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Hyaluronan synthesis supports glutamate transporter activity.
Hayashi MK, Nishioka T, Shimizu H, Takahashi K, Kakegawa W, Mikami T, Hirayama Y, Koizumi S, Yoshida S, Yuzaki M, Tammi M, Sekino Y, Kaibuchi K, Shigemoto-Mogami Y, Yasui M, Sato K. Hayashi MK, et al. J Neurochem. 2019 Aug;150(3):249-263. doi: 10.1111/jnc.14791. Epub 2019 Jul 9. J Neurochem. 2019. PMID: 31188471 Free article.
Hyaluronan synthesized by HAS supports the activity of glial glutamate transporter 1 (GLT1). ...Our findings reveal that hyaluronan helps to turn off excitatory signals by supporting glutamate clearance. Cover Image for this …
Hyaluronan synthesized by HAS supports the activity of glial glutamate transporter 1 (GLT1). ...Our findi …
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth.
Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, Saya H. Ishimoto T, et al. Cancer Cell. 2011 Mar 8;19(3):387-400. doi: 10.1016/j.ccr.2011.01.038. Cancer Cell. 2011. PMID: 21397861 Free article.
Here, we show that a CD44 variant (CD44v) interacts with xCT, a glutamate-cystine transporter, and controls the intracellular level of reduced glutathione (GSH). ...It also induced activation of p38(MAPK), a downstream target of ROS, and expression of the gen …
Here, we show that a CD44 variant (CD44v) interacts with xCT, a glutamate-cystine transporter, and controls the intracellular …
TSG-6-Mediated Extracellular Matrix Modifications Regulate Hypoxic-Ischemic Brain Injury.
Srivastava T, Nguyen H, Haden G, Diba P, Sowa S, LaNguyen N, Reed-Dustin W, Zhu W, Gong X, Harris EN, Baltan S, Back SA. Srivastava T, et al. J Neurosci. 2024 May 22;44(21):e2215232024. doi: 10.1523/JNEUROSCI.2215-23.2024. J Neurosci. 2024. PMID: 38569926 Free PMC article.
Hypoxic-ischemic (H-I) injury disrupts cellular homeostasis by activating inflammation and attenuating regeneration and repair pathways. In the brain, the main component of the ECM is the glycosaminoglycan hyaluronic acid (HA), but whether HA modifications of …
Hypoxic-ischemic (H-I) injury disrupts cellular homeostasis by activating inflammation and attenuating regeneration and repair pathwa …
CD44 signaling in Müller cells impacts photoreceptor function and survival in healthy and diseased retinas.
Ayten M, Straub T, Kaplan L, Hauck SM, Grosche A, Koch SF. Ayten M, et al. J Neuroinflammation. 2024 Aug 2;21(1):190. doi: 10.1186/s12974-024-03175-8. J Neuroinflammation. 2024. PMID: 39095775 Free PMC article.
The initial mutation-driven photoreceptor degeneration leads to chronic inflammation, characterized by Muller cell activation and upregulation of CD44. CD44 is a cell surface transmembrane glycoprotein and the primary receptor for hyaluronic acid. ...To under …
The initial mutation-driven photoreceptor degeneration leads to chronic inflammation, characterized by Muller cell activation and upr …