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DNA double-strand break repair pathways, chromosomal rearrangements and cancer.
Kasparek TR, Humphrey TC. Kasparek TR, et al. Semin Cell Dev Biol. 2011 Oct;22(8):886-97. doi: 10.1016/j.semcdb.2011.10.007. Epub 2011 Oct 17. Semin Cell Dev Biol. 2011. PMID: 22027614 Review.
An essential role for dNTP homeostasis following CDK-induced replication stress.
Pai CC, Hsu KF, Durley SC, Keszthelyi A, Kearsey SE, Rallis C, Folkes LK, Deegan R, Wilkins SE, Pfister SX, De León N, Schofield CJ, Bähler J, Carr AM, Humphrey TC. Pai CC, et al. Among authors: humphrey tc. J Cell Sci. 2019 Mar 25;132(6):jcs226969. doi: 10.1242/jcs.226969. J Cell Sci. 2019. PMID: 30674555 Free PMC article.
Nucleoporin 54 contributes to homologous recombination repair and post-replicative DNA integrity.
Rodriguez-Berriguete G, Granata G, Puliyadi R, Tiwana G, Prevo R, Wilson RS, Yu S, Buffa F, Humphrey TC, McKenna WG, Higgins GS. Rodriguez-Berriguete G, et al. Among authors: humphrey tc. Nucleic Acids Res. 2018 Sep 6;46(15):7731-7746. doi: 10.1093/nar/gky569. Nucleic Acids Res. 2018. PMID: 29986057 Free PMC article.
DNA Double-Strand Break Repair Assay.
Pai CC, Blaikley E, Humphrey TC. Pai CC, et al. Among authors: humphrey tc. Cold Spring Harb Protoc. 2018 Apr 2;2018(4). doi: 10.1101/pdb.prot092031. Cold Spring Harb Protoc. 2018. PMID: 28733408
Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.
Pai CC, Kishkevich A, Deegan RS, Keszthelyi A, Folkes L, Kearsey SE, De León N, Soriano I, de Bruin RAM, Carr AM, Humphrey TC. Pai CC, et al. Among authors: humphrey tc. Cell Rep. 2017 Sep 12;20(11):2693-2705. doi: 10.1016/j.celrep.2017.08.058. Cell Rep. 2017. PMID: 28903048 Free PMC article.
MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress.
Bleuyard JY, Fournier M, Nakato R, Couturier AM, Katou Y, Ralf C, Hester SS, Dominguez D, Rhodes D, Humphrey TC, Shirahige K, Esashi F. Bleuyard JY, et al. Among authors: humphrey tc. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7671-7676. doi: 10.1073/pnas.1620208114. Epub 2017 Jul 3. Proc Natl Acad Sci U S A. 2017. PMID: 28673974 Free PMC article.
A role for human homologous recombination factors in suppressing microhomology-mediated end joining.
Ahrabi S, Sarkar S, Pfister SX, Pirovano G, Higgins GS, Porter AC, Humphrey TC. Ahrabi S, et al. Among authors: humphrey tc. Nucleic Acids Res. 2016 Jul 8;44(12):5743-57. doi: 10.1093/nar/gkw326. Epub 2016 Apr 29. Nucleic Acids Res. 2016. PMID: 27131361 Free PMC article.
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Pfister SX, Markkanen E, Jiang Y, Sarkar S, Woodcock M, Orlando G, Mavrommati I, Pai CC, Zalmas LP, Drobnitzky N, Dianov GL, Verrill C, Macaulay VM, Ying S, La Thangue NB, D'Angiolella V, Ryan AJ, Humphrey TC. Pfister SX, et al. Cancer Cell. 2015 Nov 9;28(5):557-568. doi: 10.1016/j.ccell.2015.09.015. Cancer Cell. 2015. PMID: 26602815 Free PMC article.
Use of the HPRT gene to study nuclease-induced DNA double-strand break repair.
Gravells P, Ahrabi S, Vangala RK, Tomita K, Brash JT, Brustle LA, Chung C, Hong JM, Kaloudi A, Humphrey TC, Porter AC. Gravells P, et al. Hum Mol Genet. 2015 Dec 15;24(24):7097-110. doi: 10.1093/hmg/ddv409. Epub 2015 Sep 30. Hum Mol Genet. 2015. PMID: 26423459 Free PMC article.
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