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Safety issues and prospects for future generations of PPAR modulators.
Rubenstrunk A, Hanf R, Hum DW, Fruchart JC, Staels B. Rubenstrunk A, et al. Among authors: hum dw. Biochim Biophys Acta. 2007 Aug;1771(8):1065-81. doi: 10.1016/j.bbalip.2007.02.003. Epub 2007 Feb 24. Biochim Biophys Acta. 2007. PMID: 17428730 Review.
Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.
Ratziu V, Harrison SA, Francque S, Bedossa P, Lehert P, Serfaty L, Romero-Gomez M, Boursier J, Abdelmalek M, Caldwell S, Drenth J, Anstee QM, Hum D, Hanf R, Roudot A, Megnien S, Staels B, Sanyal A; GOLDEN-505 Investigator Study Group. Ratziu V, et al. Gastroenterology. 2016 May;150(5):1147-1159.e5. doi: 10.1053/j.gastro.2016.01.038. Epub 2016 Feb 11. Gastroenterology. 2016. PMID: 26874076 Clinical Trial.
Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.
Gineste R, Sirvent A, Paumelle R, Helleboid S, Aquilina A, Darteil R, Hum DW, Fruchart JC, Staels B. Gineste R, et al. Among authors: hum dw. Mol Endocrinol. 2008 Nov;22(11):2433-47. doi: 10.1210/me.2008-0092. Epub 2008 Aug 28. Mol Endocrinol. 2008. PMID: 18755856
The farnesoid X receptor induces very low density lipoprotein receptor gene expression.
Sirvent A, Claudel T, Martin G, Brozek J, Kosykh V, Darteil R, Hum DW, Fruchart JC, Staels B. Sirvent A, et al. Among authors: hum dw. FEBS Lett. 2004 May 21;566(1-3):173-7. doi: 10.1016/j.febslet.2004.04.026. FEBS Lett. 2004. PMID: 15147890
The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.
Hanf R, Millatt LJ, Cariou B, Noel B, Rigou G, Delataille P, Daix V, Hum DW, Staels B. Hanf R, et al. Among authors: hum dw. Diab Vasc Dis Res. 2014 Nov;11(6):440-7. doi: 10.1177/1479164114548027. Epub 2014 Sep 11. Diab Vasc Dis Res. 2014. PMID: 25212694 Free article.
The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).
Helleboid S, Haug C, Lamottke K, Zhou Y, Wei J, Daix S, Cambula L, Rigou G, Hum DW, Walczak R. Helleboid S, et al. Among authors: hum dw. J Biomol Screen. 2014 Mar;19(3):399-406. doi: 10.1177/1087057113497095. Epub 2013 Jul 29. J Biomol Screen. 2014. PMID: 23896689
Farnesoid X receptor represses hepatic lipase gene expression.
Sirvent A, Verhoeven AJ, Jansen H, Kosykh V, Darteil RJ, Hum DW, Fruchart JC, Staels B. Sirvent A, et al. Among authors: hum dw. J Lipid Res. 2004 Nov;45(11):2110-5. doi: 10.1194/jlr.M400221-JLR200. Epub 2004 Sep 1. J Lipid Res. 2004. PMID: 15342685
The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c.
Jakel H, Nowak M, Moitrot E, Dehondt H, Hum DW, Pennacchio LA, Fruchart-Najib J, Fruchart JC. Jakel H, et al. Among authors: hum dw. J Biol Chem. 2004 Oct 29;279(44):45462-9. doi: 10.1074/jbc.M404744200. Epub 2004 Aug 17. J Biol Chem. 2004. PMID: 15317819
Lesion progression in apoE-deficient mice: implication of chemokines and effect of the AT1 angiotensin II receptor antagonist irbesartan.
Martin G, Dol F, Marés AM, Berezowski V, Staels B, Hum DW, Schaeffer P, Herbert JM. Martin G, et al. Among authors: hum dw. J Cardiovasc Pharmacol. 2004 Feb;43(2):191-9. doi: 10.1097/00005344-200402000-00005. J Cardiovasc Pharmacol. 2004. PMID: 14716205
The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells.
Gizard F, Teissier E, Dufort I, Luc G, Luu-The V, Staels B, Hum DW. Gizard F, et al. Among authors: hum dw. J Mol Endocrinol. 2004 Apr;32(2):557-69. doi: 10.1677/jme.0.0320557. J Mol Endocrinol. 2004. PMID: 15072559
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