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31 results

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Page 1
Anti-CD47 monoclonal antibody (B6H12) impairs the maturation and function of human dendritic cells.
Yu J, Lin MF. Yu J, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Apr;13(2):192-7. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005. PMID: 15854275
To investigate the influence and mechanisms of CD47 engagement by its soluble mAb B6H12 on the maturation and function of cultured dendritic cells (DCs), monocyte-derived DCs were propagated in granulocyte-macrophage colony stimulating factor (GM-CSF) combined with …
To investigate the influence and mechanisms of CD47 engagement by its soluble mAb B6H12 on the maturation and function of cult …
A fully human anti-CD47 blocking antibody with therapeutic potential for cancer.
Zeng D, Sun Q, Chen A, Fan J, Yang X, Xu L, Du P, Qiu W, Zhang W, Wang S, Sun Z. Zeng D, et al. Oncotarget. 2016 Dec 13;7(50):83040-83050. doi: 10.18632/oncotarget.13349. Oncotarget. 2016. PMID: 27863402 Free PMC article.
In this study, we reported the isolation of a fully human anti-CD47 blocking antibody, ZF1, from a phage display library. ZF1 displayed high specificity and affinity for CD47 protein, which were comparable to those for humanized anti-CD47 blocking anti …
In this study, we reported the isolation of a fully human anti-CD47 blocking antibody, ZF1, from a phage display library. ZF1 …
Structure of the human marker of self 5-transmembrane receptor CD47.
Fenalti G, Villanueva N, Griffith M, Pagarigan B, Lakkaraju SK, Huang RY, Ladygina N, Sharma A, Mikolon D, Abbasian M, Johnson J, Hadjivassiliou H, Zhu D, Chamberlain PP, Cho H, Hariharan K. Fenalti G, et al. Nat Commun. 2021 Sep 1;12(1):5218. doi: 10.1038/s41467-021-25475-w. Nat Commun. 2021. PMID: 34471125 Free PMC article.
We present the crystal structure of full length CD47 bound to the function-blocking antibody B6H12. CD47 ECD is tethered to the TM domain via a six-residue peptide linker ((114)RVVSWF(119)) that forms an extended loop (SWF loop), with the fundamental role of …
We present the crystal structure of full length CD47 bound to the function-blocking antibody B6H12. CD47 ECD is tethere …
Binding Mechanism of CD47 with SIRPalpha Variants and Its Antibody: Elucidated by Molecular Dynamics Simulations.
Huang K, Liu Y, Wen S, Zhao Y, Ding H, Liu H, Kong DX. Huang K, et al. Molecules. 2023 Jun 7;28(12):4610. doi: 10.3390/molecules28124610. Molecules. 2023. PMID: 37375166 Free PMC article.
The calculated binding free energy of CD47-B6H12.2 is lower than that of CD47-SIRPalphav1 and CD47-SIRPalphav2 in all the three simulations, indicating that CD47-B6H12.2 has a higher binding affinity than the other two complexes. ...The e …
The calculated binding free energy of CD47-B6H12.2 is lower than that of CD47-SIRPalphav1 and CD47-SIRPalphav2 i …
A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer.
Kaur S, Elkahloun AG, Singh SP, Chen QR, Meerzaman DM, Song T, Manu N, Wu W, Mannan P, Garfield SH, Roberts DD. Kaur S, et al. Oncotarget. 2016 Mar 1;7(9):10133-52. doi: 10.18632/oncotarget.7100. Oncotarget. 2016. PMID: 26840086 Free PMC article.
By inducing inhibitory SIRPalpha signaling, elevated CD47 expression by some cancers prevents macrophage phagocytosis. The anti-human CD47 antibody B6H12 inhibits tumor growth in several xenograft models, presumably by preventing SIRPalpha engagement. …
By inducing inhibitory SIRPalpha signaling, elevated CD47 expression by some cancers prevents macrophage phagocytosis. The anti-hu …
Porcine signal regulatory protein alpha binds to human CD47 to inhibit phagocytosis: Implications for human hematopoietic stem cell transplantation into severe combined immunodeficient pigs.
Boettcher AN, Cunnick JE, Powell EJ, Egner TK, Charley SE, Loving CL, Tuggle CK. Boettcher AN, et al. Xenotransplantation. 2019 Mar;26(2):e12466. doi: 10.1111/xen.12466. Epub 2018 Oct 12. Xenotransplantation. 2019. PMID: 30311702 Free PMC article.
Blocking phagocytosis assays were performed by incubating human RBCs with anti-human CD47 blocking antibody B6H12, non-blocking antibody 2D3, and nonspecific IgG1 antibody and exposing to human or porcine monocytes. ...When human RBCs wer …
Blocking phagocytosis assays were performed by incubating human RBCs with anti-human CD47 blocking antibody B6H12 …
Integrin-associated protein/CD47 regulates motile activity in human B-cell lines through CDC42.
Yoshida H, Tomiyama Y, Ishikawa J, Oritani K, Matsumura I, Shiraga M, Yokota T, Okajima Y, Ogawa M, Miyagawa Ji, Nishiura T, Matsuzawa Y. Yoshida H, et al. Blood. 2000 Jul 1;96(1):234-41. Blood. 2000. PMID: 10891456 Free article.
However, in B-lymphocytes that express beta1 integrins but few beta3 integrins, the roles of IAP/CD47 remain to be determined. Cross-linking of IAP/CD47 by the immobilized anti-IAP/CD47 monoclonal antibody (mAb) B6H12, but not 2D3, produced signals to …
However, in B-lymphocytes that express beta1 integrins but few beta3 integrins, the roles of IAP/CD47 remain to be determined. Cross- …
Proinflammatory polarization strongly reduces human macrophage in vitro phagocytosis of tumor cells in response to CD47 blockade.
Antonsen KW, Jensen AG, Carstensen M, Nejsum LN, Sorensen BS, Etzerodt A, Moestrup SK, Møller HJ. Antonsen KW, et al. Eur J Immunol. 2024 Jul;54(7):e2350824. doi: 10.1002/eji.202350824. Epub 2024 Apr 9. Eur J Immunol. 2024. PMID: 38593339 Free article.
Using both flow cytometry-based and fluorescence live-cell imaging-based phagocytosis assays, we observed that mouse monoclonal anti-CD47 antibody (B6H12) induced monocyte-derived macrophage phagocytosis of cancer cells in vitro. ...However, matrix metalloproteinase …
Using both flow cytometry-based and fluorescence live-cell imaging-based phagocytosis assays, we observed that mouse monoclonal anti-CD47 …
CD47-ligation induced cell death in T-acute lymphoblastic leukemia.
Leclair P, Liu CC, Monajemi M, Reid GS, Sly LM, Lim CJ. Leclair P, et al. Cell Death Dis. 2018 May 1;9(5):544. doi: 10.1038/s41419-018-0601-2. Cell Death Dis. 2018. PMID: 29748606 Free PMC article.
A lesser known consequence of CD47 receptor ligation is the direct induction of tumour cell death. While several mAbs and their derivatives with this property have been studied, the best characterized is the commercially available mAb B6H12, which requires immobiliz …
A lesser known consequence of CD47 receptor ligation is the direct induction of tumour cell death. While several mAbs and their deriv …
[Effect of soluble anti-CD47 monoclonal antibody on the differentiation and function of human dendritic cells].
Lin MF, Yu J, Yan LX. Lin MF, et al. Zhonghua Xue Ye Xue Za Zhi. 2004 Dec;25(12):709-12. Zhonghua Xue Ye Xue Za Zhi. 2004. PMID: 15730710 Chinese.
OBJECTIVE: To explore the influences of anti-CD47 monoclonal antibody (mAb) B6H12 on the differentiation and function of cultured dendritic cells (DCs). METHODS: Human peripheral monocyte derived DCs were propagated with granulocyte-macrophage colony-stimulat …
OBJECTIVE: To explore the influences of anti-CD47 monoclonal antibody (mAb) B6H12 on the differentiation and function of cultu …
31 results