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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 7
1997 14
1998 18
1999 37
2000 38
2001 55
2002 53
2003 68
2004 65
2005 93
2006 95
2007 81
2008 87
2009 116
2010 130
2011 143
2012 136
2013 137
2014 135
2015 148
2016 166
2017 186
2018 156
2019 187
2020 182
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2022 107
2023 91
2024 24

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2,564 results

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Page 1
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis.
Hu Q, Ecker M. Hu Q, et al. Int J Mol Sci. 2021 Feb 9;22(4):1742. doi: 10.3390/ijms22041742. Int J Mol Sci. 2021. PMID: 33572320 Free PMC article. Review.
However, the detailed molecular mechanisms of OA initiation and progression remain elusive, and, currently, there are no interventions available to restore degraded cartilage. This review fully illustrates the involvement of MMP-13 in the initiation and progression …
However, the detailed molecular mechanisms of OA initiation and progression remain elusive, and, currently, there are no interventions avail …
The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review.
Mehana EE, Khafaga AF, El-Blehi SS. Mehana EE, et al. Life Sci. 2019 Oct 1;234:116786. doi: 10.1016/j.lfs.2019.116786. Epub 2019 Aug 22. Life Sci. 2019. PMID: 31445934 Review.
The aim of the present review is to shed light on the general role of MMPs, with special emphasis on MMP-13, in the induction of OA and the general basis of OA treatment. ...Selective inhibition of MMP-13 seems to be an attractive therapeutic strategy. …
The aim of the present review is to shed light on the general role of MMPs, with special emphasis on MMP-13, in the induction …
Expression of MMP-13 in human temporomandibular joint disc derangement and osteoarthritis.
Perotto JH, Camejo FA, Doetzer AD, Almeida LE, Azevedo M, Olandoski M, Noronha L, Trevilatto PC. Perotto JH, et al. Cranio. 2018 May;36(3):161-166. doi: 10.1080/08869634.2017.1315511. Epub 2017 Apr 26. Cranio. 2018. PMID: 28446077
OBJECTIVE: MMP-13 performs digestion of collagen, which is a primary component of the temporomandibular joint (TMJ) articular disc. ...CONCLUSION: This study suggests MMP-13 is not significantly involved in collagen degradation in human TMJ disc …
OBJECTIVE: MMP-13 performs digestion of collagen, which is a primary component of the temporomandibular joint (TMJ) articular …
PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes.
Ma CH, Wu CH, Jou IM, Tu YK, Hung CH, Hsieh PL, Tsai KL. Ma CH, et al. Redox Biol. 2018 Apr;14:72-81. doi: 10.1016/j.redox.2017.08.011. Epub 2017 Aug 24. Redox Biol. 2018. PMID: 28869834 Free PMC article.
Although the elevated expression of PKR (double stranded RNA-dependent protein kinase) and MMP-13 (collagenase-3) have been indicated to play pivotal roles in the pathogenesis of OA, the exact mechanism underlying the regulation of MMP-13 by PKR follow …
Although the elevated expression of PKR (double stranded RNA-dependent protein kinase) and MMP-13 (collagenase-3) have been in …
Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors.
Balbín M, Pendás AM, Uría JA, Jiménez MG, Freije JP, López-Otín C. Balbín M, et al. APMIS. 1999 Jan;107(1):45-53. doi: 10.1111/j.1699-0463.1999.tb01525.x. APMIS. 1999. PMID: 10190279 Review.
Human collagenase-3 (MMP-13) is a matrix metalloproteinase originally identified in breast carcinomas. ...
Human collagenase-3 (MMP-13) is a matrix metalloproteinase originally identified in breast carcinomas. ...
E2 regulates MMP-13 via targeting miR-140 in IL-1beta-induced extracellular matrix degradation in human chondrocytes.
Liang Y, Duan L, Xiong J, Zhu W, Liu Q, Wang D, Liu W, Li Z, Wang D. Liang Y, et al. Arthritis Res Ther. 2016 May 10;18(1):105. doi: 10.1186/s13075-016-0997-y. Arthritis Res Ther. 2016. PMID: 27165343 Free PMC article.
This study aimed to determine the role of miR-140 in the estrogen-dependent regulation of MMP-13 in human chondrocytes. METHODS: Primary human articular chondrocytes were obtained from female OA patients undergoing knee replacement surgery. ...MMP
This study aimed to determine the role of miR-140 in the estrogen-dependent regulation of MMP-13 in human chondrocytes. …
RECK suppresses interleukin-17/TRAF3IP2-mediated MMP-13 activation and human aortic smooth muscle cell migration and proliferation.
Mummidi S, Das NA, Carpenter AJ, Yoshida T, Yariswamy M, Mostany R, Izadpanah R, Higashi Y, Sukhanov S, Noda M, Siebenlist U, Rector RS, Chandrasekar B. Mummidi S, et al. J Cell Physiol. 2019 Dec;234(12):22242-22259. doi: 10.1002/jcp.28792. Epub 2019 May 9. J Cell Physiol. 2019. PMID: 31074012 Free PMC article.
In fact, gain of TRAG3IP2 function, by itself, induced MMP-13 expression and activation, and RECK suppression. Furthermore, treatment with recombinant MMP-13 stimulated SMC migration in part via ERK activation. Importantly, RECK gain-of-function attenu …
In fact, gain of TRAG3IP2 function, by itself, induced MMP-13 expression and activation, and RECK suppression. Furthermore, tr …
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.
Yamamoto K, Okano H, Miyagawa W, Visse R, Shitomi Y, Santamaria S, Dudhia J, Troeberg L, Strickland DK, Hirohata S, Nagase H. Yamamoto K, et al. Matrix Biol. 2016 Dec;56:57-73. doi: 10.1016/j.matbio.2016.03.007. Epub 2016 Apr 12. Matrix Biol. 2016. PMID: 27084377 Free PMC article.
The wide range of MMP-13 proteolytic capacity suggests that it is a powerful, potentially destructive proteinase and thus it has been believed that MMP-13 is not produced in most adult human tissues in the steady state. ...MMP-13 i …
The wide range of MMP-13 proteolytic capacity suggests that it is a powerful, potentially destructive proteinase and thus it h …
Selective MMP-13 Inhibitors: Promising Agents for the Therapy of Osteoarthritis.
Wan Y, Li W, Liao Z, Yan M, Chen X, Tang Z. Wan Y, et al. Curr Med Chem. 2020;27(22):3753-3769. doi: 10.2174/0929867326666181217153118. Curr Med Chem. 2020. PMID: 30556497 Review.
It is noted that MMP-13 is specially expressed in the OA patients, and not in normal adults. ...In this review, we summarize the recent progress of selective MMP-13 inhibitors including two subfamilies, namely zinc-binding and non-zinc-binding selectiv …
It is noted that MMP-13 is specially expressed in the OA patients, and not in normal adults. ...In this review, we summarize t …
Mechanical forces-induced human osteoblasts differentiation involves MMP-2/MMP-13/MT1-MMP proteolytic cascade.
Barthelemi S, Robinet J, Garnotel R, Antonicelli F, Schittly E, Hornebeck W, Lorimier S. Barthelemi S, et al. J Cell Biochem. 2012 Mar;113(3):760-72. doi: 10.1002/jcb.23401. J Cell Biochem. 2012. PMID: 22006368
In this study, we have investigated the contribution of both proteolytic cascades, MMP-3/MMP-1 and MMP-2/MMP-13/MT1-MMP in the differentiation of human osteoblasts cultured in a floating type I collagen lattice (FL) versus an attached collagen lattice (AL). . …
In this study, we have investigated the contribution of both proteolytic cascades, MMP-3/MMP-1 and MMP-2/MMP-13/MT1-MMP in the …
2,564 results