Huntington JA - Search Results

1

Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.

Skinner R, Chang WS, Jin L, Pei X, Huntington JA, Abrahams JP, Carrell RW, Lomas DA. Skinner R, et al. Among authors: huntington ja. J Mol Biol. 1998;283(1):9-14. doi: 10.1006/jmbi.1998.2083. J Mol Biol. 1998. PMID: 9761669

2

Helix D elongation and allosteric activation of antithrombin.

Belzar KJ, Zhou A, Carrell RW, Gettins PG, Huntington JA. Belzar KJ, et al. Among authors: huntington ja. J Biol Chem. 2002 Mar 8;277(10):8551-8. doi: 10.1074/jbc.M110807200. Epub 2001 Dec 10. J Biol Chem. 2002. PMID: 11741963 Free article.

3

How small peptides block and reverse serpin polymerisation.

Zhou A, Stein PE, Huntington JA, Sivasothy P, Lomas DA, Carrell RW. Zhou A, et al. Among authors: huntington ja. J Mol Biol. 2004 Sep 17;342(3):931-41. doi: 10.1016/j.jmb.2004.07.078. J Mol Biol. 2004. PMID: 15342247

4

The effect of a reducing-end extension on pentasaccharide binding by antithrombin.

Belzar KJ, Dafforn TR, Petitou M, Carrell RW, Huntington JA. Belzar KJ, et al. Among authors: huntington ja. J Biol Chem. 2000 Mar 24;275(12):8733-41. doi: 10.1074/jbc.275.12.8733. J Biol Chem. 2000. PMID: 10722716 Free article.

5

The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions.

Huntington JA, McCoy A, Belzar KJ, Pei XY, Gettins PG, Carrell RW. Huntington JA, et al. J Biol Chem. 2000 May 19;275(20):15377-83. doi: 10.1074/jbc.275.20.15377. J Biol Chem. 2000. PMID: 10809774 Free article.

6

Structure of a serpin-protease complex shows inhibition by deformation.

Huntington JA, Read RJ, Carrell RW. Huntington JA, et al. Nature. 2000 Oct 19;407(6806):923-6. doi: 10.1038/35038119. Nature. 2000. PMID: 11057674

7

A 2.6 A structure of a serpin polymer and implications for conformational disease.

Huntington JA, Pannu NS, Hazes B, Read RJ, Lomas DA, Carrell RW. Huntington JA, et al. J Mol Biol. 1999 Oct 29;293(3):449-55. doi: 10.1006/jmbi.1999.3184. J Mol Biol. 1999. PMID: 10543942

8

Formation of the antithrombin heterodimer in vivo and the onset of thrombosis.

Zhou A, Huntington JA, Carrell RW. Zhou A, et al. Among authors: huntington ja. Blood. 1999 Nov 15;94(10):3388-96. Blood. 1999. PMID: 10552948 Free article.

9

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.

Baglin TP, Carrell RW, Church FC, Esmon CT, Huntington JA. Baglin TP, et al. Among authors: huntington ja. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11079-84. doi: 10.1073/pnas.162232399. Epub 2002 Aug 8. Proc Natl Acad Sci U S A. 2002. PMID: 12169660 Free PMC article.

10

Antithrombin 'DREUX' (Lys 114Glu): a variant with complete loss of heparin affinity.

Mushunje A, Zhou A, Huntington JA, Conard J, Carrell RW. Mushunje A, et al. Among authors: huntington ja. Thromb Haemost. 2002 Sep;88(3):436-43. Thromb Haemost. 2002. PMID: 12353073

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