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Page 1
Intratumoral dendritic cell-CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma.
Magen A, Hamon P, Fiaschi N, Soong BY, Park MD, Mattiuz R, Humblin E, Troncoso L, D'souza D, Dawson T, Kim J, Hamel S, Buckup M, Chang C, Tabachnikova A, Schwartz H, Malissen N, Lavin Y, Soares-Schanoski A, Giotti B, Hegde S, Ioannou G, Gonzalez-Kozlova E, Hennequin C, Le Berichel J, Zhao Z, Ward SC, Fiel I, Kou B, Dobosz M, Li L, Adler C, Ni M, Wei Y, Wang W, Atwal GS, Kundu K, Cygan KJ, Tsankov AM, Rahman A, Price C, Fernandez N, He J, Gupta NT, Kim-Schulze S, Gnjatic S, Kenigsberg E, Deering RP, Schwartz M, Marron TU, Thurston G, Kamphorst AO, Merad M. Magen A, et al. Among authors: humblin e. Nat Med. 2023 Jun;29(6):1389-1399. doi: 10.1038/s41591-023-02345-0. Epub 2023 Jun 15. Nat Med. 2023. PMID: 37322116 Free PMC article.
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer.
Park MD, Reyes-Torres I, LeBerichel J, Hamon P, LaMarche NM, Hegde S, Belabed M, Troncoso L, Grout JA, Magen A, Humblin E, Nair A, Molgora M, Hou J, Newman JH, Farkas AM, Leader AM, Dawson T, D'Souza D, Hamel S, Sanchez-Paulete AR, Maier B, Bhardwaj N, Martin JC, Kamphorst AO, Kenigsberg E, Casanova-Acebes M, Horowitz A, Brown BD, De Andrade LF, Colonna M, Marron TU, Merad M. Park MD, et al. Among authors: humblin e. Nat Immunol. 2023 May;24(5):792-801. doi: 10.1038/s41590-023-01475-4. Epub 2023 Apr 20. Nat Immunol. 2023. PMID: 37081148 Free PMC article.
Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1+ PD-1+ CD8 T cells.
Humblin E, Korpas I, Lu J, Filipescu D, van der Heide V, Goldstein S, Vaidya A, Soares-Schanoski A, Casati B, Selvan ME, Gümüş ZH, Wieland A, Corrado M, Cohen-Gould L, Bernstein E, Homann D, Chipuk J, Kamphorst AO. Humblin E, et al. Sci Immunol. 2023 Aug 4;8(86):eadg0878. doi: 10.1126/sciimmunol.adg0878. Epub 2023 Aug 25. Sci Immunol. 2023. PMID: 37624910 Free PMC article.
TH9 cells in anti-tumor immunity.
Rivera Vargas T, Humblin E, Végran F, Ghiringhelli F, Apetoh L. Rivera Vargas T, et al. Among authors: humblin e. Semin Immunopathol. 2017 Jan;39(1):39-46. doi: 10.1007/s00281-016-0599-4. Epub 2016 Nov 10. Semin Immunopathol. 2017. PMID: 27832300 Free PMC article. Review.
MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping.
Filipescu D, Carcamo S, Agarwal A, Tung N, Humblin É, Goldberg MS, Vyas NS, Beaumont KG, Demircioglu D, Sridhar S, Ghiraldini FG, Capparelli C, Aplin AE, Salmon H, Sebra R, Kamphorst AO, Merad M, Hasson D, Bernstein E. Filipescu D, et al. Among authors: humblin e. Nat Cell Biol. 2023 Sep;25(9):1332-1345. doi: 10.1038/s41556-023-01208-7. Epub 2023 Aug 21. Nat Cell Biol. 2023. PMID: 37605008 Free PMC article.
CXCR3-CXCL9: It's All in the Tumor.
Humblin E, Kamphorst AO. Humblin E, et al. Immunity. 2019 Jun 18;50(6):1347-1349. doi: 10.1016/j.immuni.2019.05.013. Immunity. 2019. PMID: 31216458 Free article.
Exhausted T cells never fully recover.
Reid A, Humblin E. Reid A, et al. Among authors: humblin e. Nat Rev Immunol. 2021 Jul;21(7):408. doi: 10.1038/s41577-021-00575-2. Nat Rev Immunol. 2021. PMID: 34103705 No abstract available.
Advancing beyond the twists and turns of T cell exhaustion in cancer.
van der Heide V, Humblin E, Vaidya A, Kamphorst AO. van der Heide V, et al. Among authors: humblin e. Sci Transl Med. 2022 Nov 9;14(670):eabo4997. doi: 10.1126/scitranslmed.abo4997. Epub 2022 Nov 9. Sci Transl Med. 2022. PMID: 36350991 Free PMC article. Review.
21 results