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Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease.
Krauss-Etschmann S, Bush A, Bellusci S, Brusselle GG, Dahlén SE, Dehmel S, Eickelberg O, Gibson G, Hylkema MN, Knaus P, Königshoff M, Lloyd CM, Macciarini P, Mailleux A, Marsland BJ, Postma DS, Roberts G, Samakovlis C, Stocks J, Vandesompele J, Wjst M, Holloway J. Krauss-Etschmann S, et al. Among authors: hylkema mn. Thorax. 2013 Apr;68(4):380-4. doi: 10.1136/thoraxjnl-2012-201902. Epub 2012 Jul 10. Thorax. 2013. PMID: 22781122 Review.
Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring.
Meyer KF, Krauss-Etschmann S, Kooistra W, Reinders-Luinge M, Timens W, Kobzik L, Plösch T, Hylkema MN. Meyer KF, et al. Among authors: hylkema mn. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L542-L555. doi: 10.1152/ajplung.00271.2016. Epub 2017 Jan 27. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 28130259 Free article.
Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner.
Dehmel S, Nathan P, Bartel S, El-Merhie N, Scherb H, Milger K, John-Schuster G, Yildirim AO, Hylkema M, Irmler M, Beckers J, Schaub B, Eickelberg O, Krauss-Etschmann S. Dehmel S, et al. Sci Rep. 2018 May 15;8(1):7547. doi: 10.1038/s41598-018-25762-5. Sci Rep. 2018. PMID: 29765129 Free PMC article.
Prenatal smoke effect on mouse offspring Igf1 promoter methylation from fetal stage to adulthood is organ and sex specific.
Zeng Z, Meyer KF, Lkhagvadorj K, Kooistra W, Reinders-Luinge M, Xu X, Huo X, Song J, Plösch T, Hylkema MN. Zeng Z, et al. Among authors: hylkema mn. Am J Physiol Lung Cell Mol Physiol. 2020 Mar 1;318(3):L549-L561. doi: 10.1152/ajplung.00293.2019. Epub 2020 Jan 8. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31913647 Free article.
Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring.
Lkhagvadorj K, Meyer KF, Verweij LP, Kooistra W, Reinders-Luinge M, Dijkhuizen HW, de Graaf IAM, Plösch T, Hylkema MN. Lkhagvadorj K, et al. Among authors: hylkema mn. Epigenetics. 2020 Dec;15(12):1370-1385. doi: 10.1080/15592294.2020.1782655. Epub 2020 Jun 23. Epigenetics. 2020. PMID: 32573327 Free PMC article.
110 results