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Colonic crypt organization and tumorigenesis.
Humphries A, Wright NA. Humphries A, et al. Nat Rev Cancer. 2008 Jun;8(6):415-24. doi: 10.1038/nrc2392. Epub 2008 May 15. Nat Rev Cancer. 2008. PMID: 18480839 Review.
Quantification of crypt and stem cell evolution in the normal and neoplastic human colon.
Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G, McDonald SA, Wright NA, Simons BD, Jansen M, Graham TA. Baker AM, et al. Cell Rep. 2014 Aug 21;8(4):940-7. doi: 10.1016/j.celrep.2014.07.019. Epub 2014 Aug 7. Cell Rep. 2014. PMID: 25127143 Free PMC article.
Furthermore, we show that, in adenomatous crypts (APC(-/-)), there is a proportionate increase in both functional stem cell number and the loss/replacement rate. Finally, by analyzing fields of mtDNA mutant crypts, we show that a normal colon crypt divides around on …
Furthermore, we show that, in adenomatous crypts (APC(-/-)), there is a proportionate increase in both functional stem cell number an …
Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.
Humphries A, Cereser B, Gay LJ, Miller DS, Das B, Gutteridge A, Elia G, Nye E, Jeffery R, Poulsom R, Novelli MR, Rodriguez-Justo M, McDonald SA, Wright NA, Graham TA. Humphries A, et al. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2490-9. doi: 10.1073/pnas.1220353110. Epub 2013 Jun 13. Proc Natl Acad Sci U S A. 2013. PMID: 23766371 Free PMC article.
Numerous individual crypts from six colonic adenomas and a hyperplastic polyp were microdissected and characterized for genetic lesions. ...Topographical maps of clone locations were constructed using a combination of these data. Multilineage differentiation within …
Numerous individual crypts from six colonic adenomas and a hyperplastic polyp were microdissected and characterized for genetic lesio …
Stem cells and inflammation in the intestine.
Humphries A, Graham TA, McDonald SA. Humphries A, et al. Recent Results Cancer Res. 2011;185:51-63. doi: 10.1007/978-3-642-03503-6_3. Recent Results Cancer Res. 2011. PMID: 21822819 Review.
However, there is a scarcity of meaningful work within their human counterpart. Nevertheless, recent studies have demonstrated the processes of niche succession, where one stem cell takes over the entire population of stem cells within a crypt; and monoclonal conver …
However, there is a scarcity of meaningful work within their human counterpart. Nevertheless, recent studies have demonstrated the pr …
Use of methylation patterns to determine expansion of stem cell clones in human colon tissue.
Graham TA, Humphries A, Sanders T, Rodriguez-Justo M, Tadrous PJ, Preston SL, Novelli MR, Leedham SJ, McDonald SA, Wright NA. Graham TA, et al. Gastroenterology. 2011 Apr;140(4):1241-1250.e1-9. doi: 10.1053/j.gastro.2010.12.036. Epub 2010 Dec 28. Gastroenterology. 2011. PMID: 21192938
BACKGROUND & AIMS: It is a challenge to determine the dynamics of stem cells within human epithelial tissues such as colonic crypts. ...We developed a technique to follow changes in intestinal stem cell dynamics in human epithelial tissues that might be used to …
BACKGROUND & AIMS: It is a challenge to determine the dynamics of stem cells within human epithelial tissues such as colonic cryp …
Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor.
Nicholson AM, Graham TA, Simpson A, Humphries A, Burch N, Rodriguez-Justo M, Novelli M, Harrison R, Wright NA, McDonald SA, Jankowski JA. Nicholson AM, et al. Gut. 2012 Oct;61(10):1380-9. doi: 10.1136/gutjnl-2011-301174. Epub 2011 Dec 26. Gut. 2012. PMID: 22200839
In one patient, both the regenerating squamous epithelium and the underlying glandular tissue shared a clonal mutation, indicating that they are derived from a common progenitor cell. ...Furthermore, a single cell of origin can give rise to both squamous and …
In one patient, both the regenerating squamous epithelium and the underlying glandular tissue shared a clonal mutation, indicating th …
A methodological approach to tracing cell lineage in human epithelial tissues.
Fellous TG, McDonald SA, Burkert J, Humphries A, Islam S, De-Alwis NM, Gutierrez-Gonzalez L, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, El-Bahrawy M, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Day CP, Wright NA, Alison MR. Fellous TG, et al. Stem Cells. 2009 Jun;27(6):1410-20. doi: 10.1002/stem.67. Stem Cells. 2009. PMID: 19489031
We describe a technique for detecting the expansion of a single cell's progeny that contain clonal mitochondrial DNA (mtDNA) mutations affecting the expression of mtDNA-encoded cytochrome c oxidase (COX). ...In the skin, the origin of a basal cell carcinoma a …
We describe a technique for detecting the expansion of a single cell's progeny that contain clonal mitochondrial DNA (mtDNA) m …
Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study.
Choi CR, Al Bakir I, Ding NJ, Lee GH, Askari A, Warusavitarne J, Moorghen M, Humphries A, Ignjatovic-Wilson A, Thomas-Gibson S, Saunders BP, Rutter MD, Graham TA, Hart AL. Choi CR, et al. Gut. 2019 Mar;68(3):414-422. doi: 10.1136/gutjnl-2017-314190. Epub 2017 Nov 17. Gut. 2019. PMID: 29150489 Free PMC article.
DESIGN: This was a retrospective single-centre study. Patients with extensive UC who were under colonoscopic surveillance between 2003 and 2012 were studied. Each surveillance episode was scored for a severity of microscopic inflammation (0=no activity; 1=mild; 2=mo …
DESIGN: This was a retrospective single-centre study. Patients with extensive UC who were under colonoscopic surveillance between 200 …
Diagnosis and management of acute lower gastrointestinal bleeding: guidelines from the British Society of Gastroenterology.
Oakland K, Chadwick G, East JE, Guy R, Humphries A, Jairath V, McPherson S, Metzner M, Morris AJ, Murphy MF, Tham T, Uberoi R, Veitch AM, Wheeler J, Regan C, Hoare J. Oakland K, et al. Gut. 2019 May;68(5):776-789. doi: 10.1136/gutjnl-2018-317807. Epub 2019 Feb 12. Gut. 2019. PMID: 30792244
The Guidelines Development Group consisted of representatives from the BSG Endoscopy Committee, the Association of Coloproctology of Great Britain and Ireland, the British Society of Interventional Radiology, the Royal College of Radiologists, NHS Blood and Transplant and a
The Guidelines Development Group consisted of representatives from the BSG Endoscopy Committee, the Association of Coloproctology of Great B …
The histogenesis of regenerative nodules in human liver cirrhosis.
Lin WR, Lim SN, McDonald SA, Graham T, Wright VL, Peplow CL, Humphries A, Kocher HM, Wright NA, Dhillon AP, Alison MR. Lin WR, et al. Hepatology. 2010 Mar;51(3):1017-26. doi: 10.1002/hep.23483. Hepatology. 2010. PMID: 20198634
In all cases except for one, the nodules were monoclonal in nature, possessing up to four common mutations in all hepatocytes in a given nodule. ...CONCLUSION: These data support a novel pathway for the monoclonal derivation of human cirrhotic regenerative nodules f …
In all cases except for one, the nodules were monoclonal in nature, possessing up to four common mutations in all hepatocytes in a gi …
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