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mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.
Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, Pearl D, Siddiqui N, Strack S, McGuirk S, St-Pierre J, Larsson O, Topisirovic I, Vali H, McBride HM, Bergeron JJ, Sonenberg N. Morita M, et al. Among authors: hulea l. Mol Cell. 2017 Sep 21;67(6):922-935.e5. doi: 10.1016/j.molcel.2017.08.013. Epub 2017 Sep 14. Mol Cell. 2017. PMID: 28918902 Free article.
Serine deprivation enhances antineoplastic activity of biguanides.
Gravel SP, Hulea L, Toban N, Birman E, Blouin MJ, Zakikhani M, Zhao Y, Topisirovic I, St-Pierre J, Pollak M. Gravel SP, et al. Among authors: hulea l. Cancer Res. 2014 Dec 15;74(24):7521-33. doi: 10.1158/0008-5472.CAN-14-2643-T. Epub 2014 Nov 6. Cancer Res. 2014. PMID: 25377470
Targeting the translation machinery in cancer.
Bhat M, Robichaud N, Hulea L, Sonenberg N, Pelletier J, Topisirovic I. Bhat M, et al. Among authors: hulea l. Nat Rev Drug Discov. 2015 Apr;14(4):261-78. doi: 10.1038/nrd4505. Epub 2015 Mar 6. Nat Rev Drug Discov. 2015. PMID: 25743081 Review.
SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.
Feng Y, Pinkerton AB, Hulea L, Zhang T, Davies MA, Grotegut S, Cheli Y, Yin H, Lau E, Kim H, De SK, Barile E, Pellecchia M, Bosenberg M, Li JL, James B, Hassig CA, Brown KM, Topisirovic I, Ronai ZA. Feng Y, et al. Among authors: hulea l. Cancer Res. 2015 Dec 15;75(24):5211-8. doi: 10.1158/0008-5472.CAN-15-0885. Epub 2015 Nov 24. Cancer Res. 2015. PMID: 26603897 Free PMC article.
Biomedical Potential of mTOR Modulation by Nanoparticles.
Hulea L, Markovic Z, Topisirovic I, Simmet T, Trajkovic V. Hulea L, et al. Trends Biotechnol. 2016 May;34(5):349-353. doi: 10.1016/j.tibtech.2016.01.005. Epub 2016 Feb 15. Trends Biotechnol. 2016. PMID: 26900005
nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.
Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA Jr, St-Pierre J, Pelletier J, Larsson O, Topisirovic I. Gandin V, et al. Among authors: hulea l. Genome Res. 2016 May;26(5):636-48. doi: 10.1101/gr.197566.115. Epub 2016 Mar 16. Genome Res. 2016. PMID: 26984228 Free PMC article.
The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.
Carbonneau M, M Gagné L, Lalonde ME, Germain MA, Motorina A, Guiot MC, Secco B, Vincent EE, Tumber A, Hulea L, Bergeman J, Oppermann U, Jones RG, Laplante M, Topisirovic I, Petrecca K, Huot MÉ, Mallette FA. Carbonneau M, et al. Among authors: hulea l. Nat Commun. 2016 Sep 14;7:12700. doi: 10.1038/ncomms12700. Nat Commun. 2016. PMID: 27624942 Free PMC article.
mTOR-sensitive translation: Cleared fog reveals more trees.
Masvidal L, Hulea L, Furic L, Topisirovic I, Larsson O. Masvidal L, et al. Among authors: hulea l. RNA Biol. 2017 Oct 3;14(10):1299-1305. doi: 10.1080/15476286.2017.1290041. Epub 2017 Feb 10. RNA Biol. 2017. PMID: 28277937 Free PMC article. Review.
28 results