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Human Milk Oligosaccharides and Immune System Development.
Plaza-Díaz J, Fontana L, Gil A. Plaza-Díaz J, et al. Nutrients. 2018 Aug 8;10(8):1038. doi: 10.3390/nu10081038. Nutrients. 2018. PMID: 30096792 Free PMC article. Review.
Maternal milk contains compounds that may affect newborn immunity. Among these are a group of oligosaccharides that are synthesized in the mammary gland from lactose; these oligosaccharides have been termed human milk oligosaccharides (HMOs). ...This review begins with short descriptions of the basic structures of HMOs and the gut immune system, continues with the beneficial effects of HMOs shown in cell and animal studies, and it ends with the observational and randomized controlled trials carried out in humans to date, with particular emphasis on their effect on immune system development. ...
Maternal milk contains compounds that may affect newborn immunity. Among these are a group of oligosaccharides that are synthe …
Human breast milk: A review on its composition and bioactivity.
Andreas NJ, Kampmann B, Mehring Le-Doare K. Andreas NJ, et al. Early Hum Dev. 2015 Nov;91(11):629-35. doi: 10.1016/j.earlhumdev.2015.08.013. Epub 2015 Sep 12. Early Hum Dev. 2015. PMID: 26375355 Free article. Review.
These molecules possess diverse roles, both guiding the development of the infants immune system and intestinal microbiota. Orchestrating the development of the microbiota are the human milk oligosaccharides, the synthesis of which are determined by the maternal genotype. ...Understanding the components of breast milk and their functions will allow for the improvement of clinical practices, infant feeding and our understanding of immune responses to infection and vaccination in infants....
These molecules possess diverse roles, both guiding the development of the infants immune system and intestinal microbi …
Human Milk Oligosaccharides Influence Neonatal Mucosal and Systemic Immunity.
Donovan SM, Comstock SS. Donovan SM, et al. Ann Nutr Metab. 2016;69 Suppl 2(Suppl 2):42-51. doi: 10.1159/000452818. Epub 2017 Jan 20. Ann Nutr Metab. 2016. PMID: 28103609 Free PMC article. Review.
The immune system of the infant is functionally immature and naïve. Human milk contains bioactive proteins, lipids, and carbohydrates that protect the newborn and stimulate innate and adaptive immune development. This review will focus on the role human milk oligosaccharides (HMO) play in neonatal gastrointestinal and systemic immune development and function. ...
The immune system of the infant is functionally immature and naïve. Human milk contains bioactive proteins, lipi …
Human Milk Oligosaccharides and the Preterm Infant: A Journey in Sickness and in Health.
Moukarzel S, Bode L. Moukarzel S, et al. Clin Perinatol. 2017 Mar;44(1):193-207. doi: 10.1016/j.clp.2016.11.014. Epub 2016 Dec 27. Clin Perinatol. 2017. PMID: 28159206 Review.
Human milk oligosaccharides (HMOs) are a group of approximately 200 different unconjugated sugar structures in human milk proposed to support infant growth and development. Data from several preclinical animal studies and human cohort studies suggest HMOs reduce preterm infant mortality and morbidity by shaping the gut microbiome and protecting against necrotizing enterocolitis, candidiasis, and several other immune-related diseases. ...
Human milk oligosaccharides (HMOs) are a group of approximately 200 different unconjugated sugar structures in human
Human milk oligosaccharides and development of cow's milk allergy in infants.
Seppo AE, Autran CA, Bode L, Järvinen KM. Seppo AE, et al. J Allergy Clin Immunol. 2017 Feb;139(2):708-711.e5. doi: 10.1016/j.jaci.2016.08.031. Epub 2016 Oct 1. J Allergy Clin Immunol. 2017. PMID: 27702672 Free PMC article.
Human milk oligosaccharides (HMOs) provide a main substrate to help shape the infant's gut microbiota and affect the maturation of the intestinal mucosal immune system. In our cohort, infants that received human milk with low Lacto-N-fucopentaose (LNFP) III concentrations (< 60μM) were more likely to become affected with cow's milk allergy when compared to high LNFP III-containing milk (odds ratio 6.7, 95% CI 2.0-22)....
Human milk oligosaccharides (HMOs) provide a main substrate to help shape the infant's gut microbiota and affect the ma
Sialylated Oligosaccharides and Glycoconjugates of Human Milk. The Impact on Infant and Newborn Protection, Development and Well-Being.
Lis-Kuberka J, Orczyk-Pawiłowicz M. Lis-Kuberka J, et al. Nutrients. 2019 Feb 1;11(2):306. doi: 10.3390/nu11020306. Nutrients. 2019. PMID: 30717166 Free PMC article. Review.
Sialylated human milk glycoconjugates and oligosaccharides enrich the newborn immature immune system and are crucial for their proper development and well-being. ...Conclusion: The review summarizes the current state of knowledge on sialylated human milk oligosaccharides and glycoconjugates, discusses the significance of sialylated structures of human milk in newborn protection and development, and presents the advantages of human milk over infant formula....
Sialylated human milk glycoconjugates and oligosaccharides enrich the newborn immature immune system and …
Chemistry of Human Breast Milk-A Comprehensive Review of the Composition and Role of Milk Metabolites in Child Development.
Garwolińska D, Namieśnik J, Kot-Wasik A, Hewelt-Belka W. Garwolińska D, et al. J Agric Food Chem. 2018 Nov 14;66(45):11881-11896. doi: 10.1021/acs.jafc.8b04031. Epub 2018 Nov 2. J Agric Food Chem. 2018. PMID: 30247884 Review.
Early nutrition has an enormous influence on a child's physiological function, immune system maturation, and cognitive development. Human breast milk (HBM) is recognized as the gold standard for human infant nutrition. According to a WHO report, breastfeeding is considered as an unequaled way of providing ideal food to the infant, which is required for his healthy growth and development. ...
Early nutrition has an enormous influence on a child's physiological function, immune system maturation, and cognitive deve
The Role of Two Human Milk Oligosaccharides, 2'-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition.
Hegar B, Wibowo Y, Basrowi RW, Ranuh RG, Sudarmo SM, Munasir Z, Atthiyah AF, Widodo AD, Supriatmo, Kadim M, Suryawan A, Diana NR, Manoppo C, Vandenplas Y. Hegar B, et al. Pediatr Gastroenterol Hepatol Nutr. 2019 Jul;22(4):330-340. doi: 10.5223/pghn.2019.22.4.330. Epub 2019 Jun 25. Pediatr Gastroenterol Hepatol Nutr. 2019. PMID: 31338308 Free PMC article. Review.
Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. ...Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. ...
Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most a
Human Milk and Allergic Diseases: An Unsolved Puzzle.
Munblit D, Peroni DG, Boix-Amorós A, Hsu PS, Van't Land B, Gay MCL, Kolotilina A, Skevaki C, Boyle RJ, Collado MC, Garssen J, Geddes DT, Nanan R, Slupsky C, Wegienka G, Kozyrskyj AL, Warner JO. Munblit D, et al. Nutrients. 2017 Aug 17;9(8):894. doi: 10.3390/nu9080894. Nutrients. 2017. PMID: 28817095 Free PMC article. Review.
Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known that human milk composition is very complex and contains variable levels of immune active molecules, oligosaccharides, metabolites, vitamins and other nutrients and microbial content. ...In this review, we discuss associations between breastfeeding/human milk composition and allergy development....
Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known t
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