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Platelet and Plasma Phosphatidylcholines as Biomarkers to Diagnose Cerebral Amyloid Angiopathy.
Foidl BM, Oberacher H, Marksteiner J, Humpel C. Foidl BM, et al. Among authors: humpel c. Front Neurol. 2020 Jun 12;11:359. doi: 10.3389/fneur.2020.00359. eCollection 2020. Front Neurol. 2020. PMID: 32595581 Free PMC article.
The aim of the present study was to analyze different lipids [phosphatidylcholines (PCs) and lysoPCs] in platelets and plasma of a novel mouse model of sporadic CAA (1). Our data show that lipids are significantly altered in plasma of the CAA mice. ...Our data show …
The aim of the present study was to analyze different lipids [phosphatidylcholines (PCs) and lysoPCs] in platelets and plasma of a no …
Plasma phosphatidylcholines and vitamin B12/folate levels are possible prognostic biomarkers for progression of Alzheimer's disease.
Blasko I, Defrancesco M, Oberacher H, Loacker L, Kemmler G, Marksteiner J, Humpel C. Blasko I, et al. Among authors: humpel c. Exp Gerontol. 2021 May;147:111264. doi: 10.1016/j.exger.2021.111264. Epub 2021 Jan 28. Exp Gerontol. 2021. PMID: 33516907 Free article.
Blood was collected, various biochemical markers (including vitamin B12 and folate) analysed and plasma lipids were measured using the AbsoluteIDQ p150 Kit. RESULTS: There was no significant change in lipid levels in controls converting to MCI. ...CONCLUSIONS: Taken togeth …
Blood was collected, various biochemical markers (including vitamin B12 and folate) analysed and plasma lipids were measured using th …
Dose-related plasma levels of clozapine: influence of smoking behaviour, sex and age.
Haring C, Meise U, Humpel C, Saria A, Fleischhacker WW, Hinterhuber H. Haring C, et al. Among authors: humpel c. Psychopharmacology (Berl). 1989;99 Suppl:S38-40. doi: 10.1007/BF00442557. Psychopharmacology (Berl). 1989. PMID: 2813665
However, the average plasma concentration at a given dose was only 81.8% in smokers, compared to non-smokers. ...Dividing female patients into smokers and non-smokers, the smokers reached nearly the same plasma levels as the non-smokers. Male smoking patients reache …
However, the average plasma concentration at a given dose was only 81.8% in smokers, compared to non-smokers. ...Dividing female pati …
Dkk-3 is elevated in CSF and plasma of Alzheimer's disease patients.
Zenzmaier C, Marksteiner J, Kiefer A, Berger P, Humpel C. Zenzmaier C, et al. Among authors: humpel c. J Neurochem. 2009 Jul;110(2):653-61. doi: 10.1111/j.1471-4159.2009.06158.x. Epub 2009 May 11. J Neurochem. 2009. PMID: 19457090 Free PMC article.
Significantly increased Dkk-3 levels in plasma and CSF were observed for AD patients compared with healthy subjects but not patients suffering from MCI or depression. In summary, our data indicate that elevated Dkk-3 levels are specifically associated with AD and might ser …
Significantly increased Dkk-3 levels in plasma and CSF were observed for AD patients compared with healthy subjects but not patients …
Phospho-tau 181 is enhanced in saliva and plasma of edentulous patients: a first sign of dementia?
Zürcher C, Defrancesco M, Humpel C. Zürcher C, et al. Among authors: humpel c. Front Oral Health. 2025 Jul 30;6:1627681. doi: 10.3389/froh.2025.1627681. eCollection 2025. Front Oral Health. 2025. PMID: 40809956 Free PMC article.
Patients underwent a neuropsychological assessment, and plasma pTau181 was analyzed. RESULTS: No changes were seen for salivary beta-amyloid and total tau; however, salivary pTau181 was significantly increased in edentulous patients. This was accompanied by enhanced pla …
Patients underwent a neuropsychological assessment, and plasma pTau181 was analyzed. RESULTS: No changes were seen for salivary beta- …
Novel Plasma Biomarkers for Alzheimer's Disease: Insights from Organotypic Brain Slice and Microcontact Printing Techniques.
Yilmaz SN, Steiner K, Marksteiner J, Faserl K, Sarg B, Humpel C. Yilmaz SN, et al. Among authors: humpel c. Front Biosci (Landmark Ed). 2025 Mar 24;30(3):36257. doi: 10.31083/FBL36257. Front Biosci (Landmark Ed). 2025. PMID: 40152394 Free article.
We hypothesize that AD plasma contains factors that affect endothelial cell migration and new vessel formation. METHODS: In the present study, plasma from human patients is microcontact printed and connected to mouse brain slices. ...
We hypothesize that AD plasma contains factors that affect endothelial cell migration and new vessel formation. METHODS: In the prese …
From Organotypic Mouse Brain Slices to Human Alzheimer Plasma Biomarkers: A Focus on Microglia.
Steiner K, Yilmaz SN, Gern A, Marksteiner J, Faserl K, Villunger M, Sarg B, Humpel C. Steiner K, et al. Among authors: humpel c. Biomolecules. 2024 Sep 3;14(9):1109. doi: 10.3390/biom14091109. Biomolecules. 2024. PMID: 39334874 Free PMC article.
Our research focuses on identifying novel plasma biomarkers for Alzheimer's disease. To achieve this, we employed a technique that involves coupling human plasma to mouse organotypic brain slices via microcontact prints. After culturing for two weeks, we assessed Ib …
Our research focuses on identifying novel plasma biomarkers for Alzheimer's disease. To achieve this, we employed a technique that in …
Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer's disease.
Marksteiner J, Kemmler G, Weiss EM, Knaus G, Ullrich C, Mechtcheriakov S, Oberbauer H, Auffinger S, Hinterhölzl J, Hinterhuber H, Humpel C. Marksteiner J, et al. Among authors: humpel c. Neurobiol Aging. 2011 Mar;32(3):539-40. doi: 10.1016/j.neurobiolaging.2009.03.011. Epub 2009 Apr 22. Neurobiol Aging. 2011. PMID: 19395124 Free PMC article.
Quantitative analysis revealed an increased concentration in Biocoll isolated plasma of 5 out of these 16 proteins in MCI and AD patients compared to healthy subjects: EGF, GDNF and MIP1delta (in AD), MIP4 (in MCI) and RANTES (in MCI and AD). ...However, the overall expres …
Quantitative analysis revealed an increased concentration in Biocoll isolated plasma of 5 out of these 16 proteins in MCI and AD pati …
From Organotypic Mouse Brain Slices to Human Alzheimer's Plasma Biomarkers: A Focus on Nerve Fiber Outgrowth.
Yilmaz SN, Steiner K, Marksteiner J, Faserl K, Villunger M, Sarg B, Humpel C. Yilmaz SN, et al. Among authors: humpel c. Biomolecules. 2024 Oct 18;14(10):1326. doi: 10.3390/biom14101326. Biomolecules. 2024. PMID: 39456259 Free PMC article.
Being able to identify reliable biomarkers in easily available body fluids such as blood plasma is vital for the disease. To achieve this, we used a technique that applied human plasma to organotypic brain slice culture via microcontact printing. ...According to our …
Being able to identify reliable biomarkers in easily available body fluids such as blood plasma is vital for the disease. To achieve …
25 results