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Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle.
Jih KY, Hwang TC. Jih KY, et al. Among authors: hwang tc. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4404-9. doi: 10.1073/pnas.1215982110. Epub 2013 Feb 25. Proc Natl Acad Sci U S A. 2013. PMID: 23440202 Free PMC article.
Direct modulation of secretory chloride channels by arachidonic and other cis unsaturated fatty acids.
Hwang TC, Guggino SE, Guggino WB. Hwang TC, et al. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5706-9. doi: 10.1073/pnas.87.15.5706. Proc Natl Acad Sci U S A. 1990. PMID: 1696009 Free PMC article.
Coupling of CFTR Cl- channel gating to an ATP hydrolysis cycle.
Baukrowitz T, Hwang TC, Nairn AC, Gadsby DC. Baukrowitz T, et al. Among authors: hwang tc. Neuron. 1994 Mar;12(3):473-82. doi: 10.1016/0896-6273(94)90206-2. Neuron. 1994. PMID: 7512348
Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis.
Hwang TC, Nagel G, Nairn AC, Gadsby DC. Hwang TC, et al. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4698-702. doi: 10.1073/pnas.91.11.4698. Proc Natl Acad Sci U S A. 1994. PMID: 7515176 Free PMC article.
Regulation of CFTR channel gating.
Gadsby DC, Hwang TC, Baukrowitz T, Nagel G, Horie M, Nairn AC. Gadsby DC, et al. Among authors: hwang tc. Jpn J Physiol. 1994;44 Suppl 2:S183-92. Jpn J Physiol. 1994. PMID: 7752525
Modulation of CFTR chloride channels by calyculin A and genistein.
Yang IC, Cheng TH, Wang F, Price EM, Hwang TC. Yang IC, et al. Among authors: hwang tc. Am J Physiol. 1997 Jan;272(1 Pt 1):C142-55. doi: 10.1152/ajpcell.1997.272.1.C142. Am J Physiol. 1997. PMID: 9038820
Genistein potentiates wild-type and delta F508-CFTR channel activity.
Hwang TC, Wang F, Yang IC, Reenstra WW. Hwang TC, et al. Am J Physiol. 1997 Sep;273(3 Pt 1):C988-98. doi: 10.1152/ajpcell.1997.273.3.C988. Am J Physiol. 1997. PMID: 9316420
Actions of genistein on cystic fibrosis transmembrane conductance regulator channel gating. Evidence for two binding sites with opposite effects.
Wang F, Zeltwanger S, Yang IC, Nairn AC, Hwang TC. Wang F, et al. Among authors: hwang tc. J Gen Physiol. 1998 Mar;111(3):477-90. doi: 10.1085/jgp.111.3.477. J Gen Physiol. 1998. PMID: 9482713 Free PMC article.
Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms.
Al-Nakkash L, Hwang TC. Al-Nakkash L, et al. Among authors: hwang tc. Pflugers Arch. 1999 Mar;437(4):553-61. doi: 10.1007/s004240050817. Pflugers Arch. 1999. PMID: 10089568
Gating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis. Quantitative analysis of a cyclic gating scheme.
Zeltwanger S, Wang F, Wang GT, Gillis KD, Hwang TC. Zeltwanger S, et al. Among authors: hwang tc. J Gen Physiol. 1999 Apr;113(4):541-54. doi: 10.1085/jgp.113.4.541. J Gen Physiol. 1999. PMID: 10102935 Free PMC article.
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