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Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity.
Ou O, Huppi K, Chakka S, Gehlhaus K, Dubois W, Patel J, Chen J, Mackiewicz M, Jones TL, Pitt JJ, Martin SE, Goldsmith P, Simmons JK, Mock BA, Caplen NJ. Ou O, et al. Among authors: huppi k. Cancer Lett. 2014 Nov 28;354(2):336-47. doi: 10.1016/j.canlet.2014.08.043. Epub 2014 Sep 1. Cancer Lett. 2014. PMID: 25193464 Free PMC article.
Defining and assaying RNAi in mammalian cells.
Huppi K, Martin SE, Caplen NJ. Huppi K, et al. Mol Cell. 2005 Jan 7;17(1):1-10. doi: 10.1016/j.molcel.2004.12.017. Mol Cell. 2005. PMID: 15629712 Free article. Review.
MicroRNAs and genomic instability.
Huppi K, Volfovsky N, Mackiewicz M, Runfola T, Jones TL, Martin SE, Stephens R, Caplen NJ. Huppi K, et al. Semin Cancer Biol. 2007 Feb;17(1):65-73. doi: 10.1016/j.semcancer.2006.10.004. Epub 2006 Oct 26. Semin Cancer Biol. 2007. PMID: 17113784 Free PMC article. Review.
Multiplexing siRNAs to compress RNAi-based screen size in human cells.
Martin SE, Jones TL, Thomas CL, Lorenzi PL, Nguyen DA, Runfola T, Gunsior M, Weinstein JN, Goldsmith PK, Lader E, Huppi K, Caplen NJ. Martin SE, et al. Among authors: huppi k. Nucleic Acids Res. 2007;35(8):e57. doi: 10.1093/nar/gkm141. Epub 2007 Mar 28. Nucleic Acids Res. 2007. PMID: 17392344 Free PMC article.
Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.
Hummon AB, Pitt JJ, Camps J, Emons G, Skube SB, Huppi K, Jones TL, Beissbarth T, Kramer F, Grade M, Difilippantonio MJ, Ried T, Caplen NJ. Hummon AB, et al. Among authors: huppi k. Mol Cancer. 2012 Jan 4;11:1. doi: 10.1186/1476-4598-11-1. Mol Cancer. 2012. PMID: 22216762 Free PMC article.
Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma.
Grohar PJ, Kim S, Rangel Rivera GO, Sen N, Haddock S, Harlow ML, Maloney NK, Zhu J, O'Neill M, Jones TL, Huppi K, Grandin M, Gehlhaus K, Klumpp-Thomas CA, Buehler E, Helman LJ, Martin SE, Caplen NJ. Grohar PJ, et al. Among authors: huppi k. Cell Rep. 2016 Jan 26;14(3):598-610. doi: 10.1016/j.celrep.2015.12.063. Epub 2016 Jan 14. Cell Rep. 2016. PMID: 26776507 Free PMC article.
Genomic instability and mouse microRNAs.
Huppi K, Pitt J, Wahlberg B, Caplen NJ. Huppi K, et al. Toxicol Mech Methods. 2011 May;21(4):325-33. doi: 10.3109/15376516.2011.562759. Toxicol Mech Methods. 2011. PMID: 21495870 Free PMC article. Review.
119 results