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Year Number of Results
1981 1
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1983 1
1984 4
1985 1
1987 2
1988 1
1989 1
1991 2
1992 9
1993 12
1994 20
1995 21
1996 33
1997 37
1998 33
1999 41
2000 34
2001 45
2002 56
2003 48
2004 58
2005 70
2006 65
2007 75
2008 64
2009 73
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1,487 results

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Page 1
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca(2+)-FOXO1 pathway.
Huang JC, Duan CC, Jin S, Sheng CB, Wang YS, Yue ZP, Guo B. Huang JC, et al. Int J Biol Sci. 2022 Feb 28;18(5):2047-2059. doi: 10.7150/ijbs.69343. eCollection 2022. Int J Biol Sci. 2022. PMID: 35342363 Free PMC article.
Furthermore, HB-EGF transduced intracellular downstream cAMP-PKA signaling to promote the phosphorylation of JNK and ERK whose blockage impeded the induction of HB-EGF on estrogen secretion. Meanwhile, HB-EGF enhanced the accumulation of …
Furthermore, HB-EGF transduced intracellular downstream cAMP-PKA signaling to promote the phosphorylation of JNK and ERK whose …
Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation.
Zhou L, Zhou W, Joseph AM, Chu C, Putzel GG, Fang B, Teng F, Lyu M, Yano H, Andreasson KI, Mekada E, Eberl G, Sonnenberg GF. Zhou L, et al. Nat Immunol. 2022 Feb;23(2):251-261. doi: 10.1038/s41590-021-01110-0. Epub 2022 Jan 31. Nat Immunol. 2022. PMID: 35102343 Free PMC article.
This occurs independent of interleukin-22 (IL-22), and we identify that ILC3s are a dominant source of heparin-binding epidermal growth factor-like growth factor (HB-EGF). ...Finally, human ILC3s produce HB- …
This occurs independent of interleukin-22 (IL-22), and we identify that ILC3s are a dominant source of heparin-binding epiderm …
HB-EGF upregulates StAR expression and stimulates progesterone production through ERK1/2 signaling in human granulosa-lutein cells.
Cheng JC, Han X, Meng Q, Guo Y, Liu B, Song T, Jia Y, Fang L, Sun YP. Cheng JC, et al. Cell Commun Signal. 2022 Oct 25;20(1):166. doi: 10.1186/s12964-022-00983-4. Cell Commun Signal. 2022. PMID: 36284301 Free PMC article.
BACKGROUND: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) belongs to the epidermal growth factor (EGF) family of growth factors. HB-EGF and its receptors, epide …
BACKGROUND: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) belo …
Antiproliferative and apoptotic effects of anti-human HB-EGF neutralizing polyclonal antibodies in vitro.
Siromolot AA, Krynina OI, Kolybo DV, Komisarenko SV. Siromolot AA, et al. Exp Oncol. 2020 Mar;42(1):25-30. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-1.14145. Exp Oncol. 2020. PMID: 32231194
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the epidermal growth factor family and has a variety of physiological and pathophysiological functions. ...RESULTS: Rabbit poly …
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of t …
Eicosanoids and HB-EGF/EGFR in cancer.
Yang CC, Chang KW. Yang CC, et al. Cancer Metastasis Rev. 2018 Sep;37(2-3):385-395. doi: 10.1007/s10555-018-9746-9. Cancer Metastasis Rev. 2018. PMID: 29936588 Review.
They include both the COX-derived prostaglandins and the LOX-derived leukotrienes. Furthermore, the epidermal growth factor receptor (EGFR) pathways family of receptor tyrosine kinases also are known to play a central role in the tumorigenesis. ...Although combined …
They include both the COX-derived prostaglandins and the LOX-derived leukotrienes. Furthermore, the epidermal growth factor re …
Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer.
Cigliola V, Shoffner A, Lee N, Ou J, Gonzalez TJ, Hoque J, Becker CJ, Han Y, Shen G, Faw TD, Abd-El-Barr MM, Varghese S, Asokan A, Poss KD. Cigliola V, et al. Nat Commun. 2023 Aug 11;14(1):4857. doi: 10.1038/s41467-023-40486-5. Nat Commun. 2023. PMID: 37567873 Free PMC article.
Local recombinant human HB-EGF delivery alters ependymal cell cycling and tissue bridging, enhancing functional regeneration. ...Our results identify Hb-egf as a neurogenic factor necessary for innate spinal cord regeneration and suggest …
Local recombinant human HB-EGF delivery alters ependymal cell cycling and tissue bridging, enhancing functional regener …
Anti-Human HB-EGF Monoclonal Antibody.
[No authors listed] [No authors listed] Monoclon Antib Immunodiagn Immunother. 2016 Apr;35(2):123. doi: 10.1089/mab.2016.0011. Monoclon Antib Immunodiagn Immunother. 2016. PMID: 27097072 No abstract available.
Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding.
Hamaoka M, Chinen I, Murata T, Takashima S, Iwamoto R, Mekada E. Hamaoka M, et al. J Biochem. 2010 Jul;148(1):55-69. doi: 10.1093/jb/mvq033. Epub 2010 Mar 23. J Biochem. 2010. PMID: 20332144
HB-EGF is a member of the EGF family of growth factors that bind and activate the EGF receptor. ...In this study, we newly generated seven clones of hybridoma-derived mAbs by immunizing HB-EGF null mice with recombinant human …
HB-EGF is a member of the EGF family of growth factors that bind and activate the EGF receptor. ...In thi …
A novel anti-human HB-EGF monoclonal antibody with multiple antitumor mechanisms against ovarian cancer cells.
Miyamoto S, Iwamoto R, Furuya A, Takahashi K, Sasaki Y, Ando H, Yotsumoto F, Yoneda T, Hamaoka M, Yagi H, Murakami T, Hori S, Shitara K, Mekada E. Miyamoto S, et al. Clin Cancer Res. 2011 Nov 1;17(21):6733-41. doi: 10.1158/1078-0432.CCR-11-1029. Epub 2011 Sep 14. Clin Cancer Res. 2011. PMID: 21918176
PURPOSE: Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family and plays a pivotal role in tumor progression in ovarian cancer. ...EXPERIMENTAL DESIGN: W …
PURPOSE: Heparin-binding epidermal growth factor (EGF)-like growth factor (HB …
First-in-human study of the anti-HB-EGF antibody U3-1565 in subjects with advanced solid tumors.
Moore KN, Bendell JC, LoRusso PM, Olszanski AJ, Zwick-Wallasch E, Jansen M, Vandell AG, Senaldi G. Moore KN, et al. Invest New Drugs. 2019 Feb;37(1):147-158. doi: 10.1007/s10637-018-0646-1. Epub 2018 Jul 28. Invest New Drugs. 2019. PMID: 30056611 Free PMC article. Clinical Trial.
U3-1565 is a monoclonal antibody directed against heparin-binding epidermal growth factor-like growth factor (HB-EGF), which mediates angiogenesis via induction of vascular endothelial growth factor (VEGF-A). T …
U3-1565 is a monoclonal antibody directed against heparin-binding epidermal growth factor-like growth …
1,487 results