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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 8
1998 10
1999 9
2000 5
2001 6
2002 5
2003 8
2004 5
2005 3
2006 3
2007 6
2008 5
2009 2
2010 3
2011 2
2012 2
2013 3
2014 5
2015 2
2016 1
2017 1
2018 1
2019 2
2020 4
2022 1
2024 3
2026 0

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100 results

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Page 1
Antibody to CD14 like CXCR4-specific antibody 12G5 could inhibit CXCR4-dependent chemotaxis and HIV Env-mediated cell fusion.
Yang H, Lan C, Xiao Y, Chen YH. Yang H, et al. Immunol Lett. 2003 Jul 3;88(1):27-30. doi: 10.1016/s0165-2478(03)00048-8. Immunol Lett. 2003. PMID: 12853157
The anti-CD14 mAb TUK4 like CXCR4-specific mAb 12G5 could block SDF-induced chemotaxis of U937 cells in a dose-dependent manner, while another CD14-specific mAb UCHM-1 did not show any activity. ...These results provided experimental evidence for existence of close …
The anti-CD14 mAb TUK4 like CXCR4-specific mAb 12G5 could block SDF-induced chemotaxis of U937 cells in a dose-dependent manne …
CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells.
Ieranò C, Santagata S, Napolitano M, Guardia F, Grimaldi A, Antignani E, Botti G, Consales C, Riccio A, Nanayakkara M, Barone MV, Caraglia M, Scala S. Ieranò C, et al. Cell Death Dis. 2014 Jul 3;5(7):e1310. doi: 10.1038/cddis.2014.269. Cell Death Dis. 2014. PMID: 24991762 Free PMC article.
The mTOR activation was specifically inhibited by CXCR4 antagonists (AMD3100, anti-CXCR4-12G5 and Peptide R, a newly developed CXCR4 antagonist) and CXCR7 antagonists (anti-CXCR7-12G8 and CCX771, CXCR7 inhibitor). To investigate the functional role of …
The mTOR activation was specifically inhibited by CXCR4 antagonists (AMD3100, anti-CXCR4-12G5 and Peptide R, a newly de …
Structural optimization of aminopyrimidine-based CXCR4 antagonists.
Zhu F, Wang Y, Du Q, Ge W, Li Z, Wang X, Fu C, Luo L, Tian S, Ma H, Zheng J, Zhang Y, Sun X, He S, Zhang X. Zhu F, et al. Eur J Med Chem. 2020 Feb 1;187:111914. doi: 10.1016/j.ejmech.2019.111914. Epub 2019 Nov 26. Eur J Med Chem. 2020. PMID: 31806538
Structural optimization of aminopyrimidine-based CXCR4 antagonists is reported. The optimization is guided by molecular docking studies based on available CXCR4-small molecule crystal complex. The optimization identifies a number of compounds with improved receptor …
Structural optimization of aminopyrimidine-based CXCR4 antagonists is reported. The optimization is guided by molecular docking studi …
A monoclonal antibody (12G5) directed against CXCR-4 inhibits infection with the dual-tropic human immunodeficiency virus type 1 isolate HIV-1(89.6) but not the T-tropic isolate HIV-1(HxB).
Strizki JM, Turner JD, Collman RG, Hoxie J, González-Scarano F. Strizki JM, et al. J Virol. 1997 Jul;71(7):5678-83. doi: 10.1128/JVI.71.7.5678-5683.1997. J Virol. 1997. PMID: 9188648 Free PMC article.
We used a monoclonal antibody (12G5) directed against an extracellular domain of CXCR-4 to investigate the role of this receptor in infection of immortalized lymphoid cell lines, peripheral blood mononuclear cells (PBMCs), and primary brain microglia with a dual-tropic str …
We used a monoclonal antibody (12G5) directed against an extracellular domain of CXCR-4 to investigate the role of this receptor in i …
Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent.
McKnight A, Wilkinson D, Simmons G, Talbot S, Picard L, Ahuja M, Marsh M, Hoxie JA, Clapham PR. McKnight A, et al. J Virol. 1997 Feb;71(2):1692-6. doi: 10.1128/JVI.71.2.1692-1696.1997. J Virol. 1997. PMID: 8995702 Free PMC article.
We show here that a novel mouse monoclonal antibody (12G5) that recognizes CXCR4 blocked cell-to-cell fusion and cell free-virus infection of CXCR4+ CD4+ RD rhabdomyosarcoma cells by seven HIV-1 and HIV-2 strains that had various cell tropisms for different C …
We show here that a novel mouse monoclonal antibody (12G5) that recognizes CXCR4 blocked cell-to-cell fusion and cell free-vir …
Co-expression of CXCR4/fusin and galactosylceramide in the human intestinal epithelial cell line HT-29.
Delézay O, Koch N, Yahi N, Hammache D, Tourres C, Tamalet C, Fantini J. Delézay O, et al. AIDS. 1997 Sep;11(11):1311-8. doi: 10.1097/00002030-199711000-00004. AIDS. 1997. PMID: 9302439
OBJECTIVE: To detect the expression CXCR4/fusin in human intestinal epithelial cells and to assess its potential role in the pathway of HIV-1 infection mediated by the alternative gp120 receptor galactosylceramide (GalCer). METHODS: GalCer+ (HT-29, HT-29/CD4+) and G …
OBJECTIVE: To detect the expression CXCR4/fusin in human intestinal epithelial cells and to assess its potential role in the p …
Characterization and application of two novel monoclonal antibodies against human CXCR4: cell proliferation and migration regulation for glioma cell line in vitro by CXCR4/SDF-1alpha signal.
Cheng Z, Zhou S, Wang X, Xie F, Wu H, Liu G, Wang Q, Chen Y, Hu Y, Lu B, Zhang X. Cheng Z, et al. Hybridoma (Larchmt). 2009 Feb;28(1):33-41. doi: 10.1089/hyb.2008.0069. Hybridoma (Larchmt). 2009. PMID: 19239368
Many published reports have highlighted CXCR4 as a target in HIV infection and in cancer metastasis. In this study, we generated two specific monoclonal antibodies (MAbs 6H7 and 7D4) against human CXCR4 and found that they could recognize different antigen ep …
Many published reports have highlighted CXCR4 as a target in HIV infection and in cancer metastasis. In this study, we generated two …
CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice.
Brennecke P, Arlt MJ, Campanile C, Husmann K, Gvozdenovic A, Apuzzo T, Thelen M, Born W, Fuchs B. Brennecke P, et al. Clin Exp Metastasis. 2014 Mar;31(3):339-49. doi: 10.1007/s10585-013-9632-3. Epub 2014 Jan 4. Clin Exp Metastasis. 2014. PMID: 24390633 Free PMC article.
Studies in experimental OS metastasis models pointed to the CXCR4/CXCL12 homing axis as a novel target for OS metastasis-suppressive treatment. The present study investigated for the first time the CXCR4-blocking principle in a spontaneously metastasizing human …
Studies in experimental OS metastasis models pointed to the CXCR4/CXCL12 homing axis as a novel target for OS metastasis-suppressive …
Antigenically distinct conformations of CXCR4.
Baribaud F, Edwards TG, Sharron M, Brelot A, Heveker N, Price K, Mortari F, Alizon M, Tsang M, Doms RW. Baribaud F, et al. J Virol. 2001 Oct;75(19):8957-67. doi: 10.1128/JVI.75.19.8957-8967.2001. J Virol. 2001. PMID: 11533159 Free PMC article.
The major human immunodeficiency virus type 1 (HIV-1) coreceptors are the chemokine receptors CCR5 and CXCR4. ...In addition, the MAb most commonly used to study CXCR4 expression, 12G5, recognizes only a subpopulation of CXCR4 molecules on all p …
The major human immunodeficiency virus type 1 (HIV-1) coreceptors are the chemokine receptors CCR5 and CXCR4. ...In addition, …
Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist.
Princen K, Hatse S, Vermeire K, Aquaro S, De Clercq E, Gerlach LO, Rosenkilde M, Schwartz TW, Skerlj R, Bridger G, Schols D. Princen K, et al. J Virol. 2004 Dec;78(23):12996-3006. doi: 10.1128/JVI.78.23.12996-13006.2004. J Virol. 2004. PMID: 15542651 Free PMC article.
AMD3451 dose-dependently inhibited the intracellular Ca(2+) signaling induced by the CXCR4 ligand CXCL12 in T-lymphocytic cells and in CXCR4-transfected cells, as well as the Ca(2+) flux induced by the CCR5 ligands CCL5, CCL3, and CCL4 in CCR5-transfected cells. ... …
AMD3451 dose-dependently inhibited the intracellular Ca(2+) signaling induced by the CXCR4 ligand CXCL12 in T-lymphocytic cells and i …
100 results