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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1988 4
1989 2
1990 3
1991 1
1992 3
1993 4
1994 6
1995 5
1996 8
1997 8
1998 6
1999 2
2000 2
2001 5
2002 5
2003 23
2004 29
2005 24
2006 24
2007 19
2008 19
2009 15
2010 18
2011 16
2012 12
2013 12
2014 8
2015 7
2016 10
2017 7
2018 1
2019 6
2020 5
2021 3
2022 8
2023 4
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2025 7
2026 3

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321 results

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Page 1
Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, Wu J, Wei X, Qu Q, Yu Y, Long S, Feng JW, Li C, Zhang C, Xie C, Wu Y, Xu Z, Chen J, Yu Y, Huang X, He Y, Yao L, Zhang L, Zhu M, Wang W, Wang ZC, Zhang M, Bao Y, Jia W, Lin SY, Ye Z, Piao HL, Deng X, Zhang CS, Lin SC. Ma T, et al. Nature. 2022 Mar;603(7899):159-165. doi: 10.1038/s41586-022-04431-8. Epub 2022 Feb 23. Nature. 2022. PMID: 35197629 Free PMC article.
Knockout of PEN2 or re-introduction of a PEN2 mutant that does not bind ATP6AP1 blunts AMPK activation. In vivo, liver-specific knockout of Pen2 abolishes metformin-mediated reduction of hepatic fat content, whereas intestine-specific knockout of Pen2 …
Knockout of PEN2 or re-introduction of a PEN2 mutant that does not bind ATP6AP1 blunts AMPK activation. In vivo, liver-specifi …
γ-Secretase in Alzheimer's disease.
Hur JY. Hur JY. Exp Mol Med. 2022 Apr;54(4):433-446. doi: 10.1038/s12276-022-00754-8. Epub 2022 Apr 8. Exp Mol Med. 2022. PMID: 35396575 Free PMC article. Review.
Imeglimin ameliorates MASLD by targeting PEN2 to activate AMPK pathway.
Li J, Zhang R, Zeng X, Xu W, Gao L, He S, Wu B, Ma Y, Nie Y, Shirakawa J, Xia H, Li W. Li J, et al. Metabolism. 2026 Feb;175:156458. doi: 10.1016/j.metabol.2025.156458. Epub 2025 Nov 25. Metabolism. 2026. PMID: 41308829 Free article.
The therapeutic effects of imeglimin are abrogated in liver-specific Pen2-deficient mice or upon pharmacologic inhibition of AMP-activated protein kinase (AMPK), indicating that activation of PEN2-AMPK signaling is required for its beneficial effects. Furthermore, w …
The therapeutic effects of imeglimin are abrogated in liver-specific Pen2-deficient mice or upon pharmacologic inhibition of AMP-acti …
Uncovering gamma-secretase.
Steiner H. Steiner H. Curr Alzheimer Res. 2004 Aug;1(3):175-81. doi: 10.2174/1567205043332081. Curr Alzheimer Res. 2004. PMID: 15975065 Review.
Pen2/ErbB4 signaling regulates stemness of pancreatic ductal carcinoma.
Zhu Z, Ding D, Hu H, He T. Zhu Z, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Oct;1870(7):167316. doi: 10.1016/j.bbadis.2024.167316. Epub 2024 Jun 18. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38901650 Free article.
Pen2-positive cells were sorted from Pen2-negative ones in PDAC cells transduced with a vector designed to express green fluorescent protein (GFP) under the Pen2 promoter. ...Altering Pen2 levels reversed these oncogenic effects. In vivo, Pen2-p …
Pen2-positive cells were sorted from Pen2-negative ones in PDAC cells transduced with a vector designed to express green fluor …
Evaluation of PEN2-ATP6AP1 axis as an antiparasitic target for metformin based on phylogeny analysis and molecular docking.
Liu C, Zhang S, Xue J, Zhang H, Yin J. Liu C, et al. Mol Biochem Parasitol. 2023 Sep;255:111580. doi: 10.1016/j.molbiopara.2023.111580. Epub 2023 Jul 18. Mol Biochem Parasitol. 2023. PMID: 37473813
METHODS: To explore the possibility of PEN2-ATP6AP1 axis as a drug target of Met for the treatment of parasitic diseases, we identified and characterized orthologs of PEN2 and ATP6AP1 genes in parasites, by constructing phylogenetic trees, analyzing protein sequence …
METHODS: To explore the possibility of PEN2-ATP6AP1 axis as a drug target of Met for the treatment of parasitic diseases, we identifi …
Three-dimensional structure of human gamma-secretase.
Lu P, Bai XC, Ma D, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SHW, Shi Y. Lu P, et al. Nature. 2014 Aug 14;512(7513):166-170. doi: 10.1038/nature13567. Epub 2014 Jun 29. Nature. 2014. PMID: 25043039 Free PMC article.
Here we report the three-dimensional structure of an intact human gamma-secretase complex at 4.5 A resolution, determined by cryo-electron-microscopy single-particle analysis. ...
Here we report the three-dimensional structure of an intact human gamma-secretase complex at 4.5 A resolution, determined by cryo-ele …
General anesthetics and β-amyloid protein.
Xie Z, Xu Z. Xie Z, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 2;47:140-6. doi: 10.1016/j.pnpbp.2012.08.002. Epub 2012 Aug 14. Prog Neuropsychopharmacol Biol Psychiatry. 2013. PMID: 22918033 Free PMC article. Review.
Structural basis of human gamma-secretase assembly.
Sun L, Zhao L, Yang G, Yan C, Zhou R, Zhou X, Xie T, Zhao Y, Wu S, Li X, Shi Y. Sun L, et al. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6003-8. doi: 10.1073/pnas.1506242112. Epub 2015 Apr 27. Proc Natl Acad Sci U S A. 2015. PMID: 25918421 Free PMC article.
Despite recent structural advances, the transmembrane segments (TMs) of gamma-secretase remain to be specifically assigned. Here we report a 3D structure of human gamma-secretase at 4.32-A resolution, determined by single-particle, electron cryomicroscopy in the presence o …
Despite recent structural advances, the transmembrane segments (TMs) of gamma-secretase remain to be specifically assigned. Here we report a …
321 results