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Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels.
Elies J, Scragg JL, Huang S, Dallas ML, Huang D, MacDougall D, Boyle JP, Gamper N, Peers C. Elies J, et al. FASEB J. 2014 Dec;28(12):5376-87. doi: 10.1096/fj.14-257113. Epub 2014 Sep 2. FASEB J. 2014. PMID: 25183670
Inhibition of native T-type channels in 3 cell lines correlated with expression of Cav3.2 and not Cav3.1 channels. Notably, H2S also inhibited native T-type (primarily Cav3.2) channels in s
Inhibition of native T-type channels in 3 cell lines correlated with expression of Cav3.2 and not
Inhibition of T-type Ca2+ Channels by Hydrogen Sulfide.
Elies J, Scragg JL, Dallas ML, Huang D, Huang S, Boyle JP, Gamper N, Peers C. Elies J, et al. Adv Exp Med Biol. 2015;860:353-60. doi: 10.1007/978-3-319-18440-1_40. Adv Exp Med Biol. 2015. PMID: 26303500
Using patch-clamp electrophysiology, we demonstrate that the H(2)S donor, NaHS, selectively inhibits Cav3.2 T-type Ca(2+) channels heterologously expressed in HEK293 cells, whilst Cav3.1 and Cav3.3 channels were unaffected. ...Chel …
Using patch-clamp electrophysiology, we demonstrate that the H(2)S donor, NaHS, selectively inhibits Cav3.2 T- …
Regulation of the T-type Ca(2+) channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H2 S in nociception.
Elies J, Scragg JL, Boyle JP, Gamper N, Peers C. Elies J, et al. J Physiol. 2016 Aug 1;594(15):4119-29. doi: 10.1113/JP270963. Epub 2016 Feb 25. J Physiol. 2016. PMID: 26804000 Free PMC article. Review.
Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monoxide and, as described more recently, hydrogen sulfide. Indeed, many of the biological actions of these gases can be accounted …
Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monox …
Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis.
Terada Y, Fujimura M, Nishimura S, Tsubota M, Sekiguchi F, Kawabata A. Terada Y, et al. J Neurosci Res. 2015 Feb;93(2):361-9. doi: 10.1002/jnr.23490. Epub 2014 Sep 30. J Neurosci Res. 2015. PMID: 25267397
Hydrogen sulfide (H(2)S), formed by multiple enzymes, including cystathionine-gamma-lyase (CSE), targets Ca(v)3.2 T-type Ca(2+) channels (T channels) and transient receptor potential ankyrin-1 (TRPA1), facilitating somatic pain. ...In the
Hydrogen sulfide (H(2)S), formed by multiple enzymes, including cystathionine-gamma-lyase (CSE), targets Ca(v)3.2 T-
Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells.
Sekiguchi F, Miyamoto Y, Kanaoka D, Ide H, Yoshida S, Ohkubo T, Kawabata A. Sekiguchi F, et al. Biochem Biophys Res Commun. 2014 Feb 28;445(1):225-9. doi: 10.1016/j.bbrc.2014.01.185. Epub 2014 Feb 6. Biochem Biophys Res Commun. 2014. PMID: 24508802
We have shown that an H2S donor, NaHS, causes hyperalgesia in rodents, an effect inhibited by knockdown of Cav3.2 T-type Ca(2+) channels (T-channels), and that NaHS facilitates T-channel-dependent currents (T-currents) in NG …
We have shown that an H2S donor, NaHS, causes hyperalgesia in rodents, an effect inhibited by knockdown of Cav3.2 T
Sulfide and polysulfide as pronociceptive mediators: Focus on Ca(v)3.2 function enhancement and TRPA1 activation.
Sekiguchi F, Tsubota M, Kawabata A. Sekiguchi F, et al. J Pharmacol Sci. 2024 Jul;155(3):113-120. doi: 10.1016/j.jphs.2024.04.007. Epub 2024 May 3. J Pharmacol Sci. 2024. PMID: 38797535 Free article. Review.
Sulfides over a wide micromolar concentration range enhance the activity of Ca(v)3.2 T-type Ca(2+) channels by eliminating Zn(2+) bound to the channels, thereby promoting somatic and visceral pain. Ca(v)3.2 is under inhibition by Zn(2+) in physi …
Sulfides over a wide micromolar concentration range enhance the activity of Ca(v)3.2 T-type Ca(2+) channels by eliminat …
[Role of hydrogen sulfide, a gasotransmitter, in colonic pain and inflammation].
Tsubota M, Kawabata A. Tsubota M, et al. Yakugaku Zasshi. 2014;134(12):1245-52. doi: 10.1248/yakushi.14-00209-2. Yakugaku Zasshi. 2014. PMID: 25452234 Free article. Review. Japanese.
We previously demonstrated that H2S activates Cav3.2 T-type Ca(2+) channels expressed on sensory neurons, leading to hyperalgesia and facilitation of inflammation. ...The pronociceptive effect of NaHS was abolished by inhibitors or knockdown of …
We previously demonstrated that H2S activates Cav3.2 T-type Ca(2+) channels expressed on sensory neurons, …
Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels.
Maeda Y, Aoki Y, Sekiguchi F, Matsunami M, Takahashi T, Nishikawa H, Kawabata A. Maeda Y, et al. Pain. 2009 Mar;142(1-2):127-32. doi: 10.1016/j.pain.2008.12.021. Epub 2009 Jan 23. Pain. 2009. PMID: 19167819
Hydrogen sulfide (H2S), a gasotransmitter, facilitates membrane currents through T-type Ca2+ channels, and intraplantar (i.pl.) administration of NaHS, a donor of H2S, causes prompt hyperalgesia in rats. ...NaHS was abolished by co-admini
Hydrogen sulfide (H2S), a gasotransmitter, facilitates membrane currents through T-type Ca2+ channels
H2S and Pain: A Novel Aspect for Processing of Somatic, Visceral and Neuropathic Pain Signals.
Terada Y, Kawabata A. Terada Y, et al. Handb Exp Pharmacol. 2015;230:217-30. doi: 10.1007/978-3-319-18144-8_11. Handb Exp Pharmacol. 2015. PMID: 26162837 Review.
Hydrogen sulfide (H2S) formed by multiple enzymes including cystathionine-gamma-lyase (CSE) targets Cav3.2 T-type Ca2+ channels (T-channels) and transient receptor potential ankyrin-1 (TRPA1). ...Electrophysiological
Hydrogen sulfide (H2S) formed by multiple enzymes including cystathionine-gamma-lyase (CSE) targets Cav3.2 T
Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels.
Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A, Wood ME, Lacinova L, Ondrias K, Whiteman M. Tomasova L, et al. Nitric Oxide. 2015 Apr 30;46:131-44. doi: 10.1016/j.niox.2014.12.012. Epub 2014 Dec 30. Nitric Oxide. 2015. PMID: 25555533
The involvement of membrane channels T-type Ca(2+) channels CaV3.1, CaV3.2 and CaV3.3 as well as Ca(2+) ryanodine (RyR2) and Cl(-) single channels derived from rat heart sarcoplasmic reticulum were also investigated. ...In electrop …
The involvement of membrane channels T-type Ca(2+) channels CaV3.1, CaV3.2 and CaV3.3 as well as C …
13 results