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Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine.
Yumibe N, Huie K, Chen KJ, Clement RP, Cayen MN. Yumibe N, et al. Among authors: huie k. Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):420. doi: 10.1159/000237063. Int Arch Allergy Immunol. 1995. PMID: 7613198 No abstract available.
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
Yumibe N, Huie K, Chen KJ, Snow M, Clement RP, Cayen MN. Yumibe N, et al. Among authors: huie k. Biochem Pharmacol. 1996 Jan 26;51(2):165-72. doi: 10.1016/0006-2952(95)02169-8. Biochem Pharmacol. 1996. PMID: 8615885
Synthesis of C3 heteroatom-substituted azetidinones that display potent cholesterol absorption inhibitory activity.
McKittrick BA, Ma K, Huie K, Yumibe N, Davis H Jr, Clader JW, Czarniecki M, McPhail AT. McKittrick BA, et al. Among authors: huie k. J Med Chem. 1998 Feb 26;41(5):752-9. doi: 10.1021/jm970676d. J Med Chem. 1998. PMID: 9513603
Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546).
Glinka T, Huie K, Cho A, Ludwikow M, Blais J, Griffith D, Hecker S, Dudley M. Glinka T, et al. Among authors: huie k. Bioorg Med Chem. 2003 Feb 20;11(4):591-600. doi: 10.1016/s0968-0896(02)00431-5. Bioorg Med Chem. 2003. PMID: 12538024
The relationship between physicochemical properties, in vitro activity and pharmacokinetic profiles of analogues of diamine-containing efflux pump inhibitors.
Watkins WJ, Landaverry Y, L├ęger R, Litman R, Renau TE, Williams N, Yen R, Zhang JZ, Chamberland S, Madsen D, Griffith D, Tembe V, Huie K, Dudley MN. Watkins WJ, et al. Among authors: huie k. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4241-4. doi: 10.1016/j.bmcl.2003.07.030. Bioorg Med Chem Lett. 2003. PMID: 14623009
Loxapine P-glycoprotein interactions in vitro.
Reed A, Huie K, Perloff ES, Cassella JV, Takahashi LH. Reed A, et al. Among authors: huie k. Drug Metab Lett. 2012 Mar;6(1):26-32. doi: 10.2174/187231212800229255. Drug Metab Lett. 2012. PMID: 22300294
Prodrugs of cephalosporin RWJ-333441 (MC-04,546) with improved aqueous solubility.
Hecker SJ, Calkins T, Price ME, Huie K, Chen S, Glinka TW, Dudley MN. Hecker SJ, et al. Among authors: huie k. Antimicrob Agents Chemother. 2003 Jun;47(6):2043-6. doi: 10.1128/aac.47.6.2043-2046.2003. Antimicrob Agents Chemother. 2003. PMID: 12760896 Free PMC article.
SAR studies of anti-MRSA non-zwitterionic 3-heteroarylthiocephems.
Glinka TW, Cho A, Zhang ZJ, Ludwikow M, Griffith D, Huie K, Hecker SJ, Dudley MN, Lee VJ, Chamberland S. Glinka TW, et al. Among authors: huie k. J Antibiot (Tokyo). 2000 Oct;53(10):1045-52. doi: 10.7164/antibiotics.53.1045. J Antibiot (Tokyo). 2000. PMID: 11132949
Effect of smoking on the pharmacokinetics of inhaled loxapine.
Takahashi LH, Huie K, Spyker DA, Fishman RS, Cassella JV. Takahashi LH, et al. Among authors: huie k. Ther Drug Monit. 2014 Oct;36(5):618-23. doi: 10.1097/FTD.0000000000000048. Ther Drug Monit. 2014. PMID: 24937085 Free PMC article.
Validation of HPLC-MS/MS methods for analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human plasma.
Zimmer JS, Needham SR, Christianson CD, Piekarski CM, Sheaff CN, Huie K, Reed AR, Takahashi L. Zimmer JS, et al. Among authors: huie k. Bioanalysis. 2010 Dec;2(12):1989-2000. doi: 10.4155/bio.10.156. Bioanalysis. 2010. PMID: 21110742
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