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HPV E6, E6AP and cervical cancer.
Beaudenon S, Huibregtse JM. Beaudenon S, et al. Among authors: huibregtse jm. BMC Biochem. 2008 Oct 21;9 Suppl 1(Suppl 1):S4. doi: 10.1186/1471-2091-9-S1-S4. BMC Biochem. 2008. PMID: 19007434 Free PMC article. Review.
Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6.
Matsumoto Y, Nakagawa S, Yano T, Takizawa S, Nagasaka K, Nakagawa K, Minaguchi T, Wada O, Ooishi H, Matsumoto K, Yasugi T, Kanda T, Huibregtse JM, Taketani Y. Matsumoto Y, et al. Among authors: huibregtse jm. J Med Virol. 2006 Apr;78(4):501-7. doi: 10.1002/jmv.20568. J Med Virol. 2006. PMID: 16482544
Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli.
Takizawa S, Nagasaka K, Nakagawa S, Yano T, Nakagawa K, Yasugi T, Takeuchi T, Kanda T, Huibregtse JM, Akiyama T, Taketani Y. Takizawa S, et al. Among authors: huibregtse jm. Genes Cells. 2006 Apr;11(4):453-64. doi: 10.1111/j.1365-2443.2006.00954.x. Genes Cells. 2006. PMID: 16611247
Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies.
Ren J, Kee Y, Huibregtse JM, Piper RC. Ren J, et al. Among authors: huibregtse jm. Mol Biol Cell. 2007 Jan;18(1):324-35. doi: 10.1091/mbc.e06-06-0557. Epub 2006 Nov 1. Mol Biol Cell. 2007. PMID: 17079730 Free PMC article.
Regulation of catalytic activities of HECT ubiquitin ligases.
Kee Y, Huibregtse JM. Kee Y, et al. Among authors: huibregtse jm. Biochem Biophys Res Commun. 2007 Mar 9;354(2):329-33. doi: 10.1016/j.bbrc.2007.01.025. Epub 2007 Jan 16. Biochem Biophys Res Commun. 2007. PMID: 17240353 Free PMC article. Review.
Expression and assay of HECT domain ligases.
Beaudenon S, Dastur A, Huibregtse JM. Beaudenon S, et al. Among authors: huibregtse jm. Methods Enzymol. 2005;398:112-25. doi: 10.1016/S0076-6879(05)98011-7. Methods Enzymol. 2005. PMID: 16275324
High-level expression and purification of recombinant E1 enzyme.
Beaudenon S, Huibregtse JM. Beaudenon S, et al. Among authors: huibregtse jm. Methods Enzymol. 2005;398:3-8. doi: 10.1016/S0076-6879(05)98001-4. Methods Enzymol. 2005. PMID: 16275314 Review.
The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase.
Kelley ML, Keiger KE, Lee CJ, Huibregtse JM. Kelley ML, et al. Among authors: huibregtse jm. J Virol. 2005 Mar;79(6):3737-47. doi: 10.1128/JVI.79.6.3737-3747.2005. J Virol. 2005. PMID: 15731267 Free PMC article.
Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.
Gao Q, Kumar A, Singh L, Huibregtse JM, Beaudenon S, Srinivasan S, Wazer DE, Band H, Band V. Gao Q, et al. Among authors: huibregtse jm. Cancer Res. 2002 Jun 1;62(11):3315-21. Cancer Res. 2002. PMID: 12036950
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