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Human telomerase reverse transcriptase regulation by DNA methylation, transcription factor binding and alternative splicing (Review).
Avin BA, Umbricht CB, Zeiger MA. Avin BA, et al. Int J Oncol. 2016 Dec;49(6):2199-2205. doi: 10.3892/ijo.2016.3743. Epub 2016 Oct 20. Int J Oncol. 2016. PMID: 27779655 Free PMC article. Review.
The catalytic subunit of telomerase, human telomerase reverse transcriptase (hTERT), plays an essential role in telomere maintenance to oppose cellular senescence and, is highly regulated in normal and cancerous cells. ...Promoter meth …
The catalytic subunit of telomerase, human telomerase reverse transcriptase (hTERT), plays an essential r …
Characterization of Allele-Specific Regulation of Telomerase Reverse Transcriptase in Promoter Mutant Thyroid Cancer Cell Lines.
McKelvey BA, Gilpatrick T, Wang Y, Timp W, Umbricht CB, Zeiger MA. McKelvey BA, et al. Thyroid. 2020 Oct;30(10):1470-1481. doi: 10.1089/thy.2020.0055. Epub 2020 May 4. Thyroid. 2020. PMID: 32228178 Free PMC article.
TERT promoter methylation, transcription factor binding, chromatin remodeling, and alternative splicing are also known to play an integral role in TERT regulation. ...Conclusions: In summary, by employing new long-read sequencing m …
TERT promoter methylation, transcription factor binding, chromatin remodeling, and alternative splicin …