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Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope.
Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. Neumann-Haefelin C, et al. Among authors: humphreys i. Hepatology. 2010 Jan;51(1):54-62. doi: 10.1002/hep.23275. Hepatology. 2010. PMID: 20034048 Free PMC article.
Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure.
Rauch A, James I, Pfafferott K, Nolan D, Klenerman P, Cheng W, Mollison L, McCaughan G, Shackel N, Jeffrey GP, Baker R, Freitas E, Humphreys I, Furrer H, Günthard HF, Hirschel B, Mallal S, John M, Lucas M, Barnes E, Gaudieri S. Rauch A, et al. Among authors: humphreys i. Hepatology. 2009 Oct;50(4):1017-29. doi: 10.1002/hep.23101. Hepatology. 2009. PMID: 19670417
Global distribution and prevalence of hepatitis C virus genotypes.
Messina JP, Humphreys I, Flaxman A, Brown A, Cooke GS, Pybus OG, Barnes E. Messina JP, et al. Among authors: humphreys i. Hepatology. 2015 Jan;61(1):77-87. doi: 10.1002/hep.27259. Epub 2014 Jul 28. Hepatology. 2015. PMID: 25069599 Free PMC article.
Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy.
Gaudieri S, Rauch A, Pfafferott K, Barnes E, Cheng W, McCaughan G, Shackel N, Jeffrey GP, Mollison L, Baker R, Furrer H, Günthard HF, Freitas E, Humphreys I, Klenerman P, Mallal S, James I, Roberts S, Nolan D, Lucas M. Gaudieri S, et al. Among authors: humphreys i. Hepatology. 2009 Apr;49(4):1069-82. doi: 10.1002/hep.22773. Hepatology. 2009. PMID: 19263475
Full-length characterization of hepatitis C virus subtype 3a reveals novel hypervariable regions under positive selection during acute infection.
Humphreys I, Fleming V, Fabris P, Parker J, Schulenberg B, Brown A, Demetriou C, Gaudieri S, Pfafferott K, Lucas M, Collier J, Huang KH, Pybus OG, Klenerman P, Barnes E. Humphreys I, et al. J Virol. 2009 Nov;83(22):11456-66. doi: 10.1128/JVI.00884-09. Epub 2009 Sep 9. J Virol. 2009. PMID: 19740991 Free PMC article.
Genetic history of hepatitis C virus in East Asia.
Pybus OG, Barnes E, Taggart R, Lemey P, Markov PV, Rasachak B, Syhavong B, Phetsouvanah R, Sheridan I, Humphreys IS, Lu L, Newton PN, Klenerman P. Pybus OG, et al. Among authors: humphreys is. J Virol. 2009 Jan;83(2):1071-82. doi: 10.1128/JVI.01501-08. Epub 2008 Oct 29. J Virol. 2009. PMID: 18971279 Free PMC article.
Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.
Farquhar MJ, Humphreys IS, Rudge SA, Wilson GK, Bhattacharya B, Ciaccia M, Hu K, Zhang Q, Mailly L, Reynolds GM, Ashcroft M, Balfe P, Baumert TF, Roessler S, Wakelam MJO, McKeating JA. Farquhar MJ, et al. J Hepatol. 2017 May;66(5):919-929. doi: 10.1016/j.jhep.2017.01.009. Epub 2017 Jan 23. J Hepatol. 2017. PMID: 28126468 Free article.
186 results