Hutchinson K - Search Results

1

BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors.

Dahlman KB, Xia J, Hutchinson K, Ng C, Hucks D, Jia P, Atefi M, Su Z, Branch S, Lyle PL, Hicks DJ, Bozon V, Glaspy JA, Rosen N, Solit DB, Netterville JL, Vnencak-Jones CL, Sosman JA, Ribas A, Zhao Z, Pao W. Dahlman KB, et al. Among authors: hutchinson k. Cancer Discov. 2012 Sep;2(9):791-7. doi: 10.1158/2159-8290.CD-12-0097. Epub 2012 Jul 13. Cancer Discov. 2012. PMID: 22798288 Free PMC article.

2

Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer.

Chmielecki J, Peifer M, Jia P, Socci ND, Hutchinson K, Viale A, Zhao Z, Thomas RK, Pao W. Chmielecki J, et al. Among authors: hutchinson k. Nucleic Acids Res. 2010 Nov;38(20):6985-96. doi: 10.1093/nar/gkq579. Epub 2010 Jun 29. Nucleic Acids Res. 2010. PMID: 20587502 Free PMC article.

3

A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer.

Su Z, Dias-Santagata D, Duke M, Hutchinson K, Lin YL, Borger DR, Chung CH, Massion PP, Vnencak-Jones CL, Iafrate AJ, Pao W. Su Z, et al. Among authors: hutchinson k. J Mol Diagn. 2011 Jan;13(1):74-84. doi: 10.1016/j.jmoldx.2010.11.010. Epub 2010 Dec 23. J Mol Diagn. 2011. PMID: 21227397 Free PMC article.

4

EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib.

Chmielecki J, Pietanza MC, Aftab D, Shen R, Zhao Z, Chen X, Hutchinson K, Viale A, Kris MG, Stout T, Miller V, Rizvi N, Pao W. Chmielecki J, et al. Among authors: hutchinson k. J Thorac Oncol. 2012 Feb;7(2):434-42. doi: 10.1097/JTO.0b013e31823c5aee. J Thorac Oncol. 2012. PMID: 22173702 Free PMC article.

5

Chipping away at the lung cancer genome.

Pao W, Hutchinson KE. Pao W, et al. Nat Med. 2012 Mar 6;18(3):349-51. doi: 10.1038/nm.2697. Nat Med. 2012. PMID: 22395697 No abstract available.

6

BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition.

Hutchinson KE, Lipson D, Stephens PJ, Otto G, Lehmann BD, Lyle PL, Vnencak-Jones CL, Ross JS, Pietenpol JA, Sosman JA, Puzanov I, Miller VA, Pao W. Hutchinson KE, et al. Clin Cancer Res. 2013 Dec 15;19(24):6696-702. doi: 10.1158/1078-0432.CCR-13-1746. Clin Cancer Res. 2013. PMID: 24345920 Free PMC article.

7

A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance.

Xia J, Jia P, Hutchinson KE, Dahlman KB, Johnson D, Sosman J, Pao W, Zhao Z. Xia J, et al. Mol Cancer Ther. 2014 Jul;13(7):1918-28. doi: 10.1158/1535-7163.MCT-13-0804. Epub 2014 Apr 22. Mol Cancer Ther. 2014. PMID: 24755198 Free PMC article.

8

Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes.

Chmielecki J, Hutchinson KE, Frampton GM, Chalmers ZR, Johnson A, Shi C, Elvin J, Ali SM, Ross JS, Basturk O, Balasubramanian S, Lipson D, Yelensky R, Pao W, Miller VA, Klimstra DS, Stephens PJ. Chmielecki J, et al. Cancer Discov. 2014 Dec;4(12):1398-405. doi: 10.1158/2159-8290.CD-14-0617. Epub 2014 Sep 29. Cancer Discov. 2014. PMID: 25266736

9

MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis.

Jia P, Wang Q, Chen Q, Hutchinson KE, Pao W, Zhao Z. Jia P, et al. Genome Biol. 2014;15(10):489. doi: 10.1186/s13059-014-0489-9. Genome Biol. 2014. PMID: 25348067 Free PMC article.

10

Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer.

Meador CB, Jin H, de Stanchina E, Nebhan CA, Pirazzoli V, Wang L, Lu P, Vuong H, Hutchinson KE, Jia P, Chen X, Eisenberg R, Ladanyi M, Politi K, Zhao Z, Lovly CM, Cross DA, Pao W. Meador CB, et al. Among authors: hutchinson ke. Mol Cancer Ther. 2015 Feb;14(2):542-52. doi: 10.1158/1535-7163.MCT-14-0723. Epub 2014 Dec 4. Mol Cancer Ther. 2015. PMID: 25477325 Free PMC article.

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