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Page 1
Effects of anti-CD44 monoclonal antibody IM7 carried with chitosan polylactic acid-coated nano-particles on the treatment of ovarian cancer.
Yang Y, Zhao X, Li X, Yan Z, Liu Z, Li Y. Yang Y, et al. Oncol Lett. 2017 Jan;13(1):99-104. doi: 10.3892/ol.2016.5413. Epub 2016 Nov 22. Oncol Lett. 2017. PMID: 28123528 Free PMC article.
The anti-CD44 monoclonal antibody IM7 is effective in treating ovarian cancer; however, its toxicity should not be ignored. ...The in vivo imaging system revealed that PLA-chitosan-IM7 was effective in controlling the development of human ovarian cance …
The anti-CD44 monoclonal antibody IM7 is effective in treating ovarian cancer; however, its toxicity should not be ignored. .. …
Light-triggered, efficient cytosolic release of IM7-saporin targeting the putative cancer stem cell marker CD44 by photochemical internalization.
Bostad M, Kausberg M, Weyergang A, Olsen CE, Berg K, Høgset A, Selbo PK. Bostad M, et al. Mol Pharm. 2014 Aug 4;11(8):2764-76. doi: 10.1021/mp500129t. Epub 2014 Jul 2. Mol Pharm. 2014. PMID: 24960585
We have used the site specific and light-depended drug delivery method photochemical internalization (PCI) to release an immunotoxin (IT), targeting the CD44 receptor, into the cytosol of target cells. The IT consisted of a pan CD44 mAb (clone IM7) bound to t …
We have used the site specific and light-depended drug delivery method photochemical internalization (PCI) to release an immunotoxin (IT), t …
Anti-CD44 monoclonal antibody (IM7) induces murine systemic shock mediated by platelet activating factor.
Tanaka Y, Makiyama Y, Mitsui Y. Tanaka Y, et al. J Autoimmun. 2002 Feb;18(1):9-15. doi: 10.1006/jaut.2001.0559. J Autoimmun. 2002. PMID: 11869042
However, our evidence shows that intravenous administration of the anti-CD44 IgG2b mAb IM7 induces systemic shock in mice. To examine the character of systemic shock, the cutaneous excess vascular permeability was evaluated. ...Y-24180 also ameliorated hematocrit el …
However, our evidence shows that intravenous administration of the anti-CD44 IgG2b mAb IM7 induces systemic shock in mice. To …
CD44 in human placenta: localization and binding to hyaluronic acid.
St Jacques S, Dadi HK, Letarte M. St Jacques S, et al. Placenta. 1993 Jan-Feb;14(1):25-39. doi: 10.1016/s0143-4004(05)80246-2. Placenta. 1993. PMID: 8456087 Free article.
CD44, a receptor for hyaluronic acid (HA), has been identified in the stroma of stem and terminal chorionic villi of human term placenta. ...The binding of CD44 to HA was also inhibited by mAb 50B4 and IM7.8.1, which recognize epitopes of cluster I and …
CD44, a receptor for hyaluronic acid (HA), has been identified in the stroma of stem and terminal chorionic villi of human ter …
Induction of apoptosis by anti-CD44 antibody in human chondrosarcoma cell line SW1353.
Yoshida M, Yasuda T, Hiramitsu T, Ito H, Nakamura T. Yoshida M, et al. Biomed Res. 2008 Feb;29(1):47-52. doi: 10.2220/biomedres.29.47. Biomed Res. 2008. PMID: 18344598 Free article.
This study was aimed to clarify whether anti-CD44 monoclonal antibody induces apoptosis in human chondrosarcoma cell line SW1353. Confocal microscopy revealed that the SW1353 cells expressed CD44 that bound the anti-CD44 antibody IM7. ...In cont …
This study was aimed to clarify whether anti-CD44 monoclonal antibody induces apoptosis in human chondrosarcoma cell line SW13 …
CD44 is not required for poliovirus replication.
Bouchard MJ, Racaniello VR. Bouchard MJ, et al. J Virol. 1997 Apr;71(4):2793-8. doi: 10.1128/JVI.71.4.2793-2798.1997. J Virol. 1997. PMID: 9060634 Free PMC article.
We show here that only AF3 blocks binding of serotype 2 poliovirus to HeLa cells and, in contrast to a previously published report, that the anti-CD44 monoclonal antibodies A3D8 and IM7 are unable to block binding of poliovirus. To determine whether CD44 is i …
We show here that only AF3 blocks binding of serotype 2 poliovirus to HeLa cells and, in contrast to a previously published report, that the …
CD44 expression by leucocytes in rheumatoid arthritis and modulation by specific antibody: implications for lymphocyte adhesion to endothelial cells and synoviocytes in vitro.
Brennan FR, Mikecz K, Glant TT, Jobanputra P, Pinder S, Bavington C, Morrison P, Nuki G. Brennan FR, et al. Scand J Immunol. 1997 Feb;45(2):213-20. doi: 10.1046/j.1365-3083.1997.d01-382.x. Scand J Immunol. 1997. PMID: 9042434 Free article.
Anti-CD44 MoAb IM7 induced the loss of CD44 from mouse leucocytes thereby inhibiting leucocyte migration and joint inflammation in murine arthritis. ...This loss of CD44 was blocked by serine- and metalloprotease inhibitors implying that IM7 ind …
Anti-CD44 MoAb IM7 induced the loss of CD44 from mouse leucocytes thereby inhibiting leucocyte migration and joint infl …
Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine-Induced Synoviocyte Proliferation by Lubricin.
Al-Sharif A, Jamal M, Zhang LX, Larson K, Schmidt TA, Jay GD, Elsaid KA. Al-Sharif A, et al. Arthritis Rheumatol. 2015 Jun;67(6):1503-13. doi: 10.1002/art.39087. Arthritis Rheumatol. 2015. PMID: 25708025 Free PMC article.
The contribution of CD44 was assessed by coincubation with a CD44 antibody (IM7). The antiproliferative effect of rhPRG4 was investigated following treatment of PRG4(-/-) mouse synoviocytes with IL-1beta or TNFalpha in the presence or absence of IM7. R …
The contribution of CD44 was assessed by coincubation with a CD44 antibody (IM7). The antiproliferative effect of rhPRG …
Epitope specificity of CD44 for monoclonal antibody-dependent facilitation of marrow engraftment in a canine model.
Sandmaier BM, Storb R, Bennett KL, Appelbaum FR, Santos EB. Sandmaier BM, et al. Blood. 1998 May 1;91(9):3494-502. Blood. 1998. PMID: 9558410 Free article.
However, in vitro binding of S5 caused a conformational change in CD44, which allowed increased hyaluronan binding. Then, we reexamined the in vivo model of marrow transplantation and compared results with MoAb S5 to those with two other anti-CD44 MoAbs, I …
However, in vitro binding of S5 caused a conformational change in CD44, which allowed increased hyaluronan binding. Then, we r …
Modulation of hyaluronan production by CD44 positive glioma cells.
Wiranowska M, Ladd S, Moscinski LC, Hill B, Haller E, Mikecz K, Plaas A. Wiranowska M, et al. Int J Cancer. 2010 Aug 1;127(3):532-42. doi: 10.1002/ijc.25085. Int J Cancer. 2010. PMID: 19957333 Free PMC article.
Production of HA by CD44 positive mouse G26 and human U373 glioma cell lines was evaluated and compared to that of a CD44 positive mouse fibroblast-like L929 cell line. ...IM7 treatment of human U373 glioma cells resulted in over 50% decrease of …
Production of HA by CD44 positive mouse G26 and human U373 glioma cell lines was evaluated and compared to that of a CD44 …
23 results