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P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways.
Huynh N, Liu KH, Baldwin GS, He H. Huynh N, et al. Biochim Biophys Acta. 2010 Sep;1803(9):1106-13. doi: 10.1016/j.bbamcr.2010.05.007. Epub 2010 Jun 1. Biochim Biophys Acta. 2010. PMID: 20595063
P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth.
He H, Huynh N, Liu KH, Malcontenti-Wilson C, Zhu J, Christophi C, Shulkes A, Baldwin GS. He H, et al. Among authors: huynh n. Cancer Lett. 2012 Apr 1;317(1):65-71. doi: 10.1016/j.canlet.2011.11.014. Epub 2011 Nov 15. Cancer Lett. 2012. PMID: 22100495
p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.
Huynh N, Yim M, Chernoff J, Shulkes A, Baldwin GS, He H. Huynh N, et al. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15;304(6):G561-7. doi: 10.1152/ajpgi.00218.2012. Epub 2013 Jan 10. Am J Physiol Gastrointest Liver Physiol. 2013. PMID: 23306081 Free PMC article.
P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α.
Liu KH, Huynh N, Patel O, Shulkes A, Baldwin G, He H. Liu KH, et al. Among authors: huynh n. Cancer Lett. 2013 Oct 28;340(1):22-9. doi: 10.1016/j.canlet.2013.06.024. Epub 2013 Jun 26. Cancer Lett. 2013. PMID: 23811286
Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases.
Yeo D, Huynh N, Beutler JA, Christophi C, Shulkes A, Baldwin GS, Nikfarjam M, He H. Yeo D, et al. Among authors: huynh n. Cancer Lett. 2014 May 1;346(2):264-72. doi: 10.1016/j.canlet.2014.01.001. Epub 2014 Jan 31. Cancer Lett. 2014. PMID: 24491405 Free PMC article.
Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells.
Huynh N, Liu KH, Yim M, Shulkes A, Baldwin GS, He H. Huynh N, et al. Physiol Rep. 2014 Jun 24;2(6):e12048. doi: 10.14814/phy2.12048. Print 2014 Jun 1. Physiol Rep. 2014. PMID: 24963032 Free PMC article.
Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway.
Huynh N, Beutler JA, Shulkes A, Baldwin GS, He H. Huynh N, et al. Biochim Biophys Acta. 2015 Jan;1853(1):157-65. doi: 10.1016/j.bbamcr.2014.10.013. Epub 2014 Oct 22. Biochim Biophys Acta. 2015. PMID: 25409929
Glaucarubinone Combined with Gemcitabine Improves Pancreatic Cancer Survival in an Immunocompetent Orthotopic Murine Model.
Yeo D, Huynh N, Beutler JA, Baldwin GS, He H, Nikfarjam M. Yeo D, et al. Among authors: huynh n. J Invest Surg. 2016 Dec;29(6):366-372. doi: 10.3109/08941939.2016.1160167. Epub 2016 Mar 30. J Invest Surg. 2016. PMID: 27027695
Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer.
Huynh N, Shulkes A, Baldwin G, He H. Huynh N, et al. Cancer Biol Ther. 2016 Aug 2;17(8):813-23. doi: 10.1080/15384047.2016.1195045. Epub 2016 Jun 3. Cancer Biol Ther. 2016. PMID: 27260988 Free PMC article.
Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis.
Huynh N, Wang K, Yim M, Dumesny CJ, Sandrin MS, Baldwin GS, Nikfarjam M, He H. Huynh N, et al. BMC Cancer. 2017 Jun 19;17(1):431. doi: 10.1186/s12885-017-3432-0. BMC Cancer. 2017. PMID: 28629331 Free PMC article.
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