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Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer.
Riesenberg BP, Hunt EG, Tennant MD, Hurst KE, Andrews AM, Leddy LR, Neskey DM, Hill EG, Rivera GOR, Paulos CM, Gao P, Thaxton JE. Riesenberg BP, et al. Among authors: hurst ke. Cancer Res. 2022 Dec 2;82(23):4386-4399. doi: 10.1158/0008-5472.CAN-22-1744. Cancer Res. 2022. PMID: 36126165 Free PMC article.
Remodeling Translation Primes CD8+ T-cell Antitumor Immunity.
Hurst KE, Lawrence KA, Robino RA, Ball LE, Chung D, Thaxton JE. Hurst KE, et al. Cancer Immunol Res. 2020 May;8(5):587-595. doi: 10.1158/2326-6066.CIR-19-0516. Epub 2020 Feb 19. Cancer Immunol Res. 2020. PMID: 32075802 Free PMC article.
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.
Mehta AK, Cheney EM, Hartl CA, Pantelidou C, Oliwa M, Castrillon JA, Lin JR, Hurst KE, de Oliveira Taveira M, Johnson NT, Oldham WM, Kalocsay M, Berberich MJ, Boswell SA, Kothari A, Johnson S, Dillon DA, Lipschitz M, Rodig S, Santagata S, Garber JE, Tung N, Yélamos J, Thaxton JE, Mittendorf EA, Sorger PK, Shapiro GI, Guerriero JL. Mehta AK, et al. Among authors: hurst ke. Nat Cancer. 2021 Jan;2(1):66-82. doi: 10.1038/s43018-020-00148-7. Epub 2020 Dec 14. Nat Cancer. 2021. PMID: 33738458 Free PMC article.
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
Alicea Pauneto CDM, Riesenberg BP, Gandy EJ, Kennedy AS, Clutton GT, Hem JW, Hurst KE, Hunt EG, Green JM, Miller BC, Angus SP, Johnson GL, Esther RJ, Guerriero JL, Gao P, Soto-Pantoja DR, Ferris RL, Modliszewski JL, Coleman MF, Chung HK, Milner JJ, Moschos SJ, Wiseman RL, Thaxton JE. Alicea Pauneto CDM, et al. Among authors: hurst ke. Immunity. 2025 Oct 14;58(10):2489-2504.e8. doi: 10.1016/j.immuni.2025.09.003. Epub 2025 Sep 25. Immunity. 2025. PMID: 41005293 Free article.
22 results