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Year Number of Results
1997 1
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2006 6
2007 9
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171 results

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Page 1
ADAM10-cleaved ephrin-A5 contributes to prostate cancer metastasis.
Cai C, Zhang M, Liu L, Zhang H, Guo Y, Lan T, Xu Y, Ma P, Li S. Cai C, et al. Cell Death Dis. 2022 May 12;13(5):453. doi: 10.1038/s41419-022-04893-8. Cell Death Dis. 2022. PMID: 35551177 Free PMC article.
We found that ectopic expression of ADAM10 not only significantly facilitated cell proliferation, migration, invasion, and inhibited apoptosis, but also could specifically hydrolyze ephrin-A5 and release the ephrin-A5 soluble ectodomain into extracellu …
We found that ectopic expression of ADAM10 not only significantly facilitated cell proliferation, migration, invasion, and inhibited apoptos …
EphA2 and ephrin-A5 are not a receptor-ligand pair in the ocular lens.
Cheng C, Fowler VM, Gong X. Cheng C, et al. Exp Eye Res. 2017 Sep;162:9-17. doi: 10.1016/j.exer.2017.06.016. Epub 2017 Jun 23. Exp Eye Res. 2017. PMID: 28648759 Free PMC article.
To test whether abnormal signaling mechanisms may play a role in cataractogenesis in ephrin-A5(-/-) or EphA2(-/-) lenses, we generated EphA2 and ephrin-A5 double knockout (DKO) mice. ...The DKO lens phenotype rules out abnormal signaling by EphA2 in …
To test whether abnormal signaling mechanisms may play a role in cataractogenesis in ephrin-A5(-/-) or EphA2(-/-) lenses, we g …
The role of ephrin-A2 and ephrin-A5 in sensorimotor control and gating.
Yates NJ, Martin-Iverson MT, Rodger J. Yates NJ, et al. Behav Brain Res. 2014 Dec 15;275:225-33. doi: 10.1016/j.bbr.2014.08.061. Epub 2014 Sep 6. Behav Brain Res. 2014. PMID: 25200515 Free article.
Analysis of the ASR and PPI in ephrin-A2 and/or ephrin-A5 knock-out mice revealed that both genes play distinct roles in mediating ASR circuits, but are unlikely to play a role in PPI. Knock-out of either gene resulted in robust changes in startle response ma …
Analysis of the ASR and PPI in ephrin-A2 and/or ephrin-A5 knock-out mice revealed that both genes play distinct roles i …
Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis.
Rué L, Oeckl P, Timmers M, Lenaerts A, van der Vos J, Smolders S, Poppe L, de Boer A, Van Den Bosch L, Van Damme P, Weishaupt JH, Ludolph AC, Otto M, Robberecht W, Lemmens R. Rué L, et al. Acta Neuropathol Commun. 2019 Jul 12;7(1):114. doi: 10.1186/s40478-019-0759-6. Acta Neuropathol Commun. 2019. PMID: 31300041 Free PMC article.
These findings suggest ephrin-A5 as a modifier of disease progression that might play a role in the later stages of the disease. ...In summary, we identified reduced expression of ephrin-A5 to accelerate disease progression in a mouse model of ALS as w …
These findings suggest ephrin-A5 as a modifier of disease progression that might play a role in the later stages of the diseas …
Roles of Eph-Ephrin Signaling in the Eye Lens Cataractogenesis, Biomechanics, and Homeostasis.
Murugan S, Cheng C. Murugan S, et al. Front Cell Dev Biol. 2022 Feb 28;10:852236. doi: 10.3389/fcell.2022.852236. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35295853 Free PMC article. Review.
In particular, dysfunction of the receptor EphA2 or the ligand ephrin-A5 lead to a variety of congenital and age-related cataracts, defined as any opacity in the lens, in human patients. ...This review summarizes the roles of EphA2 and ephrin-A5 …
In particular, dysfunction of the receptor EphA2 or the ligand ephrin-A5 lead to a variety of congenital and age-related catar …
Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion.
Fujiwara H, Nishioka Y, Matsumoto H, Suginami K, Horie A, Tani H, Matsumura N, Baba T, Sato Y, Araki Y, Konishi I. Fujiwara H, et al. Int J Gynecol Cancer. 2013 Mar;23(3):576-82. doi: 10.1097/IGC.0b013e3182849e36. Int J Gynecol Cancer. 2013. PMID: 23429488
Previously, the Eph-ephrin system was reported to regulate human extravillous trophoblast invasion. ...RESULTS: By reverse transcription-polymerase chain reaction, mRNAs of Eph A1, A2, and A4 and ephrin A1, A4, and A5 were detected on JEG-3 cells. In M …
Previously, the Eph-ephrin system was reported to regulate human extravillous trophoblast invasion. ...RESULTS: By reverse tra …
Crystal structure of the human ephrin-A5 ectodomain.
Nikolov D, Li C, Lackmann M, Jeffrey P, Himanen J. Nikolov D, et al. Protein Sci. 2007 May;16(5):996-1000. doi: 10.1110/ps.062665807. Epub 2007 Mar 30. Protein Sci. 2007. PMID: 17400922 Free PMC article.
Overall, ephrin-A5 is structurally very similar to ephrin-B1 and ephrin-B2 but, unlike ephrin-B2, it does not show dimerization either in solution or in the crystals. Comparing free ephrin-A5 to the previously published structure o …
Overall, ephrin-A5 is structurally very similar to ephrin-B1 and ephrin-B2 but, unlike ephrin-B2, it does …
Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival.
Giaginis C, Tsoukalas N, Bournakis E, Alexandrou P, Kavantzas N, Patsouris E, Theocharis S. Giaginis C, et al. BMC Clin Pathol. 2014 Feb 4;14(1):8. doi: 10.1186/1472-6890-14-8. BMC Clin Pathol. 2014. PMID: 24495444 Free PMC article.
BACKGROUND: Ephrin (Eph) receptors are frequently overexpressed in a wide variety of human malignant tumors, being associated with tumor growth, invasion, metastasis and angiogenesis. The present study aimed to evaluate the clinical significance of EphA1, A4, A5 …
BACKGROUND: Ephrin (Eph) receptors are frequently overexpressed in a wide variety of human malignant tumors, being associated …
Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis.
Varelias A, Koblar SA, Cowled PA, Carter CD, Clayer M. Varelias A, et al. Cancer. 2002 Aug 15;95(4):862-9. doi: 10.1002/cncr.10749. Cancer. 2002. PMID: 12209731 Free article.
It has been reported that eph receptor protein tyrosine kinases and their ligands, ephrins, are associated with increased tumorigenicity in patients with breast carcinoma and melanoma. The expression and role of eph/ephrins in human osteosarcoma has not yet been characteri …
It has been reported that eph receptor protein tyrosine kinases and their ligands, ephrins, are associated with increased tumorigenicity in …
Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions.
Gerstmann K, Pensold D, Symmank J, Khundadze M, Hübner CA, Bolz J, Zimmer G. Gerstmann K, et al. Development. 2015 Jan 1;142(1):140-50. doi: 10.1242/dev.104927. Epub 2014 Dec 5. Development. 2015. PMID: 25480914
Here, we provide evidence for a subcortical contribution to cortical progenitor regulation by thalamic axons via ephrin A5-EphA4 interactions. Ephrin A5 is expressed by thalamic axons and represents a high-affinity ligand for EphA4 receptors detected i …
Here, we provide evidence for a subcortical contribution to cortical progenitor regulation by thalamic axons via ephrin A5-Eph …
171 results