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Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2).
Machwate M, Harada S, Leu CT, Seedor G, Labelle M, Gallant M, Hutchins S, Lachance N, Sawyer N, Slipetz D, Metters KM, Rodan SB, Young R, Rodan GA. Machwate M, et al. Among authors: hutchins s. Mol Pharmacol. 2001 Jul;60(1):36-41. doi: 10.1124/mol.60.1.36. Mol Pharmacol. 2001. PMID: 11408598
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM. Rohrer SP, et al. Among authors: hutchins sm. Science. 1998 Oct 23;282(5389):737-40. doi: 10.1126/science.282.5389.737. Science. 1998. PMID: 9784130
Combinatorial synthesis of 3-(amidoalkyl) and 3-(aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors.
Willoughby CA, Hutchins SM, Rosauer KG, Dhar MJ, Chapman KT, Chicchi GG, Sadowski S, Weinberg DH, Patel S, Malkowitz L, Di Salvo J, Pacholok SG, Cheng K. Willoughby CA, et al. Among authors: hutchins sm. Bioorg Med Chem Lett. 2002 Jan 7;12(1):93-6. doi: 10.1016/s0960-894x(01)00665-5. Bioorg Med Chem Lett. 2002. PMID: 11738581
Dendrimer-supported combinatorial chemistry.
Kim RM, Manna M, Hutchins SM, Griffin PR, Yates NA, Bernick AM, Chapman KT. Kim RM, et al. Among authors: hutchins sm. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10012-7. doi: 10.1073/pnas.93.19.10012. Proc Natl Acad Sci U S A. 1996. PMID: 11607705 Free PMC article.
Somatostatin receptor subtypes 2 and 5 mediate inhibition of egg yolk-induced gall bladder emptying in mice.
Kaczmarek P, Singh V, Cashen DE, Yang L, Berk S, Pasternak A, Xiong Y, Shen DM, Hutchins SM, Chapman K, Wiedenmann B, Schaeffer JM, Strowski MZ. Kaczmarek P, et al. Among authors: hutchins sm. Neurogastroenterol Motil. 2010 Feb;22(2):204-9, e66. doi: 10.1111/j.1365-2982.2009.01407.x. Epub 2009 Sep 15. Neurogastroenterol Motil. 2010. PMID: 19754922
211 results