Res. 2002 Jun 1;62(11):3315-21. Cancer Res. 2002. PMID: 12036950
The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15.
Durfee LA, Lyon N, Seo K, Huibregtse JM. Durfee LA, et al. Among authors: huibregtse jm. Mol Cell. 2010 Jun 11;38(5):722-32. doi: 10.1016/j.molcel.2010.05.002. Mol Cell. 2010. PMID: 20542004 Free PMC article.
UPS shipping and handling.
Huibregtse JM. Huibregtse JM. Cell. 2005 Jan 14;120(1):2-4. doi: 10.1016/j.cell.2004.12.029. Cell. 2005. PMID: 15652473 Review.
A cotranslational ubiquitination pathway for quality control of misfolded proteins.
Wang F, Durfee LA, Huibregtse JM. Wang F, et al. Among authors: huibregtse jm. Mol Cell. 2013 May 9;50(3):368-78. doi: 10.1016/j.molcel.2013.03.009. Epub 2013 Apr 11. Mol Cell. 2013. PMID: 23583076 Free PMC article.
The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein.
Liu X, Yuan H, Fu B, Disbrow GL, Apolinario T, Tomaic V, Kelley ML, Baker CC, Huibregtse J, Schlegel R. Liu X, et al. Among authors: huibregtse j. J Biol Chem. 2005 Mar 18;280(11):10807-16. doi: 10.1074/jbc.M410343200. Epub 2005 Jan 17. J Biol Chem. 2005. PMID: 15655249
Oncoproteins encoded by the cancer-associated human papillomaviruses target the products of the retinoblastoma and p53 tumor suppressor genes.
Howley PM, Scheffner M, Huibregtse J, M√ľnger K. Howley PM, et al. Among authors: huibregtse j. Cold Spring Harb Symp Quant Biol. 1991;56:149-55. doi: 10.1101/sqb.1991.056.01.019. Cold Spring Harb Symp Quant Biol. 1991. PMID: 1668080 No abstract available.
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